Search Results - "Aye, Pyone P."

Enhanced IL-17 Producing and Maintained Cytolytic Effector Functions of Gut Mucosal CD161 + CD8 + T Cells in SIV-Infected Rhesus Macaques by Thirugnanam, Siva, Walker, Edith M, Schiro, Faith, Aye, Pyone P, Rappaport, Jay, Rout, Namita

“…Previous studies have indicated that the loss of CD161-expressing CD4 Th17 cells is linked to the progression of chronic HIV. These cells are significantly…”
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Dietary Gluten-Induced Gut Dysbiosis Is Accompanied by Selective Upregulation of microRNAs with Intestinal Tight Junction and Bacteria-Binding Motifs in Rhesus Macaque Model of Celiac Disease by Mohan, Mahesh, Chow, Cheryl-Emiliane T, Ryan, Caitlin N, Chan, Luisa S, Dufour, Jason, Aye, Pyone P, Blanchard, James, Moehs, Charles P, Sestak, Karol

“…The composition of the gut microbiome reflects the overall health status of the host. In this study, stool samples representing the gut microbiomes from 6…”
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The Impact of SIV-Induced Immunodeficiency on SARS-CoV-2 Disease, Viral Dynamics, and Antiviral Immune Response in a Nonhuman Primate Model of Coinfection by Melton, Alexandra, Rowe, Lori A, Penney, Toni, Krzykwa, Clara, Goff, Kelly, Scheuermann, Sarah E, Melton, Hunter J, Williams, Kelsey, Golden, Nadia, Green, Kristyn Moore, Smith, Brandon, Russell-Lodrigue, Kasi, Dufour, Jason P, Doyle-Meyers, Lara A, Schiro, Faith, Aye, Pyone P, Lifson, Jeffery D, Beddingfield, Brandon J, Blair, Robert V, Bohm, Rudolf P, Kolls, Jay K, Rappaport, Jay, Hoxie, James A, Maness, Nicholas J

“…The effects of immunodeficiency associated with chronic HIV infection on COVID-19 disease and viral persistence have not been directly addressed in a…”
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Focused examination of the intestinal epithelium reveals transcriptional signatures consistent with disturbances in enterocyte maturation and differentiation during the course of SIV infection by Mohan, Mahesh, Kaushal, Deepak, Aye, Pyone P, Alvarez, Xavier, Veazey, Ronald S, Lackner, Andrew A

“…The Gastrointestinal (GI) tract plays a pivotal role in AIDS pathogenesis as it is the primary site for viral transmission, replication and CD4(+) T cell…”
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Loss of a Tyrosine-Dependent Trafficking Motif in the Simian Immunodeficiency Virus Envelope Cytoplasmic Tail Spares Mucosal CD4 Cells but Does Not Prevent Disease Progression by Breed, Matthew W, Jordan, Andrea P O, Aye, Pyone P, Lichtveld, Cornelis F, Midkiff, Cecily C, Schiro, Faith R, Haggarty, Beth S, Sugimoto, Chie, Alvarez, Xavier, Sandler, Netanya G, Douek, Daniel C, Kuroda, Marcelo J, Pahar, Bapi, Piatak, Jr, Michael, Lifson, Jeffrey D, Keele, Brandon F, Hoxie, James A, Lackner, Andrew A

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Focused examination of the intestinal lamina propria yields greater molecular insight into mechanisms underlying SIV induced immune dysfunction by Mohan, Mahesh, Kaushal, Deepak, Aye, Pyone P, Alvarez, Xavier, Veazey, Ronald S, Lackner, Andrew A

“…The Gastrointestinal (GI) tract is critical to AIDS pathogenesis as it is the primary site for viral transmission and a major site of viral replication and…”
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Supplementation of Reduced Gluten Barley Diet with Oral Prolyl Endopeptidase Effectively Abrogates Enteropathy-Associated Changes in Gluten-Sensitive Macaques by Sestak, Karol, Thwin, Hazel, Dufour, Jason, Liu, David X, Alvarez, Xavier, Laine, David, Clarke, Adam, Doyle, Anthony, Aye, Pyone P, Blanchard, James, Moehs, Charles P

“…Celiac disease (CD) is an autoimmune disorder that affects approximately three million people in the United States. Furthermore, non-celiac gluten sensitivity…”
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Improved xenobiotic metabolism and reduced susceptibility to cancer in gluten-sensitive macaques upon introduction of a gluten-free diet by Sestak, Karol, Conroy, Lauren, Aye, Pyone P, Mehra, Smriti, Doxiadis, Gaby G, Kaushal, Deepak

