wingless refines its own expression domain on the Drosophila wing margin. [Erratum: Dec 12, 1996, v. 384 (6609), p. 597.]

The imaginal discs of Drosophila, which give rise to the adult appendages, are patterned during a period of intense cell proliferation. The specification of differing regions occurs in some cases by subdividing the disc epithelium into lineage compartments. However, in most cases precise boundaries...

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Published in:	Nature (London) Vol. 384; no. 6604; pp. 72 - 74
Main Authors:	Rulifson, E.J, Micchelli, C.A, AxeIrod, J.D, Perrimon, N, Blair, S.S
Format:	Journal Article
Language:	English
Published:	London Nature Publishing 07-11-1996 Nature Publishing Group
Subjects:	Adaptor Proteins, Signal Transducing Animals Biological and medical sciences Boundaries Cell Lineage cells Dishevelled Proteins Drosophila Drosophila - embryology Drosophila - genetics Drosophila Proteins embryogenesis Embryology: invertebrates and vertebrates. Teratology Embryonic Induction - genetics Embryonic Induction - physiology Fundamental and applied biological sciences. Psychology gene expression Gene Expression Regulation, Developmental Membrane Proteins - genetics Molecular embryology Phosphoproteins Proteins - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - physiology Receptors, Notch Signal Transduction wings Wings, Animal - embryology Wnt1 Protein Morphogenesis Embryonic development Wing Imaginal disk Regulation(control) Arthropoda Insecta Drosophila Invertebrata Gene expression Diptera Drosophilidae
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Summary:	The imaginal discs of Drosophila, which give rise to the adult appendages, are patterned during a period of intense cell proliferation. The specification of differing regions occurs in some cases by subdividing the disc epithelium into lineage compartments. However, in most cases precise boundaries are formed between different cell types without early compartmentalization. One such boundary occurs between the wingless (wg)-expressing cells of the wing margin and the adjacent proneural cells, which give rise to margin sensory bristles. Here we show that this boundary arises in part by a mechanism of 'self-refinement', by which wingless protein (Wg) represses wg expression in adjacent cells. Cells unable to receive the Wg signal do not resolve the boundary between wg-expressing and proneural cells.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0028-0836 1476-4687
DOI:	10.1038/384072a0