Potential Protective Effects of Antioxidants against Cyclophosphamide-Induced Nephrotoxicity

Potential Protective Effects of Antioxidants against Cyclophosphamide-Induced Nephrotoxicity

Cyclophosphamide is an alkylating antineoplastic agent, and it is one of the most successful drugs with wide arrays of clinical activity. It has been in use for several types of cancer treatments and as an immunosuppressive agent for the management of autoimmune and immune-mediated diseases. Nowaday...

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Published in:International journal of nephrology Vol. 2022; pp. 5096825 - 12
Main Authors: Ayza, Muluken Altaye, Zewdie, Kaleab Alemayehu, Yigzaw, Elias Fitsum, Ayele, Solomon Gashaw, Tesfaye, Bekalu Amare, Tafere, Gebrehiwot Gebremedhin, Abrha, Muzey Gebreyohannes
Format: Journal Article
Language:English
Published: United States Hindawi 16-04-2022
John Wiley & Sons, Inc
Hindawi Limited
Subjects:
Antioxidants
Apoptosis
Creatinine
Cyclophosphamide
Cytochrome
Drug dosages
Enzymes
Inflammation
Kidneys
Lipid peroxidation
Oxidative stress
Review
Rodents
Scleroderma (Disease)
Systemic scleroderma
Tumor necrosis factor-TNF
Vitamin E
Ethiopia
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Summary:Cyclophosphamide is an alkylating antineoplastic agent, and it is one of the most successful drugs with wide arrays of clinical activity. It has been in use for several types of cancer treatments and as an immunosuppressive agent for the management of autoimmune and immune-mediated diseases. Nowadays, its clinical use is limited due to various toxicities, including nephrotoxicity. Even though the mechanisms are not well understood, cyclophosphamide-induced nephrotoxicity is reported to be mediated through oxidative stress. This review focuses on the potential role of natural and plant-derived antioxidants in preventing cyclophosphamide-induced nephrotoxicity.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Academic Editor: Emmanuel Effa
ISSN:2090-214X
2090-2158
2090-2158
DOI:10.1155/2022/5096825