Search Results - "Ayame Saito"

The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites by Schneider, Elena K, McQuade, Rachel M, Carbone, Vincenzo C, Reyes-Ortega, Felisa, Wilson, John W, Button, Brenda, Saito, Ayame, Poole, Daniel P, Hoyer, Daniel, Li, Jian, Velkov, Tony

“…Ivacaftor-lumacaftor and ivacaftor are two new breakthrough cystic fibrosis transmembrane conductance modulators. The interactions of ivacaftor and its two…”
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Therapeutic potential of allosteric modulators for the treatment of gastrointestinal motility disorders by Saito, Ayame, Alvi, Sadia, Valant, Celine, Christopoulos, Arthur, Carbone, Simona E., Poole, Daniel P.

“…Gastrointestinal motility is tightly regulated by the enteric nervous system (ENS). Disruption of coordinated enteric nervous system activity can result in…”
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Gut Analysis Toolbox: Automating quantitative analysis of enteric neurons by Sorensen, Luke, Humenick, Adam, Poon, Sabrina S B, Han, Myat Noe, Mahdavian, Narges S, Rowe, Matthew C, Hamnett, Ryan, Gómez-de-Mariscal, Estibaliz, Neckel, Peter H, Saito, Ayame, Mutunduwe, Keith, Glennan, Christie, Haase, Robert, McQuade, Rachel M, Foong, Jaime P P, Brookes, Simon J H, Kaltschmidt, Julia A, Muñoz-Barrutia, Arrate, King, Sebastian K, Veldhuis, Nicholas A, Carbone, Simona E, Poole, Daniel P, Rajasekhar, Pradeep

“…The enteric nervous system (ENS) consists of an extensive network of neurons and glial cells embedded within the wall of the gastrointestinal (GI) tract…”
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Positive allosteric modulation of endogenous delta opioid receptor signaling in the enteric nervous system is a potential treatment for gastrointestinal motility disorders by DiCello, Jesse J, Carbone, Simona E, Saito, Ayame, Pham, Vi, Szymaszkiewicz, Agata, Gondin, Arisbel B, Alvi, Sadia, Marique, Kiliana, Shenoy, Priyank, Veldhuis, Nicholas A, Fichna, Jakub, Canals, Meritxell, Christopoulos, Arthur, Valant, Celine, Poole, Daniel P

“…Allosteric modulators (AMs) are molecules that can fine-tune signaling by G protein-coupled receptors (GPCRs). Although they are a promising therapeutic…”
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Agonist-dependent development of delta opioid receptor tolerance in the colon by DiCello, Jesse J., Saito, Ayame, Rajasekhar, Pradeep, Sebastian, Benjamin W., McQuade, Rachel M., Gondin, Arisbel B., Veldhuis, Nicholas A., Canals, Meritxell, Carbone, Simona E., Poole, Daniel P.

“…The use of opioid analgesics is severely limited due to the development of intractable constipation, mediated through activation of mu opioid receptors (MOR)…”
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Clathrin and GRK2/3 inhibitors block δ-opioid receptor internalization in myenteric neurons and inhibit neuromuscular transmission in the mouse colon by DiCello, Jesse J, Rajasekhar, Pradeep, Eriksson, Emily M, Saito, Ayame, Gondin, Arisbel B, Veldhuis, Nicholas A, Canals, Meritxell, Carbone, Simona E, Poole, Daniel P

“…Endocytosis is a major mechanism through which cellular signaling by G protein-coupled receptors (GPCRs) is terminated. However, recent studies demonstrate…”
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182 Inflammation-Associated Changes in Delta Opioid Receptor Function and Distribution in the Mouse Colon by Carbone, Simona E, Cello, Jesse Di, Saito, Ayame, Bunnett, Nigel, Canals, Meritxell, Poole, Daniel P

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Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon by DiCello, Jesse J., Carbone, Simona E., Saito, Ayame, Rajasekhar, Pradeep, Ceredig, Rhian A., Pham, Vi, Valant, Celine, Christopoulos, Arthur, Veldhuis, Nicholas A., Canals, Meritxell, Massotte, Dominique, Poole, Daniel P.

“…Functional interactions between the mu opioid receptor (MOR) and delta opioid receptor (DOR) represent a potential target for novel analgesics and may drive…”
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Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse ColonSummary by Jesse J. DiCello, Simona E. Carbone, Ayame Saito, Pradeep Rajasekhar, Rhian A. Ceredig, Vi Pham, Celine Valant, Arthur Christopoulos, Nicholas A. Veldhuis, Meritxell Canals, Dominique Massotte, Daniel P. Poole

“…Background & Aims: Functional interactions between the mu opioid receptor (MOR) and delta opioid receptor (DOR) represent a potential target for novel…”
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