Search Results - "Ayeb, Mohamed El"

Lipid Biomarkers in Alzheimer's Disease by Zarrouk, Amira, Debbabi, Meryam, Bezine, Maryem, Karym, El Mostafa, Badreddine, Asmaa, Rouaud, Olivier, Moreau, Thibault, Cherkaoui-Malki, Mustapha, El Ayeb, Mohamed, Nasser, Boubker, Hammami, Mohamed, Lizard, Gerard

“…There are now significant evidences that lipid metabolism is affected in numerous neurodegenerative diseases including Alzheimer's disease. These dysfunctions…”
Get more information

First Evidence of Kv3.1b Potassium Channel Subtype Expression during Neuronal Serotonergic 1C11 Cell Line Development by Tabka, Hager, Cheikh, Amani, Maatoug, Sonia, Ayeb, Mohamed El, Bendahhou, Saïd, Benkhalifa, Rym

“…Kv3.1 channel is abundantly expressed in neurons and its dysfunction causes sleep loss, neurodegenerative diseases and depression. Fluoxetine, a serotonin…”
Get full text

bispecific nanobody to provide full protection against lethal scorpion envenoming by Hmila, Issam, Saerens, Dirk, Ben Abderrazek, Rahma, Vincke, Cécile, Abidi, Naima, Benlasfar, Zakaria, Govaert, Jochen, El Ayeb, Mohamed, Bouhaouala-Zahar, Balkiss, Muyldermans, Serge

“…Envenoming following scorpion sting is a common emergency in many parts of the world. Our aim was to ameliorate the current 100-kDa horse plasma antivenom…”
Get full text

Phthalimido–ferrocidiphenol cyclodextrin complexes: Characterization and anticancer activity by Najlaoui, Feten, Pigeon, Pascal, Abdelkafi, Zaineb, Leclerc, Sebastien, Durand, Pierrick, Ayeb, Mohamed El, Marrakchi, Naziha, Rhouma, Ali, Jaouen, Gérard, Gibaud, Stéphane

“…[Display omitted] Several ferrocenyl analogues of tamoxifen have already showed strong antiproliferative activity in experimental glioma models. Nevertheless,…”
Get full text

MVL-PLA2, a snake venom phospholipase A2, inhibits angiogenesis through an increase in microtubule dynamics and disorganization of focal adhesions by Bazaa, Amine, Pasquier, Eddy, Defilles, Céline, Limam, Ines, Kessentini-Zouari, Raoudha, Kallech-Ziri, Olfa, El Battari, Assou, Braguer, Diane, El Ayeb, Mohamed, Marrakchi, Naziha, Luis, José

“…Integrins are essential protagonists of the complex multi-step process of angiogenesis that has now become a major target for the development of anticancer…”
Get full text

Hyalomma dromedarii (Acari: Ixodidae) Salivary Gland Extract Inhibits Angiogenesis and Exhibits In Vitro Antitumor Effects by Bensaoud, Chaima, Abdelkafi-Koubaa, Zaineb, Mabrouk, Hazem Ben, Morjen, Maram, Hmila, Issam, Rhim, Adel, Ayeb, Mohamed El, Marrakchi, Naziha, Bouattour, Ali, M'ghirbi, Youmna

“…Hard ticks (Acari: Ixodidae) are blood-sucking ectoparasites characterized by the extended period of their attachment to their host. To access their bloodmeal,…”
Get full text

Inhibition of human Kv3.1 current expressed in Xenopus oocytes by the toxic venom fraction of Androctonus australis hector by Cheikh, Amani, Benkhalifa, Rym, Landoulsi, Zied, Chatti, Imen, Ayeb, Mohamed El

“…AahG50 , the toxic fraction of Androctonus australis hector venom, was studied on human Kv3.1 channels activation, stably expressed in Xenopus oocytes using…”
Get full text

Lebestatin, a disintegrin from Macrovipera venom, inhibits integrin-mediated cell adhesion, migration and angiogenesis by OLFA, Kallech-Ziri, JOSE, Luis, JEAN-MARC, Sabatier, MOHAMED, El Ayeb, NAZIHA, Marrakchi, SALMA, Daoud, AMINE, Bazaa, SRAIRI ABID NAJET, NICOLAS, Andreotti, MAXIME, Lehmann, RAOUDHA, Zouari, KAMEL, Mabrouk, JACQUES, Marvaldi

“…Lebestatin, a new member of the lysine-threonine-serine (KTS)-disintegrin family, was purified to homogeneity from Tunisian snake (Macrovipera lebetina) venom…”
Get full text

Disintegrin-like Protein Strategy to Inhibit Aggressive Triple-Negative Breast Cancer by Limam, Inès, Abdelkarim, Mohamed, El Ayeb, Mohamed, Crepin, Michel, Marrakchi, Naziha, Di Benedetto, Mélanie

“…Venoms are a rich source of bioactive compounds, and among them is leberagin-C (Leb-C), a disintegrin-like protein derived from the venom of snakes. Leb-C has…”
Get full text

Lebectin, a novel C-type lectin from Macrovipera lebetina venom, inhibits integrin-mediated adhesion, migration and invasion of human tumour cells by Sarray, Sameh, Berthet, Virginie, Calvete, Juan J, Secchi, Jeannine, Marvaldi, Jacques, Ayeb, Mohamed El, Marrakchi, Naziha, Luis, José

