Search Results - "Aydintug, M Kemal"

γδ T cells affect IL-4 production and B-cell tolerance by Huang, Yafei, Heiser, Ryan A., Detanico, Thiago O., Getahun, Andrew, Kirchenbaum, Greg A., Casper, Tamara L., Aydintug, M. Kemal, Carding, Simon R., Ikuta, Koichi, Huang, Hua, Cambier, John C., Wysocki, Lawrence J., O’Brien, Rebecca L., Born, Willi K.

“…Significance This study changes our understanding of the relationship between T cells and B cells. Although it is known that T cells provide help for specific…”
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A Distinctive γδ T Cell Repertoire in NOD Mice Weakens Immune Regulation and Favors Diabetic Disease by O'Brien, Rebecca L, Matsuda, Jennifer, Aydintug, M Kemal, Jin, Niyun, Phalke, Swati, Born, Willi K

“…Previous studies in mice and humans suggesting that T cells play a role in the development of type 1 diabetes have been inconsistent and contradictory. We…”
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γδ T cells recognize the insulin B:9–23 peptide antigen when it is dimerized through thiol oxidation by Kemal Aydintug, M., Zhang, Li, Wang, Chao, Liang, Dongchun, Wands, J.M., Michels, Aaron W., Hirsch, Brooke, Day, Brian J., Zhang, Gongyi, Sun, Deming, Eisenbarth, George S., O’Brien, Rebecca L., Born, Willi K.

“…•Gamma delta T cells specifically respond to the insulin peptide B:9–23.•The response requires dimerization of the peptide via thiol oxidation.•The oxidized…”
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Distribution and leukocyte contacts of γδ T cells in the lung by Wands, J. M., Roark, Christina L., Aydintug, M. Kemal, Jin, Niyun, Hahn, Youn‐Soo, Cook, Laura, Yin, Xiang, Dal Porto, Joseph, Lahn, Michael, Hyde, Dallas M., Gelfand, Erwin W., Mason, Robert J., O’Brien, Rebecca L., Born, Willi K.

“…Pulmonary γδ T cells protect the lung and its functions, but little is known about their distribution in this organ and their relationship to other pulmonary…”
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Subset-specific, uniform activation among Vγ6/Vδ1+ γδ T cells elicited by inflammation by Roark, Christina L., Aydintug, M. Kemal, Lewis, Julie, Yin, Xiang, Lahn, Michael, Hahn, Youn‐Soo, Born, Willi K., Tigelaar, Robert E., O’Brien, Rebecca L.

“…The Vγ6/Vδ1+ cells, the second murine γδ T cell subset to arise in the thymus, express a nearly invariant T cell receptor (TCR), colonize select tissues, and…”
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Protective Role of γδ T Cells in Spontaneous Ocular Inflammation by O'BRIEN, Rebecca L, TAYLOR, Molly A, HARTLEY, Jacqueline, NUHSBAUM, Tanja, DUGAN, Steve, LAHMERS, Kevin, KEMAL AYDINTUG, M, WANDS, J. M, ROARK, Christina L, BORN, Willi K

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Diversity of γδ T-cell antigens by Born, Willi K, Kemal Aydintug, M, O'Brien, Rebecca L

“…In the last two decades, it has become clear that γδ T cells recognize a diverse array of antigens including self and foreign, large and small, and peptidic…”
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Effect of Microbial Heat Shock Proteins on Airway Inflammation and Hyperresponsiveness by Rha, Yeong-Ho, Taube, Christian, Haczku, Angela, Joetham, Anthony, Takeda, Katsuyuki, Duez, Catherine, Siegel, Marvin, Aydintug, M. Kemal, Born, Willi K, Dakhama, Azzeddine, Gelfand, Erwin W

“…Microbial heat shock proteins (hsp) have been associated with the generation and induction of Th1-type immune responses. We tested the effects of treatment…”
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γδ T Cells Shape Preimmune Peripheral B Cell Populations by Huang, Yafei, Getahun, Andrew, Heiser, Ryan A, Detanico, Thiago O, Aviszus, Katja, Kirchenbaum, Greg A, Casper, Tamara L, Huang, Chunjian, Aydintug, M Kemal, Carding, Simon R, Ikuta, Koichi, Huang, Hua, Wysocki, Lawrence J, Cambier, John C, O'Brien, Rebecca L, Born, Willi K

“…We previously reported that selective ablation of certain γδ T cell subsets, rather than removal of all γδ T cells, strongly affects serum Ab levels in…”
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gamma delta T cells affect IL-4 production and B-cell tolerance by Huang, Yafei, Heiser, Ryan A, Detanico, Thiago O, Getahun, Andrew, Kirchenbaum, Greg A, Casper, Tamara L, Aydintug, M Kemal, Carding, Simon R, Ikuta, Koichi, Huang, Hua, Cambier, John C, Wysocki, Lawrence J, O'Brien, Rebecca L, Born, Willi K

“… T cells can influence specific antibody responses. Here, we report that mice deficient in individual ... T-cell subsets have altered levels of serum…”
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A canonical Vγ4Vδ4+ γδ T cell population with distinct stimulation requirements which promotes the Th17 response by Roark, Christina L., Huang, Yafei, Jin, Niyun, Aydintug, M. Kemal, Casper, Tamara, Sun, Deming, Born, Willi K., O’Brien, Rebecca L.

