Search Results - "Awad, Issam"

Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel by Akers, Amy, Al-Shahi Salman, Rustam, A. Awad, Issam, Dahlem, Kristen, Flemming, Kelly, Hart, Blaine, Kim, Helen, Jusue-Torres, Ignacio, Kondziolka, Douglas, Lee, Cornelia, Morrison, Leslie, Rigamonti, Daniele, Rebeiz, Tania, Tournier-Lasserve, Elisabeth, Waggoner, Darrel, Whitehead, Kevin

“…Abstract BACKGROUND: Despite many publications about cerebral cavernous malformations (CCMs), controversy remains regarding diagnostic and management…”
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Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions by Magid-Bernstein, Jessica, Girard, Romuald, Polster, Sean, Srinath, Abhinav, Romanos, Sharbel, Awad, Issam A., Sansing, Lauren H.

“…Intracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity and mortality. This review article focuses on the epidemiology, cause,…”
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Cavernous angiomas: deconstructing a neurosurgical disease by Awad, Issam A, Polster, Sean P

“…Cavernous angioma (CA) is also known as cavernoma, cavernous hemangioma, and cerebral cavernous malformation (CCM) (National Library of Medicine Medical…”
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Commentary: Feasibility and Morbidity of Magnetic Resonance Imaging-Guided Stereotactic Laser Ablation of Deep Cerebral Cavernous Malformations: A Report of 4 Cases by Awad, Issam A

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Credulity of exploratory trials for cerebral cavernous malformations by Shenkar, Robert, Awad, Issam A

“…Preclinical studies have suggested potential pharmacological strategies that are based on modification of molecular signaling pathways.1 Clinical trials to…”
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Cerebral Cavernous Malformation: From Mechanism to Therapy by Snellings, Daniel A., Hong, Courtney C., Ren, Aileen A., Lopez-Ramirez, Miguel A., Girard, Romuald, Srinath, Abhinav, Marchuk, Douglas A., Ginsberg, Mark H., Awad, Issam A., Kahn, Mark L.

“…Cerebral cavernous malformations are acquired vascular anomalies that constitute a common cause of central nervous system hemorrhage and stroke. The past 2…”
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Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation by Lopez-Ramirez, Miguel Alejandro, Lai, Catherine Chinhchu, Soliman, Shady Ibrahim, Hale, Preston, Pham, Angela, Estrada, Esau J, McCurdy, Sara, Girard, Romuald, Verma, Riya, Moore, Thomas, Lightle, Rhonda, Hobson, Nicholas, Shenkar, Robert, Poulsen, Orit, Haddad, Gabriel G, Daneman, Richard, Gongol, Brendan, Sun, Hao, Lagarrigue, Frederic, Awad, Issam A, Ginsberg, Mark H

“…Cerebral cavernous malformations (CCMs) are common neurovascular lesions caused by loss-of-function mutations in 1 of 3 genes, including KRIT1 (CCM1), CCM2,…”
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External ventricular drain-related infections: dilemmas of definitions, generalisability and associations versus causations by Awad, Issam A

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Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity by Stockton, Rebecca A, Shenkar, Robert, Awad, Issam A, Ginsberg, Mark H

“…Endothelial cell-cell junctions regulate vascular permeability, vasculogenesis, and angiogenesis. Familial cerebral cavernous malformations (CCMs) in humans…”
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PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism by Ren, Aileen A., Snellings, Daniel A., Su, Yourong S., Hong, Courtney C., Castro, Marco, Tang, Alan T., Detter, Matthew R., Hobson, Nicholas, Girard, Romuald, Romanos, Sharbel, Lightle, Rhonda, Moore, Thomas, Shenkar, Robert, Benavides, Christian, Beaman, M. Makenzie, Müller-Fielitz, Helge, Chen, Mei, Mericko, Patricia, Yang, Jisheng, Sung, Derek C., Lawton, Michael T., Ruppert, J. Michael, Schwaninger, Markus, Körbelin, Jakob, Potente, Michael, Awad, Issam A., Marchuk, Douglas A., Kahn, Mark L.

“…Vascular malformations are thought to be monogenic disorders that result in dysregulated growth of blood vessels. In the brain, cerebral cavernous…”
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Endothelial TLR4 and the microbiome drive cerebral cavernous malformations by Tang, Alan T., Choi, Jaesung P., Kotzin, Jonathan J., Yang, Yiqing, Hong, Courtney C., Hobson, Nicholas, Girard, Romuald, Zeineddine, Hussein A., Lightle, Rhonda, Moore, Thomas, Cao, Ying, Shenkar, Robert, Chen, Mei, Mericko, Patricia, Yang, Jisheng, Li, Li, Tanes, Ceylan, Kobuley, Dmytro, Võsa, Urmo, Whitehead, Kevin J., Li, Dean Y., Franke, Lude, Hart, Blaine, Schwaninger, Markus, Henao-Mejia, Jorge, Morrison, Leslie, Kim, Helen, Awad, Issam A., Zheng, Xiangjian, Kahn, Mark L.

