Physical activity and cardiorespiratory fitness are beneficial for white matter in low-fit older adults

Physical activity (PA) and cardiorespiratory fitness (CRF) are associated with better cognitive function in late life, but the neural correlates for these relationships are unclear. To study these correlates, we examined the association of both PA and CRF with measures of white matter (WM) integrity...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 9; p. e107413
Main Authors:	Burzynska, Agnieszka Zofia, Chaddock-Heyman, Laura, Voss, Michelle W, Wong, Chelsea N, Gothe, Neha P, Olson, Erin A, Knecht, Anya, Lewis, Andrew, Monti, Jim M, Cooke, Gillian E, Wojcicki, Thomas R, Fanning, Jason, Chung, Hyondo David, Awick, Elisabeth, McAuley, Edward, Kramer, Arthur F
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 17-09-2014 Public Library of Science (PLoS)
Subjects:	Accelerometers Adults Age Age Factors Aged Aging Biology and Life Sciences Cardiorespiratory fitness Cognition Cognitive ability Correlation analysis Diffusion Tensor Imaging Exercise Female Fitness Humans Insulin resistance Integrity Kinesiology Lesions Life Style Lifestyles Magnetic resonance imaging Male Medicine and Health Sciences Metabolism Middle Aged Motor Activity Older people Parahippocampal gyrus Physical activity Physical Fitness Physiology Public health Rodents Science Sedentary Behavior Sex Factors Studies Substantia alba White Matter - physiology
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Summary:	Physical activity (PA) and cardiorespiratory fitness (CRF) are associated with better cognitive function in late life, but the neural correlates for these relationships are unclear. To study these correlates, we examined the association of both PA and CRF with measures of white matter (WM) integrity in 88 healthy low-fit adults (age 60-78). Using accelerometry, we objectively measured sedentary behavior, light PA, and moderate to vigorous PA (MV-PA) over a week. We showed that greater MV-PA was related to lower volume of WM lesions. The association between PA and WM microstructural integrity (measured with diffusion tensor imaging) was region-specific: light PA was related to temporal WM, while sedentary behavior was associated with lower integrity in the parahippocampal WM. Our findings highlight that engaging in PA of various intensity in parallel with avoiding sedentariness are important in maintaining WM health in older age, supporting public health recommendations that emphasize the importance of active lifestyle.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conceived and designed the experiments: MWV AFK EM. Performed the experiments: AZB GEC JM CNW NPG EAO AK AL TRW JF HDC EA. Analyzed the data: AZB. Contributed reagents/materials/analysis tools: AZB CNW. Wrote the paper: AZB LCH MWV AFK. Competing Interests: The authors have declared that no competing interests exist.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0107413