Search Results - "Ayer, D. E"

β-Catenin–Histone Deacetylase Interactions Regulate the Transition of LEF1 from a Transcriptional Repressor to an Activator by Billin, Andrew N., Thirlwell, Hilary, Ayer, Donald E.

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A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation by AYER, D. E, EISENMAN, R. N

“…Mad is a basic-helix-loop-helix-zipper protein that heterodimerizes with Max in vitro. Mad:Max heterodimers recognize the same E-box-related DNA-binding sites…”
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Pf1, a Novel PHD Zinc Finger Protein That Links the TLE Corepressor to the mSin3A-Histone Deacetylase Complex by Yochum, Gregory S., Ayer, Donald E.

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MondoA, a Novel Basic Helix-Loop-Helix–Leucine Zipper Transcriptional Activator That Constitutes a Positive Branch of a Max-Like Network by Billin, Andrew N., Eilers, Alanna L., Coulter, Kathryn L., Logan, Jennifer S., Ayer, Donald E.

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Myc‐Max heterodimers activate a DEAD box gene and interact with multiple E box‐related sites in vivo by Grandori, C., Mac, J., Siëbelt, F., Ayer, D. E., Eisenman, R. N.

“…The c‐Myc protein is involved in cell proliferation, differentiation and apoptosis though heterodimerization with Max to form a transcriptionally active…”
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Coordination of nutrient availability and utilization by MAX- and MLX-centered transcription networks by O'Shea, John M, Ayer, Donald E

“…Cell growth and division require the biosynthesis of macromolecule components and cofactors (e.g., nucleotides, lipids, amino acids, and nicotinamide adenine…”
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Mad3 and Mad4: novel Max‐interacting transcriptional repressors that suppress c‐myc dependent transformation and are expressed during neural and epidermal differentiation by Hurlin, P. J., Quéva, C., Koskinen, P. J., Steingrímsson, E., Ayer, D. E., Copeland, N. G., Jenkins, N. A., Eisenman, R. N.

“…The basic helix‐loop‐helix‐leucine zipper (bHLHZip) protein Max associates with members of the Myc family, as well as with the related proteins Mad (Mad1) and…”
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Mad proteins contain a dominant transcription repression domain by Ayer, Donald E., Laherty, Carol D., Lawrence, Quentin A., Armstrong, Allison P., Eisenman, Robert N.

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Regulation of Myc and Mad during epidermal differentiation and HPV-associated tumorigenesis by Hurlin, P J, Foley, K P, Ayer, D E, Eisenman, R N, Hanahan, D, Arbeit, J M

“…c-Myc and Mad each form heterodimers with Max that bind the same E-box related DNA sequences. Whereas Myc:Max complexes activate transcription and promote cell…”
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Transcriptional and Translational Downregulation of Thioredoxin Interacting Protein Is Required for Metabolic Reprogramming during G1 by Elgort, M. G., O'Shea, J. M., Jiang, Y., Ayer, D. E.

“…Growth factor signaling drives increased glucose uptake and glycolysis—the Warburg effect—that supports macromolecular synthesis necessary for cell growth and…”
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Inhibition of cell proliferation by the Mad1 transcriptional repressor by Roussel, Martine F., Ashmun, Richard A., Sherr, Charles J., Eisenman, Robert N., Ayer, Donald E.

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The Mlx network: evidence for a parallel Max-like transcriptional network that regulates energy metabolism by Billin, A N, Ayer, D E

“…Recent experiments suggest the existence of a transcriptional network that functions in parallel to the canonical Myc/Max/Mad transcriptional network. Unlike…”
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Histone deacetylases: transcriptional repression with SINers and NuRDs by Ayer, Donald E

“…The DNA in eukaryotic cells is packaged into chromatin, which functions as a boundary to the transcriptional activation process. The nucleosome is the basic…”
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Simian virus 40 major late promoter: a novel tripartite structure that includes intragenic sequences by AYER, D. E, DYNAN, W. S

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SIN3-dependent transcriptional repression by interaction with the Mad1 DNA-binding protein by Kasten, Margaret M., Ayer, Donald E., Stillman, David J.

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Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase by Nagy, Laszlo, Kao, Hung-Ying, Chakravarti, Debabrata, Lin, Richard J, Hassig, Christian A, Ayer, Donald E, Schreiber, Stuart L, Evans, Ronald M

“…The transcriptional corepressors SMRT and N-CoR function as silencing mediators for retinoid and thyroid hormone receptors. Here we show that SMRT and N-CoR…”
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Histone Deacetylase Activity Is Required for Full Transcriptional Repression by mSin3A by Hassig, Christian A, Fleischer, Tracey C, Billin, Andrew N, Schreiber, Stuart L, Ayer, Donald E

“…Members of the Mad family of bHLH-Zip proteins heterodimerize with Max to repress transcription in a sequence-specific manner. Transcriptional repression by…”
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Mad-max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3 by Ayer, Donald E, Lawrence, Quentin A, Eisenman, Robert N

“…The bHLH-ZIP protein Mad heterodimerizes with Max as a sequence-specific transcriptional repressor. Mad is rapidly induced upon differentiation, and the…”
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Novel 21-aminosteroids that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma by Jacobsen, E. Jon, McCall, John M, Ayer, Donald E, VanDoornik, Fred J, Palmer, John R, Belonga, Kenneth L, Braughler, J. Mark, Hall, Edward D, Houser, David J

“…A novel class of 21-aminosteroids has been developed. Compounds within this series are potent inhibitors of iron-dependent lipid peroxidation in rat brain…”
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Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity by Ayer, D E, Kretzner, L, Eisenman, R N

“…Myc family proteins appear to function through heterodimerization with the stable, constitutively expressed bHLH-Zip protein, Max. To determine whether Max…”
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