Brainstem Infiltration Predicts Survival in Patients With High-grade Gliomas Treated With Chemoradiotherapy

Brainstem Infiltration Predicts Survival in Patients With High-grade Gliomas Treated With Chemoradiotherapy

High-grade gliomas have a poor prognosis despite standard treatment. The aim of the study was to identify new prognostic factors to select patients who need more intense treatment. Forty-three consecutive patients underwent surgery plus chemoradiotherapy for pathologically diagnosed high-grade gliom...

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Bibliographic Details
Published in:Anticancer research Vol. 41; no. 5; pp. 2583 - 2589
Main Authors: Anami, Shimpei, Fukai, Junya, Hama, Mizuki, Awaya, Azusa, Inagaki, Takaya, Chiba, Takahiro, Noda, Yasutaka, Kanemura, Yonehiro, Nakao, Naoyuki, Sonomura, Tetsuo
Format: Journal Article
Language:English
Published: Greece International Institute of Anticancer Research 01-05-2021
Subjects:
Basal ganglia
Brain stem
Chemoradiotherapy
Chemotherapy
Ganglia
Glioma
Infiltration
Medical prognosis
Multivariate analysis
Patients
Prognosis
Radiation therapy
Surgery
Survival
basal ganglia
brainstem infiltration
Predictor of survival
MGMT promoter
high-grade glioma
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Summary:High-grade gliomas have a poor prognosis despite standard treatment. The aim of the study was to identify new prognostic factors to select patients who need more intense treatment. Forty-three consecutive patients underwent surgery plus chemoradiotherapy for pathologically diagnosed high-grade gliomas (grade III, IV). The median survival time was 989 days, and the 1-year survival rate was 87.6%. Among patients with grade IV disease, the median survival time, 1-year, and 2-year survival rate were 814 days, 82.6%, and 58.7%, respectively. In the univariate analysis, unmethylated MGMT promoter (p=0.0495), brainstem infiltration (p=0.0004), basal ganglia as the primary lesion site (p=0.0056), 3-dimensional conformal radiotherapy (p=0.0286), and <50 Gy (p=0.0049) were associated with a poor prognosis. In the multivariate analysis, only brainstem infiltration retained significance (HR for death, 0.21; 95% CI=0.06-0.70; p=0.011). Brainstem infiltration is a novel prognostic factor for poor prognosis in patients with high-grade gliomas.
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ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.15037