Search Results - "Ayewoh, Ebehiremen"
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S-acylation status of bile acid transporter hASBT regulates its function, metabolic stability, membrane expression, and phosphorylation state
Published in Biochimica et biophysica acta. Biomembranes (01-02-2021)“…The human apical sodium-dependent bile acid transporter (hASBT, SLC10A2) is the rate-limiting step of intestinal bile acid absorption in the enterohepatic…”
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Tyrosine Phosphorylation Regulates Plasma Membrane Expression and Stability of the Human Bile Acid Transporter ASBT (SLC10A2)
Published in Molecular pharmaceutics (05-08-2019)“…The human apical sodium-dependent bile acid transporter (hASBT; SLC10A2) is responsible for the reclamation of bile acids from the intestinal lumen, providing…”
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Sialic Acid Mediated Endothelial and Hepatic Uptake: A Mechanism based Mathematic Model Elucidating the Complex Pharmacokinetics and Pharmacodynamics of Efmarodocokin Alfa, a Variably Glycosylated Fusion Protein
Published in Journal of pharmaceutical sciences (01-07-2024)“…Sialic acid (SA) is crucial for protecting glycoproteins from clearance. Efmarodocokin alfa (IL-22Fc), a fusion protein agonist that links IL-22 to the…”
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Exploring How Antibody Format Drives Clearance from the Brain
Published in Molecular pharmaceutics (02-09-2024)“…Monoclonal antibodies (mAbs) have high binding specificity and affinity, making them attractive for treating brain diseases. However, their effectiveness is…”
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Molecular Mechanisms of Intestinal Bile Acid Transport and Immunomodulatory Potential of Bile Acids
Published 01-01-2021“…Bile acids are catabolic products of cholesterol that play an important role in the digestion of dietary facts, lipid soluble vitamins, and drugs, as well as a…”
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Dissertation