Search Results - "Ayad Ayad Al-Hamashi"

Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner by Fedorka, Sara R, So, Kevin, Al-Hamashi, Ayad A, Gad, Ibtissam, Shah, Ronit, Kholodovych, Veronika, Alqahtani, Hanan D, Taylor, William R, Tillekeratne, L M Viranga

“…In the course of generating a library of open-chain epothilones, we discovered a new class of small molecule anticancer agents that has no effect on tubulin…”
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A Pan-Inhibitor for Protein Arginine Methyltransferase Family Enzymes by Iyamu, Iredia D, Al-Hamashi, Ayad A, Huang, Rong

“…Protein arginine methyltransferases (PRMTs) play important roles in transcription, splicing, DNA damage repair, RNA biology, and cellular metabolism. Thus,…”
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Non-Histone Arginine Methylation by Protein Arginine Methyltransferases by Al-Hamashi, Ayad A, Diaz, Krystal, Huang, Rong

“…Protein arginine methyltransferase (PRMT) enzymes play a crucial role in RNA splicing, DNA damage repair, cell signaling, and differentiation. Arginine…”
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Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5 by Al-Hamashi, Ayad A., Chen, Dongxing, Deng, Youchao, Dong, Guangping, Huang, Rong

“…Protein arginine methyltransferases (PRMTs) have been implicated in the progression of many diseases. Understanding substrate recognition and specificity of…”
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Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells by Taylor, William R., Fedorka, Sara R., Gad, Ibtissam, Shah, Ronit, Alqahtani, Hanan D., Koranne, Radhika, Kuganesan, Nishanth, Dlamini, Samkeliso, Rogers, Tim, Al-Hamashi, Ayad, Kholodovych, Veronika, Barudi, Yusuf, Junk, Damian, Rashid, Maisha S., Jackson, Mark W., Tillekeratne, L. M. Viranga

“…Effective management of advanced cancer requires systemic treatment including small molecules that target unique features of aggressive tumor cells. At the…”
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In Search of Selectivity: Design, Synthesis, and Biological Evaluation of New Classes of HDAC Inhibitors by L. M. Viranga Tillekeratne, Ayad Ayad Al-Hamashi, Samkeliso Dlamini, William Taylor, Radhika Koranne, Mary Kay Pflum, Ahmed T. Negmeldin, Joseph Knoff

“…Epigenetic regulation of gene expression without changing DNA sequences is a promising strategy in developing therapeutic agents for human diseases, especially…”
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Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue by Almaliti, Jehad, Al-Hamashi, Ayad A, Negmeldin, Ahmed T, Hanigan, Christin L, Perera, Lalith, Pflum, Mary Kay H, Casero, Robert A, Tillekeratne, L. M. Viranga

“…A number of analogues of the marine-derived histone deacetylase inhibitor largazole incorporating major structural changes in the depsipeptide ring were…”
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A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics by Al-Hamashi, Ayad A., Koranne, Radhika, Dlamini, Samkeliso, Alqahtani, Abdulateef, Karaj, Endri, Rashid, Maisha S., Knoff, Joseph R., Dunworth, Matthew, Pflum, Mary Kay H., Casero, Robert A., Perera, Lalith, Taylor, William R., Tillekeratne, L.M. Viranga

“…[Display omitted] •Synthesis of chalcone mimics containing an imidazole-based metal-binding group intended for HDAC inhibition.•Compounds showed cytotoxicity…”
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A Bioactive Resveratrol Trimer from the Stem Bark of the Sri Lankan Endemic Plant Vateria copallifera by Samaradivakara, Saroopa P, Samarasekera, Radhika, Handunnetti, Shiroma M, Weerasena, O. V. D. S. Jagathpriya, Al-Hamashi, Ayad A, Slama, James T, Taylor, William R, Alhadidi, Qasim, Shah, Zahoor A, Perera, Lalith, Tillekeratne, L. M. Viranga

“…A new resveratrol trimer, vateriferol (1), having four cis-oriented methine protons and constituting four contiguous stereocenters, was isolated from the bark…”
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Phytosterol Profile in Iraqi Lactuca serriola after Purification and Isolation by Combiflash and HPLC (Conference Paper ) by Murtadha Saleh Hussien, Ayad A. Al-Hamashi

“…One of these plants utilized in traditional medicine is Lactuca seriolla Linn., which belongs to the Asteraceae family. It goes by a variety of common names in…”
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Molecular Docking, ADMET Study, Synthesis, Characterization and Preliminary Antiproliferative Activity of Potential Histone Deacetylase Inhibitors with Isoxazole as New Zinc Binding Group by Mohammed Saeed, Ali, Ayad Abed Ali Al-Hamashi

“…Histone acetylation is a highly interesting epigenetic target for drug therapy. Histone deacetylase enzymes (HDACs) are overexpressed in several diseases,…”
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Discovery of New Thiourea Derivatives as Potential SIRT Inhibitors by Abbas, Mohammed Abdullah, Al-Hamashi, Ayad A.

“…Objective: This study aimed to design and synthesize novel thiourea-based compounds targeting Sirtuins (SIRTs), a class of histone deacetylase enzymes…”
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Molecular docking, ADMET, molecular dynamic simulation, synthesis, and preliminary antiproliferative study of 1,2,4- thiadiazole derivatives as possible histone deacetylase inhibitors by Ali, Rusul Mohammed Hasan, Al-Hamashi, Ayad A

“…Purpose: To develop new histone deacetylase (HDAC) inhibitors with thiadiazole moiety as a zincbinding group. Methods: Maestro software was utilized to design…”
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MOLECULAR DOCKING, ADMET, AND MOLECULAR DYNAMICS SIMULATION STUDIES FOR MOLECULES WITH EXPECTED HDAC INHIBITION ACTIVITY

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Design, Synthesis, and Biological Evaluation of Novel Histone Deacetylase Inhibitors as Anti-Cancer Agents by Al-Hamashi, Ayad Abed Ali Chiad A

“…Despite major advances in cancer treatment strategies in recent years, significant limitations still remain. Selectively targeting cancer cells without…”
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