Search Results - "Axel, C."

Making Good Decisions in Healthcare with Multi-Criteria Decision Analysis: The Use, Current Research and Future Development of MCDA by Mühlbacher, Axel C., Kaczynski, Anika

“…Healthcare decision making is usually characterized by a low degree of transparency. The demand for transparent decision processes can be fulfilled only when…”
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Patient Preferences Versus Physicians’ Judgement: Does it Make a Difference in Healthcare Decision Making? by Mühlbacher, Axel C., Juhnke, Christin

“…Clinicians and public health experts make evidence-based decisions for individual patients, patient groups and even whole populations. In addition to the…”
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A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome by Polikanov, Yury S, Steitz, Thomas A, Innis, C Axel

“…High-resolution structures of the 70S ribosome from Thermus thermophilus reveal a network of ordered waters in the peptidyl transferase center that suggests a…”
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Patients' preferences: a discrete-choice experiment for treatment of non-small-cell lung cancer by Mühlbacher, Axel C., Bethge, Susanne

“…Objective Lung cancer is a major cause of cancer-related deaths and thus represents a global health problem. According to World Health Organization (WHO)…”
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Patient preferences in the treatment of hemophilia A: A latent class analysis by Mühlbacher, Axel C, Sadler, Andrew, Lamprecht, Björn, Juhnke, Christin

“…To examine subgroup-specific treatment preferences and characteristics of patients with hemophilia A. Best-Worst Scaling (BWS) Case 3 (four attributes:…”
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Comment on the paper "Cost-effectiveness of sofosbuvir in hepatitis C genotype 1 infection in Germany: A reanalysis of published results" by Mühlbacher, Axel C, Sadler, Andrew

“…About the Authors: Axel C. Mühlbacher Roles Conceptualization, Methodology, Project administration, Writing – original draft, Writing – review & editing *…”
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Edwin Ellen Goldmann (1862–1913) by Adam, Rüdiger, Hüntelmann, Axel C.

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The Probabilistic Efficiency Frontier: A Framework for Cost-Effectiveness Analysis in Germany Put into Practice for Hepatitis C Treatment Options by Mühlbacher, Axel C., PhD, Sadler, Andrew, MSc

“…Abstract Background The German Institute for Quality and Efficiency in Health Care (Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen) adapted…”
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Public preferences for the allocation of donor organs for transplantation: A discrete choice experiment by Oedingen, Carina, Bartling, Tim, Schrem, Harald, Mühlbacher, Axel C., Krauth, Christian

“…This study aimed to assess public preferences for the allocation of donor organs in Germany with the focus on ethical principles of distributive justice. We…”
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Population preferences for non-pharmaceutical interventions to control the SARS-CoV-2 pandemic: trade-offs among public health, individual rights, and economics by Mühlbacher, Axel C., Sadler, Andrew, Jordan, Yvonne

“…Problem Policymakers must decide on interventions to control the pandemic. These decisions are driven by weighing the risks and benefits of various…”
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Connecting soundscape to landscape: Which acoustic index best describes landscape configuration? by Fuller, Susan, Axel, Anne C., Tucker, David, Gage, Stuart H.

“…•We examined the soundscape–landscape relationship in eastern Australian forests.•We compared six published acoustic indices.•Three acoustic indices were…”
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Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics by Beckert, Bertrand, Leroy, Elodie C., Sothiselvam, Shanmugapriya, Bock, Lars V., Svetlov, Maxim S., Graf, Michael, Arenz, Stefan, Abdelshahid, Maha, Seip, Britta, Grubmüller, Helmut, Mankin, Alexander S., Innis, C. Axel, Vázquez-Laslop, Nora, Wilson, Daniel N.

“…Macrolides and ketolides comprise a family of clinically important antibiotics that inhibit protein synthesis by binding within the exit tunnel of the…”
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Revisiting the structures of several antibiotics bound to the bacterial ribosome by Bulkley, David, Innis, C. Axel, Blaha, Gregor, Steitz, Thomas A.

“…The increasing prevalence of antibiotic-resistant pathogens reinforces the need for structures of antibiotic-ribosome complexes that are accurate enough to…”
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Proline-rich antimicrobial peptides targeting protein synthesis by Graf, Michael, Mardirossian, Mario, Nguyen, Fabian, Seefeldt, A Carolin, Guichard, Gilles, Scocchi, Marco, Innis, C Axel, Wilson, Daniel N

“…Covering: up to 2017The innate immune system employs a broad array of antimicrobial peptides (AMPs) to attack invading microorganisms. While most AMPs act by…”
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The Dolphin Proline-Rich Antimicrobial Peptide Tur1A Inhibits Protein Synthesis by Targeting the Bacterial Ribosome by Mardirossian, Mario, Pérébaskine, Natacha, Benincasa, Monica, Gambato, Stefano, Hofmann, Sven, Huter, Paul, Müller, Claudia, Hilpert, Kai, Innis, C Axel, Tossi, Alessandro, Wilson, Daniel N

“…Proline-rich antimicrobial peptides (PrAMPs) internalize into susceptible bacteria using specific transporters and interfere with protein synthesis and…”
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Science or Art? Reproducibility of Health Preference Research by Mühlbacher, Axel C.

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Personalized diabetes management: what do patients with diabetes mellitus prefer? A discrete choice experiment by Mühlbacher, Axel C, Sadler, Andrew, Juhnke, Christin

“…Background: There are unresolved procedural and medical problems in the care of diabetes, which cause high costs for health systems. These include the…”
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How Widespread is Metabolite Sensing by Ribosome-Arresting Nascent Peptides? by Seip, Britta, Innis, C. Axel

“…In order to colonize a niche and compete for scarce resources, microorganisms have evolved means to adjust the expression levels of their biosynthetic enzymes…”
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Using the Bacterial Ribosome as a Discovery Platform for Peptide-Based Antibiotics by Charon, Justine, Manteca, Aitor, Innis, C. Axel

“…The threat of bacteria resistant to multiple antibiotics poses a major public health problem requiring immediate and coordinated action worldwide. While…”
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Patient Preferences in the Treatment of Hemophilia A: A Best–Worst Scaling Case 3 Analysis by Mühlbacher, Axel C., Sadler, Andrew, Lamprecht, Björn, Juhnke, Christin

“…To assess patient preferences for benefits and risks in hemophilia A treatment. A systematic literature search and pretest interviews were conducted to…”
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