Search Results - "Ayello, Janet"

Targeting CD20+ Aggressive B-cell Non-Hodgkin Lymphoma by Anti-CD20 CAR mRNA-Modified Expanded Natural Killer Cells In Vitro and in NSG Mice by Chu, Yaya, Hochberg, Jessica, Yahr, Ashlin, Ayello, Janet, van de Ven, Carmella, Barth, Matthew, Czuczman, Myron, Cairo, Mitchell S

“…The prognosis is very dismal for patients with relapsed CD20(+) B-cell non-Hodgkin lymphoma (B-NHL). Facilitating the development of alternative novel…”
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Romidepsin alone or in combination with anti-CD20 chimeric antigen receptor expanded natural killer cells targeting Burkitt lymphoma in vitro and in immunodeficient mice by Chu, Yaya, Yahr, Ashlin, Huang, Brian, Ayello, Janet, Barth, Matthew, S. Cairo, Mitchell

“…Facilitating the development of alternative targeted therapeutic strategies is urgently required to improve outcome or circumvent chemotherapy resistance in…”
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A humanized orthotopic mouse model for preclinical evaluation of immunotherapy in Ewing sarcoma by Luo, Wen, Hoang, Hai, Liao, Yanling, Pan, Jian, Ayello, Janet, Cairo, Mitchell S

“…The advent of novel cancer immunotherapy approaches is revolutionizing the treatment for cancer. Current small animal models for most cancers are syngeneic or…”
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Stable to improved cardiac and pulmonary function in children with high-risk sickle cell disease following haploidentical stem cell transplantation by Friedman, Deborah, Dozor, Allen J., Milner, Jordan, D’Souza, Marise, Talano, Julie-An, Moore, Theodore B., Shenoy, Shalini, Shi, Qiuhu, Walters, Mark C., Vichinsky, Elliott, Parsons, Susan K., Braniecki, Suzanne, Moorthy, Chitti R., Ayello, Janet, Flower, Allyson, Morris, Erin, Mahanti, Harshini, Fabricatore, Sandra, Klejmont, Liana, van de Ven, Carmella, Baxter-Lowe, Lee Ann, Cairo, Mitchell S.

“…Children with sickle cell disease (SCD) are at high-risk of progressive, chronic pulmonary and cardiac dysfunction. In this prospective multicenter Phase II…”
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Ruxolitinib significantly enhances in vitro apoptosis in Hodgkin lymphoma and primary mediastinal B-cell lymphoma and survival in a lymphoma xenograft murine model by Lee, Sanghoon, Shah, Tishi, Yin, Changhong, Hochberg, Jessica, Ayello, Janet, Morris, Erin, van de Ven, Carmella, Cairo, Mitchell S

“…Hodgkin lymphoma (HL) and primary mediastinal B-cell lymphoma (PMBL) share similar molecular features by gene expression profiling. Frequent gains of…”
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Combinatorial macrophage induced innate immunotherapy against Ewing sarcoma: Turning "Two Keys" simultaneously by Luo, Wen, Hoang, Hai, Miller, Katherine E, Zhu, Hongwen, Xu, Serena, Mo, Xiaokui, Garfinkle, Elizabeth A R, Costello, Heather, Wijeratne, Saranga, Chemnitz, Wiebke, Gandhi, Ronan, Liao, Yanling, Ayello, Janet, Gardenswartz, Aliza, Rosenblum, Jeremy M, Cassady, Kevin A, Mardis, Elaine R, Lee, Dean A, Cripe, Timothy P, Cairo, Mitchell S

“…Macrophages play important roles in phagocytosing tumor cells. However, tumors escape macrophage phagocytosis in part through the expression of anti-phagocytic…”
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The effects of DLEU1 gene expression in Burkitt lymphoma (BL): potential mechanism of chemoimmunotherapy resistance in BL by Lee, Sanghoon, Luo, Wen, Shah, Tishi, Yin, Changhong, O'Connell, Timmy, Chung, Tae-Hoon, Perkins, Sherrie L, Miles, Rodney R, Ayello, Janet, Morris, Erin, Harrison, Lauren, van de Ven, Carmella, Cairo, Mitchell S

