Search Results - "Ayaluru, Murali"

The highly efficient T7 RNA polymerase: A wonder macromolecule in biological realm by Borkotoky, Subhomoi, Murali, Ayaluru

“…The study of bacteriophage has always been of keen interest for biologists to understand the fundamentals of biology. Bacteriophage T7 was first isolated in…”
Get full text

A computational assessment of pH-dependent differential interaction of T7 lysozyme with T7 RNA polymerase by Borkotoky, Subhomoi, Murali, Ayaluru

“…T7 lysozyme (T7L), also known as N-acetylmuramoyl-L-alanine amidase, is a T7 bacteriophage gene product. It involves two functions: It can cut amide bonds in…”
Get full text

Cinnamic acid attenuates quorum sensing associated virulence factors and biofilm formation in Pseudomonas aeruginosa PAO1 by Rajkumari, Jobina, Borkotoky, Subhomoi, Murali, Ayaluru, Suchiang, Kitlangki, Mohanty, Saswat Kumar, Busi, Siddhardha

“…Objective Anti-quorum sensing and anti-biofilm efficacy of Cinnamic acid against Pseudomonas aeruginosa was comparatively assessed with respect to potent…”
Get full text

The Application of MD Simulation to Lead Identification, Vaccine Design, and Structural Studies in Combat against Leishmaniasis - A Review by Vijayakumar, Saravanan, Kumar, Lukkani Laxman, Borkotoky, Subhomoi, Murali, Ayaluru

“…Drug discovery, vaccine design, and protein interaction studies are rapidly moving toward the routine use of molecular dynamics simulations (MDS) and related…”
Get more information

An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4 by Motshwene, Precious G., Moncrieffe, Martin C., Grossmann, J. Günter, Kao, Cheng, Ayaluru, Murali, Sandercock, Alan M., Robinson, Carol V., Latz, Eicke, Gay, Nicholas J.

“…Toll-like receptors (TLRs) mediate responses to pathogen-associated molecules as part of the vertebrate innate immune response to infection. Receptor…”
Get full text

Interaction Analysis of T7 RNA Polymerase with Heparin and Its Low Molecular Weight Derivatives - An In Silico Approach by Borkotoky, Subhomoi, Meena, Chetan Kumar, Murali, Ayaluru

“…The single subunit T7 RNA polymerase (T7RNAP) is a model enzyme for studying the transcription process and for various biochemical and biophysical studies…”
Get full text

Role of Surface Charge Density in Nanoparticle-Templated Assembly of Bromovirus Protein Cages by Daniel, Marie-Christine, Tsvetkova, Irina B., Quinkert, Zachary T., Murali, Ayaluru, De, Mrinmoy, Rotello, Vincent M., Kao, C. Cheng, Dragnea, Bogdan

“…Self-assembling icosahedral protein cages have potencially useful physical and chemical characteristics for a variety of nanotechnology applications, ranging…”
Get full text

An in-silico glimpse into the pH dependent structural changes of T7 RNA polymerase: a protein with simplicity by Borkotoky, Subhomoi, Kumar Meena, Chetan, Bhalerao, Gopalkrishna M., Murali, Ayaluru

“…The capability of performing an array of functions with its single subunit structure makes T7 RNA polymerase (T7RNAP) as one of the simplest yet attractive…”
Get full text

Core-controlled polymorphism in virus-like particles by Sun, Jingchuan, DuFort, Chris, Daniel, Marie-Christine, Murali, Ayaluru, Chen, Chao, Gopinath, Kodetham, Stein, Barry, De, Mrinmoy, Rotello, Vincent M, Holzenburg, Andreas, Kao, C. Cheng, Dragnea, Bogdan

“…This study concerns the self-assembly of virus-like particles (VLPs) composed of an icosahedral virus protein coat encapsulating a functionalized spherical…”
Get full text

2,4-Di-Tert-Butylphenol Isolated From an Endophytic Fungus, Daldinia eschscholtzii, Reduces Virulence and Quorum Sensing in Pseudomonas aeruginosa by Mishra, Rashmi, Kushveer, Jai Shanti, Khan, Mohd. Imran K., Pagal, Sudhakar, Meena, Chetan Kumar, Murali, Ayaluru, Dhayalan, Arunkumar, Venkateswara Sarma, Vemuri

