Search Results - "Avula, Leela Rani"

Molecular mediators of peritoneal metastasis in pancreatic cancer by Avula, Leela Rani, Hagerty, Brendan, Alewine, Christine

“…Pancreatic cancer is the third leading cause of cancer death in the USA, and pancreatic ductal adenocarcinoma (PDA) constitutes 85% of pancreatic cancer…”
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How organ-on-a-chip is advancing cancer research and oncology - a cancer hallmarks’ perspective by Avula, Leela Rani, Grodzinski, Piotr

“…Despite significant improvements in methodologies behind the development of new anticancer therapies, the path from early-stage drug development through…”
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Expression of corticotropin-releasing factor and urocortins in the normal and Schistosoma mansoni-infected mouse ileum by Buckinx, Roeland, Bagyanszki, Maria, Avula, Leela Rani, Adriaensen, Dirk, Van Nassauw, Luc, Timmermans, Jean-Pierre

“…Corticotropin-releasing factor (CRF) and urocortins (UCNs) are important ligands in the CRF signaling pathways, which are most known for their role in the…”
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Whole-genome microarray analysis and functional characterization reveal distinct gene expression profiles and patterns in two mouse models of ileal inflammation by Avula, Leela Rani, Knapen, Dries, Buckinx, Roeland, Vergauwen, Lucia, Adriaensen, Dirk, Van Nassauw, Luc, Timmermans, Jean-Pierre

“…Although a number of intestinal inflammatory conditions pertain to the ileum, whole-genome gene expression analyses in animal models of ileal inflammation are…”
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Nanotechnology-aided advancement in the combating of cancer metastasis by Avula, Leela Rani, Grodzinski, Piotr

“…Cancer, especially when it has metastasized to different locations in the body, is notoriously difficult to treat. Metastatic cancer accounts for most cancer…”
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Mesothelin Enhances Tumor Vascularity in Newly Forming Pancreatic Peritoneal Metastases by Avula, Leela Rani, Rudloff, Michael, El-Behaedi, Salma, Arons, Danielle, Albalawy, Rakan, Chen, Xiongfong, Zhang, Xianyu, Alewine, Christine

“…Over 90% of pancreatic ductal adenocarcinomas (PDAC) express mesothelin (MSLN). Overexpression or knockdown of MSLN has been implicated in PDAC aggressiveness…”
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Abstract 1449: The molecular dissection of pro-tumorigenic activity of mesothelin in pancreatic cancer by Joseph, Sarah Mary, Avula, Leela Rani, Zhang, Xianyu, Alewine, Christine Campo

“…Mesothelin (MSLN) is a cancer-specific antigen that is differentially expressed in many human cancers, including malignant mesothelioma and pancreatic,…”
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Both NHERF3 and NHERF2 are necessary for multiple aspects of acute regulation of NHE3 by elevated Ca 2+ , cGMP, and lysophosphatidic acid by Avula, Leela Rani, Chen, Tiane, Kovbasnjuk, Olga, Donowitz, Mark

“…The intestinal epithelial brush border Na /H exchanger NHE3 accounts for a large component of intestinal Na absorption. NHE3 is regulated during digestion by…”
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Abstract 3767: Characterization of the protumorigenic role of MSLN in peritoneal metastases in pancreatic cancer by Avula, Leela Rani, Rudloff, Michael, El-Behaedi, Salma, Arons, Danielle, Zhang, Xianyu, Alewine, Christine

“…Peritoneal metastases develop in 70-80% of nonresectable patients with pancreatic cancer, and the onset of clinically significant ascites is associated with…”
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34 – E.Coli Heat Stable Enterotoxin (ST) Inhibition of Nhe3 Occurs by Different Signaling Pathways Downstream of Cyclic Gmp in Murine Jejunum and Caco-2 Cells: A Warning About Assumed Equivalence by Donowitz, Mark, Chen, Tiane, Lin, Ruxian, Sarker, Rafiquel, Cha, Boyoung, Avula, Leela Rani, Tse, Ming