“…Following a multivariant analysis we demonstrated that children and adolescents with Burkitt lymphoma (BL) and a 13q14.3 deletion have a significant decrease…”
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Donor chimerism and immune reconstitution following haploidentical transplantation in sickle cell disease by Chu, Yaya, Talano, Julie-An, Baxter-Lowe, Lee Ann, Verbsky, James W, Morris, Erin, Mahanti, Harshini, Ayello, Janet, Keever-Taylor, Carolyn, Johnson, Bryon, Weinberg, Rona S, Shi, Qiuhu, Moore, Theodore B, Fabricatore, Sandra, Grossman, Brenda, van de Ven, Carmella, Shenoy, Shalini, Cairo, Mitchell S

“…We previously reported the initial results of a phase II multicenter transplant trial using haploidentical parental donors for children and aolescents with…”
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Immunophenotypic, cytotoxic, proteomic and genomic characterization of human cord blood vs. peripheral blood CD56 NK cells by Evan Shereck, Nancy S Day, Aradhana Awasthi, Janet Ayello, Yaya Chu, Catherine McGuinn, Carmella van de Ven, Megan S Lim, Mitchell S Cairo

“…Unrelated cord blood (CB) is an excellent alternative as an allogeneic donor source for stem cell transplantation. CB transplantation is associated with lower…”
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Circumventing resistance within the Ewing sarcoma microenvironment by combinatorial innate immunotherapy by Luo, Wen, Hoang, Hai, Zhu, Hongwen, Miller, Katherine, Mo, Xiaokui, Eguchi, Shiori, Tian, Meijuan, Liao, Yanling, Ayello, Janet, Rosenblum, Jeremy M, Marcondes, Mario, Currier, Mark, Mardis, Elaine, Cripe, Timothy, Lee, Dean, Cairo, Mitchell S

“…BackgroundPediatric patients with recurrent/metastatic Ewing sarcoma (ES) have a dismal 5-year survival. Novel therapeutic approaches are desperately needed…”
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Safety, Pharmacokinetics, and Immunomodulatory Effects of Lenalidomide in Children and Adolescents With Relapsed/Refractory Solid Tumors or Myelodysplastic Syndrome: A Children's Oncology Group Phase I Consortium Report by BERG, Stacey L, CAIRO, Mitchell S, RUSSELL, Heidi, AYELLO, Janet, INGLE, Ashish Mark, LAU, Henry, CHEN, Nianhang, ADAMSON, Peter C, BLANEY, Susan M

“…To determine the maximum-tolerated or recommended phase II dose, dose-limiting toxicities (DLTs), pharmacokinetics (PK), and immunomodulatory effects of…”
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Immunophenotypic, cytotoxic, proteomic and genomic characterization of human cord blood vs. peripheral blood CD56Dim NK cells by Shereck, Evan, Day, Nancy S, Awasthi, Aradhana, Ayello, Janet, Chu, Yaya, McGuinn, Catherine, van de Ven, Carmella, Lim, Megan S, Cairo, Mitchell S

“…Unrelated cord blood (CB) is an excellent alternative as an allogeneic donor source for stem cell transplantation. CB transplantation is associated with lower…”
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Rescue of the Mucocutaneous Manifestations by Human Cord Blood Derived Nonhematopoietic Stem Cells in a Mouse Model of Recessive Dystrophic Epidermolysis Bullosa by Liao, Yanling, Ivanova, Larisa, Zhu, Hongwen, Yahr, Ashlin, Ayello, Janet, van de Ven, Carmella, Rashad, Ahmed, Uitto, Jouni, Christiano, Angela M., Cairo, Mitchell S.