“…The adhesion receptors of the integrin family play an essential role during tumour progression and thus represent interesting potential targets for the…”
Get full text

Neutralizing Dromedary-Derived Nanobodies Against BotI-Like Toxin From the Most Hazardous Scorpion Venom in the Middle East and North Africa Region by Ben Abderrazek, Rahma, Ksouri, Ayoub, Idoudi, Faten, Dhaouadi, Sayda, Hamdi, Emna, Vincke, Cécile, Farah, Azer, Benlasfar, Zakaria, Majdoub, Hafedh, El Ayeb, Mohamed, Muyldermans, Serge, Bouhaouala-Zahar, Balkiss

“…Scorpion envenoming is a severe health problem in many regions causing significant clinical toxic effects and fatalities. In the Middle East/North Africa…”
Get full text

VHH, bivalent domains and chimeric Heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI by Hmila, Issam, Abdallah R, Ben Abderrazek-Ben, Saerens, Dirk, Benlasfar, Zakaria, Conrath, Katja, Ayeb, Mohamed El, Muyldermans, Serge, Bouhaouala-Zahar, Balkiss

“…Many efforts aim at solving the serious problems encountered with immunotherapy against scorpion envenoming. The most attractive approach consists in…”
Get full text

Biochemical and monolayer characterization of Tunisian snake venom phospholipases by Baîram, Douja, Aissa, Imen, Louati, Hanen, Othman, Houcemeddine, Abdelkafi-Koubaa, Zaineb, Krayem, Najeh, El Ayeb, Mohamed, Srairi-Abid, Najet, Marrakchi, Naziha, Gargouri, Youssef

“…The present study investigated the kinetic and interfacial properties of two secreted phospholipases isolated from Tunisian vipers’venoms: Cerastes cerastes…”
Get full text

Antitumoral Potential of Tunisian Snake Venoms Secreted Phospholipases A2 by Luis, Jose, El Ayeb, Mohamed, Bazaa, Amine, Srairi-Abid, Najet, Zouari-Kessentini, Raoudha, Marrakchi, Naziha

“…Phospholipases type A2 (PLA2s) are the most abundant proteins found in Viperidae snake venom. They are quite fascinating from both a biological and structural…”
Get full text

Antitumoral potential of Tunisian snake venoms secreted phospholipases [A.sub.2] by Zouari-Kessentini, Raoudha, Srairi-Abid, Najet, Bazaa, Amine, Ayeb, Mohamed El, Luis, Jose, Marrakchi, Naziha

Get full text

Identification of potent nanobodies to neutralize the most poisonous polypeptide from scorpion venom by Abderrazek, Rahma Ben, Hmila, Issam, Vincke, Cécile, Benlasfar, Zakaria, Pellis, Mireille, Dabbek, Hafedh, Saerens, Dirk, El Ayeb, Mohamed, Muyldermans, Serge, Bouhaouala-Zahar, Balkiss

“…Scorpion venom, containing highly toxic, small polypeptides that diffuse rapidly within the patient, causes serious medical problems. Nanobodies, single-domain…”
Get more information

Immunized camel sera and derived immunoglobulin subclasses neutralizing Androctonus australis hector scorpion toxins by Meddeb-Mouelhi, Fatma, Bouhaouala-Zahar, Balkiss, Benlasfar, Zakaria, Hammadi, Mohamed, Mejri, Thouraya, Moslah, Mekki, Karoui, Habib, Khorchani, Touhami, Ayeb, Mohamed El

“…Scorpion envenoming is a real health problem. The only specific treatment is immunotherapy with antibodies from immunized horses. The severity of scorpion…”
Get full text

Dromedary immune response and specific Kv2.1 antibody generation using a specific immunization approach by Hassiki, Rym, Labro, Alain J., Benlasfar, Zakaria, Vincke, Cécile, Somia, Mahmoud, El Ayeb, Mohamed, Muyldermans, Serge, Snyders, Dirk J., Bouhaouala-Zahar, Balkiss

“…Voltage-gated potassium (Kv) channels form cells repolarizing power and are commonly expressed in excitable cells. In non-excitable cells, Kv channels such as…”
Get full text

Lebetin Peptides, A New Class of Potent Platelet Aggregation Inhibitors: Chemical Synthesis, Biological Activity and NMR Spectroscopic Study by Mosbah, Amor, Marrakchi, Naziha, Mansuelle, Pascal, Kouidhi, Soumaya, Giralt, Ernest, El Ayeb, Mohamed, Herbette, Gaëtan, Cherif, Ameur, Gigmes, Didier, Darbon, Hervé, Mabrouk, Kamel

“…Platelets have a well-established role in atherosclerosis and related diseases. Lebetins from the venom of Vipera lebetina , lacking the RGD sequence, emerged…”
Get full text

Hemicalcin, a new toxin from the Iranian scorpion Hemiscorpius lepturus which is active on ryanodine-sensitive Ca2+ channels by Shahbazzadeh, Delavar, Srairi-Abid, Najet, Feng, Wei, Ram, Narendra, Borchani, Lamia, Ronjat, Michel, Akbari, Abolfazl, Pessah, Isaac N, De Waard, Michel, El Ayeb, Mohamed

“…In the present work, we purified and characterized a novel toxin named hemicalcin from the venom of the Iranian chactoid scorpion Hemiscorpius lepturus where…”
Get full text