“…Pseudomonas aeruginosa is among the top three gram-negative bacteria according to the WHO’s critical priority list of pathogens against which newer antibiotics…”
Get full text

RNA-binding proteins that inhibit RNA virus infection by Zhu, Jian, Gopinath, Kodetham, Murali, Ayaluru, Yi, Guanghui, Hayward, S. Diane, Zhu, Heng, Kao, Cheng

“…Arrays of >5,000 Saccharomyces cerevisiae proteins were screened to identify proteins that can preferentially bind a small RNA hairpin that contains a clamped…”
Get full text

Structure and Function of LGP2, a DEX(D/H) Helicase That Regulates the Innate Immunity Response by Murali, Ayaluru, Li, Xiaojun, Ranjith-Kumar, C.T., Bhardwaj, Kanchan, Holzenburg, Andreas, Li, Pingwei, Kao, C. Cheng

“…RNA recognition receptors are important for detection of and response to viral infections. RIG-I and MDA5 are cytoplasmic DEX(D/H) helicase proteins that can…”
Get full text

Agonist and Antagonist Recognition by RIG-I, a Cytoplasmic Innate Immunity Receptor by Ranjith-Kumar, C.T., Murali, Ayaluru, Dong, Wen, Srisathiyanarayanan, Dharmaiah, Vaughan, Robert, Ortiz-Alacantara, Joanna, Bhardwaj, Kanchan, Li, Xiaojun, Li, Pingwei, Kao, Cheng C.

“…Cytoplasmic RNA receptors are important in the detection of and response to viral infections. We analyzed ligand recognition by the retinoic acid-inducible…”
Get full text

Effects of Amino-Acid Substitutions in the Brome mosaic virus Capsid Protein on RNA Encapsidation by Hema, Masarapu, Murali, Ayaluru, Ni, Peng, Vaughan, Robert C, Fujisaki, Koki, Tsvetkova, Irina, Dragnea, Bogdan, Kao, C. Cheng

“…Brome mosaic virus (BMV) packages its genomic RNAs (RNA1, RNA2, and RNA3) and subgenomic RNA4 into three different particles. However, since the RNAs in the…”
Get full text

Separate Metal Requirements for Loop Interactions and Catalysis in the Extended Hammerhead Ribozyme by Kim, Nak-Kyoon, Murali, Ayaluru, DeRose, Victoria J

“…An extended hammerhead ribozyme derived from Schistosoma mansoni, including conserved loops in stems I and II, has been examined to directly monitor the…”
Get full text

The Arabidopsis Stress Responsive Gene Database by Borkotoky, Subhomoi, Saravanan, Vijayakumar, Jaiswal, Amit, Das, Bipul, Selvaraj, Suresh, Murali, Ayaluru, Lakshmi, P. T. V.

“…Plants in nature may face a wide range of favorable or unfavorable biotic and abiotic factors during their life cycle. Any of these factors may cause stress in…”
Get full text

Normal mode analysis and comparative study of intrinsic dynamics of alcohol oxidase enzymes from GMC protein family by Khan, Mohammad Wahab, Murali, Ayaluru

“…Glucose-Methanol-Choline (GMC) family enzymes are very important in catalyzing the oxidation of a wide range of structurally diverse substrates. Enzymes that…”
Get full text

pH modulates the role of SP6 RNA polymerase in transcription process: an in silico study by Singh, Satya Ranjan, Murali, Ayaluru

“…SP6 RNA polymerase (SP6 RNAP) is an essential enzyme for the transcription process in SP6 bacteriophage. SP6 RNAP plays a vital role in mRNA vaccine designing…”
Get full text

Exploring the interaction between Fe3+ and REGLE motif of the high-affinity iron permease (Ftr1): an in silico approach by Choudhury, Ahana Roy, Murali, Ayaluru

“…Mucormycosis is an invasive fungal infection with high mortality rate in immunocompromised individuals. Due to COVID-19 pandemic, the disease has resurfaced…”
Get full text

Conformations of the monomeric hepatitis C virus RNA-dependent RNA polymerase by Kao

“…The hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) changes its conformation and oligomerization state in association with the steps in RNA…”
Get full text