Search Results - "Awasthi, C."

Beyond Simple Trend Tests: Detecting Significant Changes in Design‐Flood Quantiles by Awasthi, C., Archfield, S. A., Reich, B. J., Sankarasubramanian, A.

“…Changes in annual maximum flood (AMF), which are usually detected using simple trend tests (e.g., Mann‐Kendall test (MKT)), are expected to change design‐flood…”
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Projecting Flood Frequency Curves Under Near‐Term Climate Change by Awasthi, C., Archfield, S. A., Ryberg, K. R., Kiang, J. E., Sankarasubramanian, A.

“…Flood‐frequency curves, critical for water infrastructure design, are typically developed based on a stationary climate assumption. However, climate changes…”
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4-Hydroxynonenal Induces G2/M Phase Cell Cycle Arrest by Activation of the Ataxia Telangiectasia Mutated and Rad3-related Protein (ATR)/Checkpoint Kinase 1 (Chk1) Signaling Pathway by Chaudhary, Pankaj, Sharma, Rajendra, Sahu, Mukesh, Vishwanatha, Jamboor K., Awasthi, Sanjay, Awasthi, Yogesh C.

“…4-Hydroxynonenal (HNE) has been widely implicated in the mechanisms of oxidant-induced toxicity, but the detrimental effects of HNE associated with DNA damage…”
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Mechanisms of 4-Hydroxy-2-nonenal Induced Pro- and Anti-Apoptotic Signaling by Chaudhary, Pankaj, Sharma, Rajendra, Sharma, Abha, Vatsyayan, Rit, Yadav, Sushma, Singhal, Sharad S, Rauniyar, Navin, Prokai, Laszlo, Awasthi, Sanjay, Awasthi, Yogesh C

“…In recent years, 4-hydroxy-2-nonenal (4-HNE) has emerged as an important second messenger in cell cycle signaling. Here, we demonstrate that 4-HNE induces…”
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Role of the Electrophilic Lipid Peroxidation Product 4-Hydroxynonenal in the Development and Maintenance of Obesity in Mice by Singh, Sharda P, Niemczyk, Maciej, Saini, Deepti, Awasthi, Yogesh C, Zimniak, Ludwika, Zimniak, Piotr

“…The lipid peroxidation product 4-hydroxynonenal (4-HNE) is a signaling mediator with wide-ranging biological effects. In this paper, we report that disruption…”
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Role of SMC1 in overcoming drug resistance in triple negative breast cancer by Yadav, Sushma, Sehrawat, Archana, Eroglu, Zeynep, Somlo, George, Hickey, Robert, Yadav, Sailee, Liu, Xueli, Awasthi, Yogesh C, Awasthi, Sanjay

“…Triple-negative breast cancer (TNBC) is one of the hardest subtypes of breast cancer to treat due to the heterogeneity of the disease and absence of…”
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Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling by Yang, Yusong, Sharma, Rajendra, Sharma, Abha, Awasthi, Sanjay, Awasthi, Yogesh C

“…Role of lipid peroxidation products, particularly 4-hydroxynonenal (4-HNE) in cell cycle signaling is becoming increasingly clear. In this article, recent…”
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Antioxidant role of glutathione S-transferases: protection against oxidant toxicity and regulation of stress-mediated apoptosis by Sharma, Rajendra, Yang, Yusong, Sharma, Abha, Awasthi, Sanjay, Awasthi, Yogesh C

“…It has been known that glutathione S-transferases (GSTs) can reduce lipid hydroperoxides through their Se-independent glutathione peroxidase activity and that…”
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Regression of lung and colon cancer xenografts by depleting or inhibiting RLIP76 (Ral-Binding Protein 1) by SINGHAL, Sharad S, SINGHAL, Jyotsana, YADAV, Sushma, DWIVEDI, Seema, BOOR, Paul J, AWASTHI, Yogesh C, AWASTHI, Sanjay

“…Ral-binding protein 1 (RALBP1) is a stress-responsive and stress-protective multispecific transporter of glutathione conjugates (GS-E) and xenobiotic toxins…”
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RLIP76 and Cancer by Awasthi, Sanjay, Singhal, Sharad S, Awasthi, Yogesh C, Martin, Bryan, Woo, Jung-Hee, Cunningham, C Casey, Frankel, Arthur E

“…RLIP76 is a multifunctional membrane protein that transports glutathione conjugates of electrophilic compounds and other xenobiotics including chemotherapy…”
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Transport of glutathione conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): A novel link between G‐protein and tyrosine kinase signaling and drug resistance by Awasthi, Sanjay, Singhal, Sharad S., Sharma, Rajendra, Zimniak, Piotr, Awasthi, Yogesh C.