“…A non-human primate (NHP) model of gluten sensitivity was employed to study the gene perturbations associated with dietary gluten changes in small intestinal…”
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A Single Amino Acid Mutation in the Envelope Cytoplasmic Tail Restores the Ability of an Attenuated Simian Immunodeficiency Virus Mutant To Deplete Mucosal CD4+ T Cells by Breed, Matthew W, Jordan, Andrea P O, Aye, Pyone P, Sugimoto, Chie, Alvarez, Xavier, Kuroda, Marcelo J, Pahar, Bapi, Keele, Brandon F, Hoxie, James A, Lackner, Andrew A

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The effects of reduced gluten barley diet on humoral and cell-mediated systemic immune responses of gluten-sensitive rhesus macaques by Sestak, Karol, Thwin, Hazel, Dufour, Jason, Aye, Pyone P, Liu, David X, Moehs, Charles P

“…Celiac disease (CD) affects approximately 1% of the general population while an estimated additional 6% suffers from a recently characterized, rapidly…”
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Long-primed germinal centres with enduring affinity maturation and clonal migration by Lee, Jeong Hyun, Sutton, Henry J., Cottrell, Christopher A., Phung, Ivy, Ozorowski, Gabriel, Sewall, Leigh M., Nedellec, Rebecca, Nakao, Catherine, Silva, Murillo, Richey, Sara T., Torres, Jonathan L., Lee, Wen-Hsin, Georgeson, Erik, Kubitz, Michael, Hodges, Sam, Mullen, Tina-Marie, Adachi, Yumiko, Cirelli, Kimberly M., Kaur, Amitinder, Allers, Carolina, Fahlberg, Marissa, Grasperge, Brooke F., Dufour, Jason P., Schiro, Faith, Aye, Pyone P., Kalyuzhniy, Oleksandr, Liguori, Alessia, Carnathan, Diane G., Silvestri, Guido, Shen, Xiaoying, Montefiori, David C., Veazey, Ronald S., Ward, Andrew B., Hangartner, Lars, Burton, Dennis R., Irvine, Darrell J., Schief, William R., Crotty, Shane

“…Germinal centres are the engines of antibody evolution. Here, using human immunodeficiency virus (HIV) Env protein immunogen priming in rhesus monkeys followed…”
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Development of a Rotavirus-Shedding Model in Rhesus Macaques, Using a Homologous Wild-Type Rotavirus of a New P Genotype by MCNEAL, Monica M, SESTAK, Karol, CHOI, Anthony H.-C, BASU, Mitali, COLE, Michael J, AYE, Pyone P, BOHM, Rudolf P, WARD, Richard L

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Infectious Agent and Immune Response Characteristics of Chronic Enterocolitis in Captive Rhesus Macaques by SESTAK, Karol, MERRITT, Christopher K, AYE, Pyone P, ALEXA, Pavel, WARD, Richard L, LACKNER, Andrew A, BORDA, Juan, SAYLOR, Elizabeth, SCHWAMBERGER, Shelle R, COGSWELL, Frank, DIDIER, Elizabeth S, DIDIER, Peter J, PLAUCHE, Gail, BOHM, Rudolf P

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Persistent Simian Immunodeficiency Virus Infection Drives Differentiation, Aberrant Accumulation, and Latent Infection of Germinal Center Follicular T Helper Cells by Xu, Huanbin, Wang, Xiaolei, Malam, Naomi, Aye, Pyone P, Alvarez, Xavier, Lackner, Andrew A, Veazey, Ronald S

“…CD4(+) follicular T helper (Tfh) cells play a prominent role in humoral immune responses, but the mechanisms of their accumulation and infection in AIDS remain…”
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Zika virus infection during pregnancy protects against secondary infection in the absence of CD8+ cells by Schouest, Blake, Beddingfield, Brandon J., Gilbert, Margaret H., Bohm, Rudolf P., Schiro, Faith, Aye, Pyone P., Panganiban, Antonito T., Magnani, Diogo M., Maness, Nicholas J.

