Betaine treatment decreased oxidative stress, inflammation, and stellate cell activation in rats with alcoholic liver fibrosis

Highlights • Alcoholic liver fibrosis was induced by ethanol and carbon tetrachloride in rats. • Effect of betaine (BET) on alcoholic liver fibrosis was investigated. • BET supressed oxidative stress, inflammation and hepatic stellate cell activation.

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Bibliographic Details
Published in:	Environmental toxicology and pharmacology Vol. 45; pp. 170 - 178
Main Authors:	Bingül, İlknur, Başaran-Küçükgergin, Canan, Aydın, A.Fatih, Çoban, Jale, Doğan-Ekici, Işın, Doğru-Abbasoğlu, Semra, Uysal, Müjdat
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-07-2016
Subjects:	Alcoholic liver fibrosis Animals Antioxidants - metabolism Betaine Betaine - administration & dosage Betaine - therapeutic use Biomarkers - blood Body Weight - drug effects Emergency Female Hepatic Stellate Cells - drug effects Hepatic Stellate Cells - immunology Hepatic Stellate Cells - metabolism Hepatic Stellate Cells - pathology Lipid Peroxidation - drug effects Liver - drug effects Liver - immunology Liver - metabolism Liver - pathology Liver Cirrhosis, Alcoholic - immunology Liver Cirrhosis, Alcoholic - metabolism Liver Cirrhosis, Alcoholic - pathology Liver Cirrhosis, Alcoholic - prevention & control Liver Cirrhosis, Experimental - immunology Liver Cirrhosis, Experimental - metabolism Liver Cirrhosis, Experimental - pathology Liver Cirrhosis, Experimental - prevention & control Liver Function Tests Organ Size - drug effects Oxidative stress Oxidative Stress - drug effects Rat Rats, Sprague-Dawley Stellate cell activation alcoholic liver fibrosis stellate cell activation rat betaine oxidative stress Alcoholic liver fibrosis Oxidative stress Stellate cell activation Rat Betaine
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Summary:	Highlights • Alcoholic liver fibrosis was induced by ethanol and carbon tetrachloride in rats. • Effect of betaine (BET) on alcoholic liver fibrosis was investigated. • BET supressed oxidative stress, inflammation and hepatic stellate cell activation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2016.05.033