Search Results - "Awasthi, Divya"

Identification of Novel Chemical Scaffolds that Inhibit the Growth of Mycobacterium tuberculosis in Macrophages by Ahmed, Sara, Manning, Alyssa, Flint, Lindsay, Awasthi, Divya, Ovechkina, Yulia, Parish, Tanya

“…is an important global pathogen for which new drugs are urgently required. The ability of the organism to survive and multiply within macrophages may…”
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High content, high-throughput screening for small molecule inducers of NF-κB translocation by Njikan, Samuel, Manning, Alyssa J, Ovechkina, Yulia, Awasthi, Divya, Parish, Tanya

“…NF-κB is an important mediator of immune activity and its activation is essential in mounting immune response to pathogens. Here, we describe the optimization…”
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Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA by Kumar, Pradeep, Capodagli, Glenn C, Awasthi, Divya, Shrestha, Riju, Maharaja, Karishma, Sukheja, Paridhi, Li, Shao-Gang, Inoyama, Daigo, Zimmerman, Matthew, Ho Liang, Hsin Pin, Sarathy, Jansy, Mina, Marizel, Rasic, George, Russo, Riccardo, Perryman, Alexander L, Richmann, Todd, Gupta, Aditi, Singleton, Eric, Verma, Sheetal, Husain, Seema, Soteropoulos, Patricia, Wang, Zhe, Morris, Roxanne, Porter, Gene, Agnihotri, Gautam, Salgame, Padmini, Ekins, Sean, Rhee, Kyu Y, Connell, Nancy, Dartois, Véronique, Neiditch, Matthew B, Freundlich, Joel S, Alland, David

“…We report GSK3011724A (DG167) as a binary inhibitor of β-ketoacyl-ACP synthase (KasA) in Genetic and biochemical studies established KasA as the primary…”
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Therapeutic potential of FtsZ inhibition: a patent perspective by Awasthi, Divya, Kumar, Kunal, Ojima, Iwao

“…Filamentous temperature sensitive mutant Z (FtsZ), an essential protein for bacterial cell division, has emerged as an attractive therapeutic target for the…”
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Chemical Exploration of a Highly Selective Scaffold with Activity against Intracellular Mycobacterium tuberculosis by Njikan, Samuel, Ahmed, Sara, Manning, Alyssa, Awasthi, Divya, Ovechkina, Yulia, Chowdhury, Sultan, Butts, Arielle, Parish, Tanya

“…We previously identified a phenylthiourea series with activity against intracellular Mycobacterium tuberculosis using a high-throughput, high-content assay. We…”
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A trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacterium tuberculosis by Knudson, Susan E, Awasthi, Divya, Kumar, Kunal, Carreau, Alexandra, Goullieux, Laurent, Lagrange, Sophie, Vermet, Hélèn, Ojima, Iwao, Slayden, Richard A

“…Trisubstituted benzimidazoles have demonstrated potency against Gram-positive and Gram-negative bacterial pathogens. Previously, a library of novel…”
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Laparoscopic-Assisted Uterovaginal Anastomosis in Congenital Atresia of Uterine Cervix: Follow-up Study by Kriplani, Alka, MD, FRCOG, FICOG, FIMSA, Kachhawa, Garima, MS, FIMSA, Awasthi, Divya, MS, Kulshrestha, Vidushi, MS, FICOG, FIMSA

“…Abstract Study Objective To study the efficacy, safety, and functional outcomes of laparoscopic-assisted uterovaginal anastomosis with placement of a silicone…”
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Natural orifice transluminal endoscopic surgery (hybrid) cholecystectomy: The Dhillon technique by Dhillon, Kanwarjit Singh, Awasthi, Divya, Dhillon, Arshbir Singh

“…This study presents a novel technique to perform cholecystectomy and assess its outcome and feasibility. This study presents the novel Dhillon technique and…”
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Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis by McNeil, Matthew B., Chettiar, Somsundaram, Awasthi, Divya, Parish, Tanya

“…There is a need for new combination regimens for tuberculosis. Identifying synergistic drug combinations can avoid toxic side effects and reduce treatment…”
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Human papillomavirus deoxyribonucleic acid testing in developed countries by Bhatla, Neerja, MBBS, MD, FICOG, FNAMS, Singla, Shilpa, MBBS, MD, MICOG, Awasthi, Divya, MBBS, MD

“…Cervical cancer has been largely eliminated in developed countries with the implementation of cytology-based screening programmes that depend on a call–recall…”
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Neotectonic Control on the Geomorphic Evolution of the Gangotri Glacier Valley, Garhwal Himalaya by Bali, Rameshwar, Darshan Awasthi, Divya, Tiwari, N.K.

