Search Results - "Awad, Gehanne A. S"

Polyethylene Glycol Conjugated Polymeric Nanocapsules for Targeted Delivery of Quercetin to Folate-Expressing Cancer Cells in Vitro and in Vivo by El-Gogary, Riham I, Rubio, Noelia, Wang, Julie Tzu-Wen, Al-Jamal, Wafa’ T, Bourgognon, Maxime, Kafa, Houmam, Naeem, Muniba, Klippstein, Rebecca, Abbate, Vincenzo, Leroux, Frédéric, Bals, Sara, Van Tendeloo, Gustaaf, Kamel, Amany O, Awad, Gehanne A. S, Mortada, Nahed D, Al-Jamal, Khuloud T

“…In this work we describe the formulation and characterization of chemically modified polymeric nanocapsules incorporating the anticancer drug, quercetin, for…”
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Role of edge activators and surface charge in developing ultradeformable vesicles with enhanced skin delivery by El Zaafarany, Ghada M., Awad, Gehanne A.S., Holayel, Samar M., Mortada, Nahed D.

“…Transfersomes are highly efficient edge activator (EA)-based ultraflexible vesicles capable of, non-invasively, trespassing skin by virtue of their high,…”
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Different modalities of NaCl osmogen in biodegradable microspheres for bone deposition of risedronate sodium by alveolar targeting by Nasr, Maha, Awad, Gehanne A.S., Mansour, Samar, Taha, Ismail, Shamy, Abdelhamid Al, Mortada, Nahed D.

“…Effect of varying NaCl concentration in either internal/external phase of the w/o/w emulsion on the morphology of risedronate sodium loaded PLGA microspheres…”
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Preparation, in vitro and in vivo evaluation of stomach-specific metronidazole-loaded alginate beads as local anti- Helicobacter pylori therapy by Ishak, Rania A.H., Awad, Gehanne A.S., Mortada, Nahed D., Nour, Samia A.K.

“…Metronidazole (MZ), a common antibacterial drug used in treatment of H. pylori, was prepared in chitosan-treated alginate beads by the ionotropic gelation…”
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An integrated vitamin E-coated polymer hybrid nanoplatform: A lucrative option for an enhanced in vitro macrophage retention for an anti-hepatitis B therapeutic prospect by Hamdi, Mohamed, Abdel-Bar, Hend Mohamed, Elmowafy, Enas, Al-Jamal, Khuloud T, Awad, Gehanne A S

“…A platform capable of specifically delivering an antiviral drug to the liver infected with hepatitis B is a major concern in hepatology. Vaccination has had a…”
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Identifying lipidic emulsomes for improved oxcarbazepine brain targeting: In vitro and rat in vivo studies by El-Zaafarany, Ghada M., Soliman, Mahmoud E., Mansour, Samar, Awad, Gehanne A.S.

“…[Display omitted] Lipid-based nanovectors offer effective carriers for brain delivery by improving drug potency and reducing off-target effects. Emulsomes are…”
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Phospholipid based colloidal poloxamer–nanocubic vesicles for brain targeting via the nasal route by Salama, Hamed A., Mahmoud, Azza A., Kamel, Amany O., Abdel Hady, Mayssa, Awad, Gehanne A.S.

“…[Display omitted] ► New phospholipid based nanocubic vesicular systems were developed. ► The polymeric non-ionic surfactant, poloxamer was incorporated in its…”
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A Tailored Thermosensitive PLGA-PEG-PLGA/Emulsomes Composite for Enhanced Oxcarbazepine Brain Delivery via the Nasal Route by El-Zaafarany, Ghada M, Soliman, Mahmoud E, Mansour, Samar, Cespi, Marco, Palmieri, Giovanni Filippo, Illum, Lisbeth, Casettari, Luca, Awad, Gehanne A S

“…The use of nanocarrier delivery systems for direct nose to brain drug delivery shows promise for achieving increased brain drug levels as compared to simple…”
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Nasal polysaccharides-glucose regulator microparticles: Optimization, tolerability and antidiabetic activity in rats by Elmowafy, Enas, Osman, Rihab, El-Shamy, Abd El-Hameed A., Awad, Gehanne A.S.

