Search Results - "Axelrod, David E."
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Chronotherapy of Early Colon Cancer: Advantage of Morning Dose Schedules
Published in Cancer informatics (01-01-2022)“…Colon adenomas with proliferating mutant cells may progress to invasive carcinomas. Proliferation of cells in human colorectal tissue is circadian, greater in…”
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2
Evolution of Cooperation among Tumor Cells
Published in Proceedings of the National Academy of Sciences - PNAS (05-09-2006)“…The evolution of cooperation has a well established theoretical framework based on game theory. This approach has made valuable contributions to a wide variety…”
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3
Optimization of Dose Schedules for Chemotherapy of Early Colon Cancer Determined by High-Performance Computer Simulations
Published in Cancer informatics (01-01-2019)“…Cancer chemotherapy dose schedules are conventionally applied intermittently, with dose duration of the order of hours, intervals between doses of days or…”
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4
Ecological Therapy for Cancer: Defining Tumors Using an Ecosystem Paradigm Suggests New Opportunities for Novel Cancer Treatments
Published in Translational oncology (01-12-2008)“…We propose that there is an opportunity to devise new cancer therapies based on the recognition that tumors have properties of ecological systems…”
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5
Evaluation of pathways for progression of heterogeneous breast tumors
Published in Journal of theoretical biology (21-01-2005)“…To better understand the progression of heterogeneous breast cancers, four models of progession pathways have been evaluated. The models describe the…”
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A reliable method to determine which candidate chemotherapeutic drugs effectively inhibit tumor growth in patient-derived xenografts (PDX) in single mouse trials
Published in Cancer chemotherapy and pharmacology (01-12-2019)“…Purpose We report on a statistical method for grouping anti-cancer drugs (GRAD) in single mouse trials (SMT). The method assigns candidate drugs into groups…”
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Determining the control networks regulating stem cell lineages in colonic crypts
Published in Journal of theoretical biology (21-09-2017)“…•Numbers of stem cells, TA, and differentiated cells are measured in human crypts.•Stochastic model of control yields 20 simplest possible control networks.•An…”
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Effective chemotherapy of heterogeneous and drug-resistant early colon cancers by intermittent dose schedules: a computer simulation study
Published in Cancer chemotherapy and pharmacology (01-05-2017)“…Purpose The effectiveness of cancer chemotherapy is limited by intra-tumor heterogeneity, the emergence of spontaneous and induced drug-resistant mutant…”
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Combination Chemotherapy of Multidrug-resistant Early-stage Colon Cancer: Determining Optimal Dose Schedules by High-performance Computer Simulation
Published in Cancer research communications (09-01-2023)“…The goal of this project was to utilize mechanistic simulation to demonstrate a methodology that could determine drug combination dose schedules and dose…”
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A calibrated agent-based computer model of stochastic cell dynamics in normal human colon crypts useful for in silico experiments
Published in Theoretical biology and medical modelling (18-11-2013)“…Normal colon crypts consist of stem cells, proliferating cells, and differentiated cells. Abnormal rates of proliferation and differentiation can initiate…”
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Ductal carcinoma in situ of the breast (DCIS) with heterogeneity of nuclear grade: prognostic effects of quantitative nuclear assessment
Published in BMC cancer (10-09-2007)“…Previously, 50% of patients with breast ductal carcinoma in situ (DCIS) had more than one nuclear grade, and neither worst nor predominant nuclear grade was…”
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Effect of Quantitative Nuclear Image Features on Recurrence of Ductal Carcinoma In Situ (DCIS) of the Breast
Published in Cancer informatics (01-01-2008)“…David E. Axelrod1, Naomi A. Miller2, H. Lavina Lickley3, Jin Qian4, William A. Christens-Barry5, Yan Yuan4, Yuejiao Fu6 and Judith-Anne W. Chapman7 1Department…”
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Heterogeneity Between Ducts of the Same Nuclear Grade Involved by Duct Carcinoma In Situ (DCIS) of the Breast
Published in Cancer informatics (07-09-2010)“…Naomi A. Miller1, Judith-Anne W. Chapman2, Jin Qian3, William A. Christens-Barry4, Yuejiao Fu5, Yan Yuan6, H. Lavina A. Lickley7 and David E…”
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Breast cancer prognosis by combinatorial analysis of gene expression data
Published in Breast cancer research : BCR (01-01-2006)“…The potential of applying data analysis tools to microarray data for diagnosis and prognosis is illustrated on the recent breast cancer dataset of van 't Veer…”
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Histopathology as a predictive biomarker: strengths and limitations
Published in The Journal of nutrition (01-10-2006)Get more information
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16
Prognosis for Survival of Young Women with Breast Cancer by Quantitative p53 Immunohistochemistry
Published in Cancer and clinical oncology (01-01-2012)“…p53 protein detected immunohistochemically has not been accepted as a biomarker for breast cancer patients because of disparate reports of the relationship…”
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Avoiding Pitfalls in the Statistical Analysis of Heterogeneous Tumors
Published in Biomedical informatics insights (01-01-2009)“…Information about tumors is usually obtained from a single assessment of a tumor sample, performed at some point in the course of the development and…”
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About-weekly variations in nocturia
Published in Biomedicine & pharmacotherapy (01-10-2004)“…The aim of this study was to assess components of variation in nocturia and to determine any putative geomagnetic influence. A 54-year old man with benign…”
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Journal Article Conference Proceeding -
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A monthly period of symptoms associated with benign prostatic hyperplasia
Published in Urology (Ridgewood, N.J.) (01-03-2000)“…The number of times that a man with benign prostatic hyperplasia awoke each night with the urge to urinate (nocturia) was analyzed for randomness by Bartlett’s…”
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Avoiding Pitfalls in the Statistical Analysis of Heterogeneous Tumors
Published in Biomedical Informatics Insights (01-01-2009)“…David E. Axelrod1, Naomi Miller2 and Judith-Anne W. Chapman31Department of Genetics and Cancer Institute of New Jersey, Rutgers, The State University of New…”
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