“…Our studies have shown that RLIP76 (RALBP1), a 76 kDa Ral‐binding, Rho/Rac‐GAP and Ral effector protein, is a novel multispecific transporter of xenobiotics as…”
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RLIP76 transports vinorelbine and mediates drug resistance in non-small cell lung cancer by STUCKLER, David, SINGHAL, Jyotsana, SINGHAL, Sharad S, YADAV, Sushma, AWASTHI, Yogesh C, AWASTHI, Sanjay

“…Vinorelbine (Navelbine), an amphiphilic semisynthetic Vinca alkaloid, has displayed superior activity and decreased resistance in the treatment of advanced…”
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Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases by Awasthi, Yogesh C, Yang, Yusong, Tiwari, Narendra K, Patrick, Brad, Sharma, Abha, Li, Jie, Awasthi, Sanjay

“…4-Hydroxynonenal (HNE), one of the major end products of lipid peroxidation, has been shown to be involved in signal transduction and available evidence…”
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RLIP76 is a major determinant of radiation sensitivity by AWASTHI, Sanjay, SINGHAL, Sharad S, BOOR, Paul, DWIVEDI, Seema, DENT, Paul, JARMAN, Wendy E, JOHN, Berchmans, AWASTHI, Yogesh C, YADAV, Sushma, SINGHAL, Jyotsana, DRAKE, Kenneth, NADKAR, Aalok, ZAJAC, Ewa, WICKRAMARACHCHI, Dilki, ROWE, Nancy, YACOUB, Adly

“…RLIP76 (RALBP1) is a glutathione-conjugate transporter that is a critical component of clathrin-coated pit-mediated endocytosis, as well as in stress…”
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Regression of melanoma in a murine model by RLIP76 depletion by SINGHAL, Sharad S, AWASTHI, Yogesh C, AWASTHI, Sanjay

“…RLIP76/RALBP1 is a stress-responsive membrane protein implicated in the regulation of multiple cellular signaling pathways. It represents the predominant…”
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Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse by Engle, Mark R, Singh, Sharda P, Czernik, Piotr J, Gaddy, Dana, Montague, Donna C, Ceci, Jeffrey D, Yang, Yusong, Awasthi, Sanjay, Awasthi, Yogesh C, Zimniak, Piotr

“…The lipid peroxidation product 4-hydroxynon-2-enal (4-HNE) is a strong electrophile that forms covalent adducts with proteins and, to a lesser extent, nucleic…”
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Accelerated Metabolism and Exclusion of 4-Hydroxynonenal through Induction of RLIP76 and hGST5.8 Is an Early Adaptive Response of Cells to Heat and Oxidative Stress by Cheng, Ji-Zhong, Sharma, Rajendra, Yang, Yusong, Singhal, Sharad S., Sharma, Abha, Saini, Manjit K., Singh, Shivendra V., Zimniak, Piotr, Awasthi, Sanjay, Awasthi, Yogesh C.

“…To explore the role of lipid peroxidation (LPO) products in the initial phase of stress mediated signaling, we studied the effect of mild, transient oxidative…”
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Role of Lipid Peroxidation in Cellular Responses to d,l-Sulforaphane, a Promising Cancer Chemopreventive Agent by Sharma, Rajendra, Sharma, Abha, Chaudhary, Pankaj, Pearce, Virginia, Vatsyayan, Rit, Singh, Shivendra V, Awasthi, Sanjay, Awasthi, Yogesh C

“…d,l-Sulforaphane (SFN), a synthetic analogue of the broccoli-derived l-isomer, is a highly promising cancer chemopreventive agent substantiated by inhibition…”
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RLIP76, a non-ABC transporter, and drug resistance in epilepsy by Awasthi, Sanjay, Hallene, Kerri L, Fazio, Vince, Singhal, Sharad S, Cucullo, Luca, Awasthi, Yogesh C, Dini, Gabriele, Janigro, Damir

“…Permeability of the blood-brain barrier is one of the factors determining the bioavailability of therapeutic drugs and resistance to chemically different…”
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RLIP76 in Defense of Radiation Poisoning by Singhal, Jyotsana, M.S, Singhal, Sharad S., Ph.D, Yadav, Sushma, Ph.D, Suzuki, Sumihiro, Ph.D, Warnke, Molly M., B.A, Yacoub, Adly, Ph.D, Dent, Paul, Ph.D, Bae, Sejong, Ph.D, Sharma, Rajendra, Ph.D, Awasthi, Yogesh C., Ph.D, Armstrong, Daniel W., Ph.D, Awasthi, Sanjay, M.D

“…Purpose To determine the role of RLIP76 in providing protection from radiation and chemotherapy. In the present report, we used RLIP76 to refer to both the…”
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