“…While T cell immunity is an important component of the immune response to Zika virus (ZIKV) infection generally, the efficacy of these responses during…”
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SIV antigen immunization induces transient antigen-specific T cell responses and selectively activates viral replication in draining lymph nodes in retroviral suppressed rhesus macaques by Hu, Haitao, Gama, Lucio, Aye, Pyone P, Clements, Janice E, Barry, Peter A, Lackner, Andrew A, Weissman, Drew

“…HIV infection causes a qualitative and quantitative loss of CD4+ T cell immunity. The institution of anti-retroviral therapy (ART) restores CD4+ T cell…”
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Co-immunization of DNA and Protein in the Same Anatomical Sites Induces Superior Protective Immune Responses against SHIV Challenge by Felber, Barbara K., Lu, Zhongyan, Hu, Xintao, Valentin, Antonio, Rosati, Margherita, Remmel, Christopher A.L., Weiner, Joshua A., Carpenter, Margaret C., Faircloth, Katelyn, Stanfield-Oakley, Sherry, Williams, Wilton B., Shen, Xiaoying, Tomaras, Georgia D., LaBranche, Celia C., Montefiori, David, Trinh, Hung V., Rao, Mangala, Alam, Munir S., Vandergrift, Nathan A., Saunders, Kevin O., Wang, Yunfei, Rountree, Wes, Das, Jishnu, Alter, Galit, Reed, Steven G., Aye, Pyone P., Schiro, Faith, Pahar, Bapi, Dufour, Jason P., Veazey, Ronald S., Marx, Preston A., Venzon, David J., Shaw, George M., Ferrari, Guido, Ackerman, Margaret E., Haynes, Barton F., Pavlakis, George N.

“…We compare immunogenicity and protective efficacy of an HIV vaccine comprised of env and gag DNA and Env (Envelope) proteins by co-administration of the…”
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Author Correction: Long-primed germinal centres with enduring affinity maturation and clonal migration by Lee, Jeong Hyun, Sutton, Henry J., Cottrell, Christopher A., Phung, Ivy, Ozorowski, Gabriel, Sewall, Leigh M., Nedellec, Rebecca, Nakao, Catherine, Silva, Murillo, Richey, Sara T., Torres, Jonathan L., Lee, Wen-Hsin, Georgeson, Erik, Kubitz, Michael, Hodges, Sam, Mullen, Tina-Marie, Adachi, Yumiko, Cirelli, Kimberly M., Kaur, Amitinder, Allers, Carolina, Fahlberg, Marissa, Grasperge, Brooke F., Dufour, Jason P., Schiro, Faith, Aye, Pyone P., Kalyuzhniy, Oleksandr, Liguori, Alessia, Carnathan, Diane G., Silvestri, Guido, Shen, Xiaoying, Montefiori, David C., Veazey, Ronald S., Ward, Andrew B., Hangartner, Lars, Burton, Dennis R., Irvine, Darrell J., Schief, William R., Crotty, Shane

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The pigtail macaque (Macaca nemestrina) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of disease by Melton, Alexandra, Doyle-Meyers, Lara A, Blair, Robert V, Midkiff, Cecily, Melton, Hunter J, Russell-Lodrigue, Kasi, Aye, Pyone P, Schiro, Faith, Fahlberg, Marissa, Szeltner, Dawn, Spencer, Skye, Beddingfield, Brandon J, Goff, Kelly, Golden, Nadia, Penney, Toni, Picou, Breanna, Hensley, Krystle, Chandler, Kristin E, Plante, Jessica A, Plante, Kenneth S, Weaver, Scott C, Roy, Chad J, Hoxie, James A, Gao, Hongmei, Montefiori, David C, Mankowski, Joseph L, Bohm, Rudolf P, Rappaport, Jay, Maness, Nicholas J

“…The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 disease, has killed over five million people worldwide as of December 2021 with infections…”
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Postnatal Zika virus infection of nonhuman primate infants born to mothers infected with homologous Brazilian Zika virus by Maness, Nicholas J., Schouest, Blake, Singapuri, Anil, Dennis, Maria, Gilbert, Margaret H., Bohm, Rudolf P., Schiro, Faith, Aye, Pyone P., Baker, Kate, Van Rompay, Koen K. A., Lackner, Andrew A., Bonaldo, Myrna C., Blair, Robert V., Permar, Sallie R., Coffey, Lark L., Panganiban, Antonito T., Magnani, Diogo

“…Recent data in a nonhuman primate model showed that infants postnatally infected with Zika virus (ZIKV) were acutely susceptible to high viremia and…”
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