“…•Repaglinide was efficiently incorporated in microparticles made of anionic polysaccharides.•A 32 factorial design was set to study formulation effects on drug…”
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Defining cisplatin incorporation properties in thermosensitive injectable biodegradable hydrogel for sustained delivery and enhanced cytotoxicity by Abdel-Bar, Hend Mohamed, Abdel-Reheem, Amal Youssef, Osman, Rihab, Awad, Gehanne A.S., Mortada, Nahed

“…[Display omitted] Injectable thermoreversible chitosan (CS)/β-glycerophosphate (β-GP) hydrogels were developed for prolonged localized delivery of cisplatin…”
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Tunable Biodegradable Nanocomposite Hydrogel for Improved Cisplatin Efficacy on HCT-116 Colorectal Cancer Cells and Decreased Toxicity in Rats by Abdel-Bar, Hend Mohamed, Osman, Rihab, Abdel-Reheem, Amal Youssef, Mortada, Nahed, Awad, Gehanne A.S

“…This work describes the development of a modified nanocomposite thermosensitive hydrogel for controlled cisplatin release and improved cytotoxicity with…”
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A comparative study of chitosan shielding effect on nano-carriers hydrophilicity and biodistribution by Ishak, Rania A.H., Awad, Gehanne A.S., Zaki, Noha M., El-Shamy, Abd El-Hamid A., Mortada, Nahed D.

“…► Chitosan compared to other shielding materials was exploited for shielding PLA NPs. ► The shielding effect on particles zeta potential and hydrophilicity was…”
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A reliable predictive factorial model for entrapment optimization of a sodium bisphosphonate into biodegradable microspheres by Nasr, Maha, Awad, Gehanne A S, Mansour, Samar, Al Shamy, Abdelhamid, Mortada, Nahed D

“…The aim of this work was to optimize the encapsulation of a third generation bisphosphonate (risedronate sodium RS) into polylactide-co-glycolide (PLGA)…”
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Passive targeting and lung tolerability of enoxaparin microspheres for a sustained antithrombotic activity in rats by Ibrahim, Shaimaa S., Osman, Rihab, Mortada, Nahed D., Geneidy, Ahmed-Shawky, Awad, Gehanne A. S.

“…Pulmonary bed can retain microparticles (MP) larger than their capillaries' diameter, hence we offer a promising way for lung passive targeting following…”
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Wound healing potential of silver nanoparticles embedded in optimized bio-inspired hybridized chitosan soft and dry hydrogel by Abdel-Gawad, Roxane, Osman, Rihab, Awad, Gehanne A.S., Mortada, Nahed

“…Interactive wound dressings combining healing and antimicrobial potentials, besides ensuring patient compliance with a recognized wound care service gained…”
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Anticancer effect of atorvastatin nanostructured polymeric micelles based on stearyl-grafted chitosan by Mekhail, George M., Kamel, Amany O., Awad, Gehanne A.S., Mortada, Nahed D.

“…The purpose of this study was to develop a new therapeutic approach for atorvastatin (ATV) adopting nanostructured polymeric micelles for its controlled…”
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Novel thymoquinone lipidic core nanocapsules with anisamide-polymethacrylate shell for colon cancer cells overexpressing sigma receptors by Ramzy, Lydia, Metwally, Abdelkader A., Nasr, Maha, Awad, Gehanne A. S.

“…The biggest challenge in colorectal cancer therapy is to avoid intestinal drug absorption before reaching the colon, while focusing on tumor specific delivery…”
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Cancer nanotheranostics: A review of the role of conjugated ligands for overexpressed receptors by Ramzy, Lydia, Nasr, Maha, Metwally, Abdelkader A., Awad, Gehanne A.S.

“…Cancer treatment using chemotherapy has many drawbacks because of its non-specificity, in which the chemotherapeutic agent attacks both normal and cancerous…”
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Chitosan-calcium phosphate composite scaffolds for control of post-operative osteomyelitis: Fabrication, characterization, and in vitro–in vivo evaluation by Radwan, Noha H., Nasr, Maha, Ishak, Rania A.H., Abdeltawab, Nourtan F., Awad, Gehanne A.S.

“…•Chitosan-calcium phosphate composites were prepared by in situ precipitation method.•Chitosan-calcium phosphate scaffolds boost cellular…”
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Polypeptide and glycosaminoglycan polysaccharide as stabilizing polymers in nanocrystals for a safe ocular hypotensive effect by Donia, Marwa, Osman, Rihab, Awad, Gehanne A.S., Mortada, Nahed

“…Improved ocular delivery of a poorly soluble anti-glaucoma drug, acetazolamide (ACZ), in a stable nanosuspension (NS) was the main target of the study. The…”
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