“…Cerebral cavernous malformations (CCMs) are a cause of stroke and seizure for which no effective medical therapies yet exist. CCMs arise from the loss of an…”
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Spontaneous Intracerebral and Intraventricular Hemorrhage: Advances in Minimally Invasive Surgery and Thrombolytic Evacuation, and Lessons Learned in Recent Trials by Dey, Mahua, Stadnik, Agnieszka, Awad, Issam A.

“…Abstract Optimal management of spontaneous intracerebral hemorrhage (ICH) remains one of the highly debated areas in the field of neurosurgery. Earlier studies…”
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One-Year Outcome Trajectories and Factors Associated with Functional Recovery Among Survivors of Intracerebral and Intraventricular Hemorrhage With Initial Severe Disability by Shah, Vishank A, Thompson, Richard E, Yenokyan, Gayane, Acosta, Julian N, Avadhani, Radhika, Dlugash, Rachel, McBee, Nichol, Li, Yunke, Hansen, Bjorn M, Ullman, Natalie, Falcone, Guido, Awad, Issam A, Hanley, Daniel F, Ziai, Wendy C

“…Patients who survive severe intracerebral hemorrhage (ICH) and intraventricular hemorrhage (IVH) typically have poor functional outcome in the short term and…”
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Guidelines for the Prevention of Stroke in Women: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association by Bushnell, Cheryl, McCullough, Louise D, Awad, Issam A, Chireau, Monique V, Fedder, Wende N, Furie, Karen L, Howard, Virginia J, Lichtman, Judith H, Lisabeth, Lynda D, Piña, Ileana L, Reeves, Mathew J, Rexrode, Kathryn M, Saposnik, Gustavo, Singh, Vineeta, Towfighi, Amytis, Vaccarino, Viola, Walters, Matthew R

“…PURPOSE—The aim of this statement is to summarize data on stroke risk factors that are unique to and more common in women than men and to expand on the data…”
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Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling by Zhou, Zinan, Tang, Alan T., Wong, Weng-Yew, Bamezai, Sharika, Goddard, Lauren M., Shenkar, Robert, Zhou, Su, Yang, Jisheng, Wright, Alexander C., Foley, Matthew, Arthur, J. Simon C., Whitehead, Kevin J., Awad, Issam A., Li, Dean Y., Zheng, Xiangjian, Kahn, Mark L.

“…Gain of MEKK3 signalling is shown to cause cerebral cavernous malformations (CCMs) via activation of the target genes Klf2 and Klf4 ; endothelial-specific loss…”
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In Reply: Intracerebral Hemorrhage Volume Reduction and Timing of Intervention Versus Functional Benefit and Survival in the MISTIE III and STICH Trials by Polster, Sean P, Awad, Issam A

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In Reply: Surgical Performance Determines Functional Outcome Benefit in the Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation (MISTIE) Procedure by Polster, Sean P, Awad, Issam A

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Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice by Lopez-Ramirez, Miguel Alejandro, Pham, Angela, Girard, Romuald, Wyseure, Tine, Hale, Preston, Yamashita, Atsuki, Koskimäki, Janne, Polster, Sean, Saadat, Laleh, Romero, Ignacio A., Esmon, Charles T., Lagarrigue, Frederic, Awad, Issam A., Mosnier, Laurent O., Ginsberg, Mark H.

“…Cerebral cavernous malformations (CCMs) are common brain vascular dysplasias that are prone to acute and chronic hemorrhage with significant clinical sequelae…”
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Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations by Lopez-Ramirez, Miguel Alejandro, Fonseca, Gregory, Zeineddine, Hussein A, Girard, Romuald, Moore, Thomas, Pham, Angela, Cao, Ying, Shenkar, Robert, de Kreuk, Bart-Jan, Lagarrigue, Frederic, Lawler, Jack, Glass, Christopher K, Awad, Issam A, Ginsberg, Mark H

“…mutations are the most common cause of cerebral cavernous malformation (CCM). Acute gene inactivation in mouse brain microvascular endothelial cells (BMECs)…”
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Biology of vascular malformations of the brain by Leblanc, Gabrielle G, Golanov, Eugene, Awad, Issam A, Young, William L

“…This review discusses recent research on the genetic, molecular, cellular, and developmental mechanisms underlying the etiology of vascular malformations of…”
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