“…Recessive dystrophic epidermolysis bullosa (RDEB) is a severe skin blistering disease caused by mutations in COL7A1‐encoding type VII collagen (C7). Currently,…”
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Differential proteomic analysis of endemic and sporadic Epstein–Barr virus-positive and negative Burkitt lymphoma by El-Mallawany, Nader Kim, Day, Nancy, Ayello, Janet, Van de Ven, Carmella, Conlon, Kevin, Fermin, Damian, Basrur, Venkatesha, Elenitoba-Johnson, Kojo, Lim, Megan, Cairo, Mitchell S

“…Abstract Background Burkitt lymphoma (BL) is the most common non-Hodgkin lymphoma in children worldwide and the most common paediatric malignancy in…”
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Ibrutinib significantly inhibited Bruton's tyrosine kinase (BTK) phosphorylation,in-vitro proliferation and enhanced overall survival in a preclinical Burkitt lymphoma (BL) model by Chu, Yaya, Lee, Sanghoon, Shah, Tishi, Yin, Changhong, Barth, Matthew, Miles, Rodney R., Ayello, Janet, Morris, Erin, Harrison, Lauren, Van de Ven, Carmella, Galardy, Paul, Goldman, Stanton C., Lim, Megan S., Hermiston, Michelle, McAllister-Lucas, Linda M., Giulino-Roth, Lisa, Perkins, Sherrie L., Cairo, Mitchell S.

“…Pediatric and adult patients with recurrent/refractory Burkitt lymphoma (BL) continue to have poor outcomes, emphasizing the need for newer therapeutic agents…”
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Apoptosis of lymphocytes and monocytes infected with influenza virus might be the mechanism of combating virus and causing secondary infection by influenza by Xie, Dongxu, Bai, Hai, Liu, Lihua, Xie, Xiangyu, Ayello, Janet, Ma, Xiaohui, Zhang, Junying

“…Influenza affects most of the world's population annually, often causing a secondary infection, but pathological mechanisms of influenza virus infection remain…”
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Immaturity of IL‐18 gene expression and protein production in cord blood (CB) versus peripheral blood (PB) mononuclear cells and differential effects in natural killer (NK) cell development and function by Satwani, Prakash, Ayello, Janet, Ven, Carmella, O'Neill, Allison F., Simpson, Lynn L., Baxi, Laxmi, Cairo, Mitchell S.

“…Summary We have previously demonstrated dysregulation of IL‐12 and IL‐15 gene and protein expression between activated cord blood (CB) versus peripheral blood…”
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A Phase I Study of 90Yttrium-Ibritumomab-Tiuxetan in Children and Adolescents with Relapsed/Refractory CD20-Positive Non–Hodgkin's Lymphoma: A Children's Oncology Group Study by Cooney-Qualter, Erin, Krailo, Mark, Angiolillo, Anne, Fawwaz, Rashid A, Wiseman, Gregory, Harrison, Lauren, Kohl, Virginia, Adamson, Peter C, Ayello, Janet, vande Ven, Carmella, Perkins, Sherrie L, Cairo, Mitchell S

“…Purpose: The prognosis for children with recurrent CD20 + non–Hodgkin's lymphoma is dismal. A radiolabeled anti-CD20 antibody, 90 yttrium-ibritumomab-tiuxetan…”
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A Phase I Clinical, Pharmacologic, and Biologic Study of Thrombopoietin and Granulocyte Colony-Stimulating Factor in Children Receiving Ifosfamide, Carboplatin, and Etoposide Chemotherapy for Recurrent or Refractory Solid Tumors: A Children's Oncology Group Experience by ANGIOLILLO, Anne L, DAVENPORT, Virginia, BONILLA, Mary Ann, VAN DE VEN, Carmella, AYELLO, Janet, MILITANO, Olga, MILLER, Langdon L, KRAILO, Mark, REAMAN, Gregory, CAIRO, Mitchell S

“…Purpose: Ifosfamide, carboplatin, and etoposide (ICE) are associated with grade III/IV dose-limiting thrombocytopenia. The Children's Oncology Group conducted…”
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Abstract 2381: Blinatumomab enhanced anti-tumor activity against rituximab sensitive and resistant Burkitt Lymphoma (BL) and Primary Mediastinal B-cell Lymphoma (PMBL) by Tiwari, Aradhana Awasthi, Edani, Dina, Ayello, Janet, Cairo, Mitchell S.

“…Abstract Background: Childhood, Adolescent and Young Adult (CAYA) B-NHL represents the third most common malignancies in children under the age of 15yrs…”
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