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Unraveling Links between Chronic Inflammation and Long COVID: Workshop Report by Tandon, Pushpa, Abrams, Natalie D, Avula, Leela Rani, Carrick, Danielle M, Chander, Preethi, Divi, Rao L, Dwyer, Johanna T, Gannot, Gallya, Gordiyenko, Nataliya, Liu, Qian, Moon, Kyung, PrabhuDas, Mercy, Singh, Anju, Tilahun, Mulualem E, Satyamitra, Merriline M, Wang, Chiayeng, Warren, Ronald, Liu, Christina H

“…As COVID-19 continues, an increasing number of patients develop long COVID symptoms varying in severity that last for weeks, months, or longer. Symptoms…”
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35 - Anion Secretion is Quantitatively Rather than Qualitatively Different Between Crypt-Like Undifferentiated and Villuslike Differentiated Human Duodenal Enteroid Monolayers by Yin, Jianyi, Tse, Ming, Avula, Leela Rani, Singh, Varsha, de Jonge, Hugo, Donowitz, Mark

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Abstract 104: Identification of the molecular components required for the protumorigenic effect of MSLN in pancreatic cancer by Avula, Leela Rani, Rudloff, Michael, Arons, Danielle, El-Behaedi, Salma, Zhang, Xianyu, Guerin, Theresa, Kozlov, Serguei, Alewine, Christine

“…Mesothelin (MSLN) is a GPI-linked protein expressed in >90% of pancreatic adenocarcinomas (PDAC) but not in healthy pancreas nor in the parenchyma of other…”
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Sorting nexin 27 regulates basal and stimulated brush border trafficking of NHE3 by Singh, Varsha, Yang, Jianbo, Cha, Boyoung, Chen, Tiane-e, Sarker, Rafiquel, Yin, Jianyi, Avula, Leela Rani, Tse, Ming, Donowitz, Mark

“…Sorting nexin 27 (SNX27) contains a PDZ domain that is phylogenetically related to the PDZ domains of the NHERF proteins. Studies on nonepithelial cells have…”
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Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers by Yin, Jianyi, Tse, Chung-Ming, Avula, Leela Rani, Singh, Varsha, Foulke-Abel, Jennifer, de Jonge, Hugo R, Donowitz, Mark

“…Background & Aims Human enteroids present a novel tool to study human intestinal ion transport physiology and pathophysiology. The present study describes the…”
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Abstract 1280: Role of soluble mesothelin in peritoneal metastasis by Panchwagh, Neel M., Ewa, Theressa, Avula, Leela Rani, Joseph, Sarah, Tai, Chin-Hsien, Sevilla, Samantha, Koparde, Vishal, Zhang, Xianyu, Alewine, Christine

“…The cell-surface glycoprotein mesothelin (MSLN) is overexpressed in pancreatic adenocarcinoma (PDAC) and is positively correlated with tumor aggressiveness…”
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Expression and distribution patterns of Mas-related gene receptor subtypes A–H in the mouse intestine: inflammation-induced changes by Avula, Leela Rani, Buckinx, Roeland, Favoreel, Herman, Cox, Eric, Adriaensen, Dirk, Van Nassauw, Luc, Timmermans, Jean-Pierre

“…Mas-related gene (Mrg) receptors constitute a subfamily of G protein-coupled receptors that are implicated in nociception, and are as such considered potential…”
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Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid MonolayersSummary by Jianyi Yin, Chung-Ming Tse, Leela Rani Avula, Varsha Singh, Jennifer Foulke-Abel, Hugo R. de Jonge, Mark Donowitz

“…Background & Aims: Human enteroids present a novel tool to study human intestinal ion transport physiology and pathophysiology. The present study describes the…”
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879 The Mas-Related Gene Receptor MrgD Modulates Mucosal Mast Cell Infiltration During Intestinal Inflammation by Avula, Leela Rani, Buckinx, Roeland, Alpaerts, Katrien H, Adriaensen, Dirk, Nassauw, Luc Van, Timmermans, Jean-Pierre

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Expression and distribution patterns of Mas-related gene receptor subtypes Aâ[euro]"H in the mouse intestine: inflammation-induced changes by Avula, Leela Rani, Buckinx, Roeland, Favoreel, Herman, Cox, Eric, Adriaensen, Dirk, Van Nassauw, Luc, Timmermans, Jean-pierre

“…Mas-related gene (Mrg) receptors constitute a subfamily of G protein-coupled receptors that are implicated in nociception, and are as such considered potential…”
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