“…The paper records evidences of neotectonic activities in the Gangotri glacier valley that are found to be responsible for the present-day geomorphic set-up of…”
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Antimycobacterial Metabolism: Illuminating Mycobacterium tuberculosis Biology and Drug Discovery by Awasthi, Divya, Freundlich, Joel S

“…Bacteria are capable of performing a number of biotransformations that may activate or deactivate xenobiotics. Recent efforts have utilized metabolomics…”
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Antimycobacterial Metabolism: Illuminating M. tuberculosis Biology and Drug Discovery by Awasthi, Divya, Freundlich, Joel S.

“…Bacteria are capable of performing a number of biotransformations that may activate or deactivate xenobiotics. Recent efforts have utilized metabolomics…”
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Drug discovery targeting cell division proteins, microtubules and FtsZ by Ojima, Iwao, Kumar, Kunal, Awasthi, Divya, Vineberg, Jacob G.

“…Eukaryotic cell division or cytokinesis has been a major target for anticancer drug discovery. After the huge success of paclitaxel and docetaxel,…”
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SAR Studies on Trisubstituted Benzimidazoles as Inhibitors of Mtb FtsZ for the Development of Novel Antitubercular Agents by Awasthi, Divya, Kumar, Kunal, Knudson, Susan E, Slayden, Richard A, Ojima, Iwao

“…FtsZ, an essential protein for bacterial cell division, is a highly promising therapeutic target, especially for the discovery and development of…”
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Strategic incorporation of fluorine in the drug discovery of new-generation antitubercular agents targeting bacterial cell division protein FtsZ by Ojima, Iwao, Awasthi, Divya, Wei, Longfei, Haranahalli, Krupanandan

“…[Display omitted] •Novel fluorine-containing benzimidazoles, targeting M. tuberculosis FtsZ.•Successful strategic incorporations of fluorine and organofluoro…”
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SB-RA-2001 Inhibits Bacterial Proliferation by Targeting FtsZ Assembly by Singh, Dipty, Bhattacharya, Anusri, Rai, Ankit, Dhaked, Hemendra Pal Singh, Awasthi, Divya, Ojima, Iwao, Panda, Dulal

“…FtsZ has been recognized as a promising antimicrobial drug target because of its vital role in bacterial cell division. In this work, we found that a taxane…”
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Novel Trisubstituted Benzimidazoles, Targeting Mtb FtsZ, as a New Class of Antitubercular Agents by Kumar, Kunal, Awasthi, Divya, Lee, Seung-Yub, Zanardi, Ilaria, Ruzsicska, Bela, Knudson, Susan, Tonge, Peter J, Slayden, Richard A, Ojima, Iwao

“…Libraries of novel trisubstituted benzimidazoles were created through rational drug design. A good number of these benzimidazoles exhibited promising MIC…”
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Malignant uterine perivascular epithelioid cell tumor: histopathologic and immunohistochemical characterization of a rare tumor in a post-menopausal woman by Kollabathula, Arpitha, Gupta, Parikshaa, Das, Chandan Krushna, Awasthi, Divya, Srinivasan, Radhika

“…Background: Perivascular epithelioid cell tumors (PEComas) are rare, mesenchymal neoplasms composed of epithelioid cells exhibiting myogenic and melanocytic…”
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High content, high-throughput screening for small molecule inducers of NF-[kappa]B translocation by Njikan, Samuel, Manning, Alyssa J, Ovechkina, Yulia, Awasthi, Divya, Parish, Tanya

“…NF-[kappa]B is an important mediator of immune activity and its activation is essential in mounting immune response to pathogens. Here, we describe the…”
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