“…We previously reported a subset of γδ T cells in mice which preferentially responds following intradermal immunization with collagen in complete Freund’s…”
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γδ T-cell receptors: functional correlations by O'Brien, Rebecca L, Roark, Christina L, Jin, Niyun, Kemal Aydintug, M, French, Jena D, Chain, Jennifer L, Wands, J.M, Johnston, Molly, Born, Willi K

“…The γδ T-cell receptors (TCRs) are limited in their diversity, suggesting that their natural ligands may be few in number. Ligands for γδTCRs that have thus…”
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gamma delta T-cell receptors: functional correlations by O'Brien, Rebecca L, Roark, Christina L, Jin, Niyun, Kemal Aydintug, M, French, Jena D, Chain, Jennifer L, Wands, J M, Johnston, Molly, Born, Willi K

“…The gamma delta T-cell receptors (TCRs) are limited in their diversity, suggesting that their natural ligands may be few in number. Ligands for gamma delta…”
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Peptide antigens for gamma/delta T cells by Born, Willi K., Zhang, Li, Nakayama, Maki, Jin, Niyun, Chain, Jennifer L., Huang, Yafei, Aydintug, M. Kemal, O’Brien, Rebecca L.

“…γδ T cells express adaptive antigen receptors encoded by rearranging genes. Their diversity is highest in the small region of TCR V–J junctions, especially in…”
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Aerosolized anti-T-cell-receptor antibodies are effective against airway inflammation and hyperreactivity by Lahn, Michael, Kanehiro, Arihiko, Hahn, Youn-Soo, Wands, J M, Aydintug, M Kemal, O'Brien, Rebecca L, Gelfand, Erwin W, Born, Willi K

“…Aerosolized monoclonal antibodies (mAbs) specific for T-cell receptors (TCR) were used to manipulate T-cell function in airways of ovalbumin (OVA)-sensitized…”
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Antigen-specific regulation of IgE antibodies by non-antigen-specific γδ T cells by Huang, Yafei, Aydintug, M Kemal, Loomis, Joshua, Macleod, Megan K, McKee, Amy S, Kirchenbaum, Greg, Jakubzick, Claudia V, Kedl, Ross M, Sun, Deming, Jacobelli, Jordan, O'Brien, Rebecca L, Born, Willi K

“…We re-examined the observation that γδ T cells, when transferred from mice tolerized to an inhaled conventional Ag, suppress the allergic IgE response to this…”
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αβ TCR⁺ T cells, but not B cells, promote autoimmune keratitis in b10 mice lacking γδ T cells by O'Brien, Rebecca L, Chain, Jennifer L, Aydintug, M Kemal, Bohrer-Kunter, Dawn, Huang, Yafei, Hardy, Ian R, Cambier, John C, Lahmers, Kevin, Nuhsbaum, Tanja, Davidson, Richard, Sun, Deming, Born, Willi K

“…To investigate additional factors in the spontaneous development of keratitis previously reported in B10.TCRδ⁻/⁻ female mice. The study tested whether…”
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Detection of Cell Surface Ligands for the γδ TCR Using Soluble TCRs by Aydintug, M. Kemal, Roark, Christina L., Yin, Xiang, Wands, J. M., Born, Willi K., O’Brien, Rebecca L.

“…Abstract The natural ligands recognized by γδ TCRs are still largely unknown, in part because immunization does not normally result in Ag-specific γδ T cell…”
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MHC class I-dependent Vγ4+ pulmonary T cells regulate αβ T cell-independent airway responsiveness by Lahn, Michael, Kanehiro, Arihiko, Takeda, Katsuyuki, Terry, Jennifer, Hahn, Youn-Soo, Aydintug, M. Kemal, Konowal, Anatole, Ikuta, Koichi, O'Brien, Rebecca L., Gelfand, Erwin W., Born, Willi K.

“…Mice exposed to aerosolized ovalbumin (OVA) develop increased airway responsiveness when deficient in γδ T cells. This finding suggests that γδ T cells…”
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Reversal of allergic airway hyperreactivity after long-term allergen challenge depends on γδ T cells by CUI, Zhi-Hua, JOETHAM, Anthony, KEMAL AYDINTUG, M, HAHN, Yoon-Soo, BORN, Willi K, GELFAND, Erwin W

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