Search Results - "Avti, Pramod K."

Allosteric modulation of conserved motifs and helices in 5HT2BR: Advances drug discovery and therapeutic approach towards drug resistant epilepsy by Chauhan, Arushi, Sangwan, Namrata, Singh, Jitender, Prakash, Ajay, Medhi, Bikash, Avti, Pramod K.

“…The 5HT 2B R, class-A GPCR is a new target, and its significance for seizure reduction in Dravet syndrome is just now gaining interest, suggesting its specific…”
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Alkyne-azide "click" chemistry in designing nanocarriers for applications in biology by Avti, Pramod K, Maysinger, Dusica, Kakkar, Ashok

“…The alkyne-azide cycloaddition, popularly known as the "click" reaction, has been extensively exploited in molecule/macromolecule build-up, and has offered…”
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Unravelling benzazepines and aminopyrimidine as multi-target therapeutic repurposing drugs for EGFR V774M mutation in neuroglioma patients by Singh, Jitender, Khanduja, Krishan L, Avti, Pramod K

“…Introduction: Neuroglioma, a classification encompassing tumors arising from glial cells, exhibits variable aggressiveness and depends on tumor grade and…”
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Toward Carbon-Nanotube-Based Theranostic Agents for Microwave Detection and Treatment of Breast Cancer: Enhanced Dielectric and Heating Response of Tissue-Mimicking Materials by Mashal, Alireza, Sitharaman, Balaji, Li, Xu, Avti, Pramod K., Sahakian, Alan V., Booske, John H., Hagness, Susan C.

“…The experimental results reported in this paper suggest that single-walled carbon nanotubes (SWCNTs) have the potential to enhance dielectric contrast between…”
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Bimetallic nanoparticles green synthesis from litchi leaf extract: a promising approach for breast cancer treatment by Kaur, Ramanjeet, Singh, Jitender, Avti, Pramod K, Kumar, Vivek, Kumar, Rajesh

“…Abstract Noble metal nanoparticles have demonstrated promising biomedical and nanomedicine applications, and their bimetallic equivalents from the green…”
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Detection, mapping, and quantification of single walled carbon nanotubes in histological specimens with photoacoustic microscopy by Avti, Pramod K, Hu, Song, Favazza, Christopher, Mikos, Antonios G, Jansen, John A, Shroyer, Kenneth R, Wang, Lihong V, Sitharaman, Balaji

“…In the present study, the efficacy of multi-scale photoacoustic microscopy (PAM) was investigated to detect, map, and quantify trace amounts [nanograms (ng) to…”
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Toward single-walled carbon nanotube-gadolinium complex as advanced MRI contrast agents: Pharmacodynamics and global genomic response in small animals by Avti, Pramod K., Talukdar, Yahfi, Sirotkin, Matvey V., Shroyer, Kenneth R., Sitharaman, Balaji

“…Gadolinium nanoparticle‐catalyzed single‐walled carbon nanotubes (Gd‐SWCNTs) have recently shown potential in vitro as high‐performance T1 magnetic resonance…”
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Geraniol and Citral as potential therapeutic agents targeting the HSP90 activity: An in silico and experimental approach by Gaonkar, Roopa, Singh, Jitender, Chauhan, Arushi, Avti, Pramod K., Hegde, Gurumurthy

“…Lemongrass essential oil has antifungal and anti-cancerous properties. Heat-shock protein (HSP90), an ATP-dependent molecular chaperone found in eukaryotes, is…”
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Fabricating Water Dispersible Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications through Ligand Exchange and Direct Conjugation by Lam, Tina, Avti, Pramod K, Pouliot, Philippe, Maafi, Foued, Tardif, Jean-Claude, Rhéaume, Éric, Lesage, Frédéric, Kakkar, Ashok

“…Stable superparamagnetic iron oxide nanoparticles (SPIONs), which can be easily dispersed in an aqueous medium and exhibit high magnetic relaxivities, are…”
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Compromised microvascular oxygen delivery increases brain tissue vulnerability with age by Moeini, Mohammad, Lu, Xuecong, Avti, Pramod K., Damseh, Rafat, Bélanger, Samuel, Picard, Frédéric, Boas, David, Kakkar, Ashok, Lesage, Frédéric

“…Despite the possible role of impaired cerebral tissue oxygenation in age-related cognition decline, much is still unknown about the changes in brain tissue pO…”
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Mechanistic Regulation of Epidermal Growth Factor and Hormonal Receptors by Kinase Inhibitors and Organofluorines in Breast Cancer Therapy by Singh, Jitender, Khanduja, Krishan Lal, Dahiya, Divya, Avti, Pramod K

“…Differential expression patterns of growth factor (EGFR, HER-2) and hormonal (ER, PR) receptors in breast cancer (BC) remain crucial for evaluating and…”
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Designing the 5HT2BR structure and its modulation as a therapeutic target for repurposing approach in drug-resistant epilepsy by Chauhan, Arushi, Singh, Jitender, Sangwan, Namrata, Singh, Harvinder, Prakash, Ajay, Medhi, Bikash, Avti, Pramod K.

“…The study intends to repurpose FDA drugs and investigate the mechanism of (5HT2BR) activation by comprehending inter-residue interactions. The 5HT2BR is a…”
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An Atomic Level Investigation of Sodium Ions Regulating Agonist and Antagonist Binding in the Active Site of a Novel Target 5HT2BR Against Drug-Resistant Epilepsy by Chauhan, Arushi, Singh, Jitender, Sangwan, Namrata, Dhawan, Radhika, Avti, Pramod K.

“…The study investigates the movement of sodium ions inside the ligand-binding pocket of the class-A GPCR serotonin receptor (5HT 2B R), a primary target for…”
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A novel nanoparticle-enhanced photoacoustic stimulus for bone tissue engineering by Sitharaman, Balaji, Avti, Pramod K, Schaefer, Kenneth, Talukdar, Yahfi, Longtin, Jon P

“…In this study, we introduce a novel nanoparticle-enhanced biophysical stimulus based on the photoacoustic (PA) effect. We demonstrate that the PA effect…”
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Integrative network and computational simulation of clinical and genomic data for the identification of mutated EGFR in breast cancer patients for therapeutic targeting using purine analogues by Singh, Jitender, Sangwan, Namrata, Chauhan, Arushi, Avti, Pramod K.

“…EGFR/HER-1, a major oncogene, is frequently activated in breast cancers due to rear mutational events, which reduces the patient's survival rate, hence is a…”
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Integrative Expression, Survival Analysis and Cellular miR-2909 Molecular Interplay in MRN Complex Check Point Sensor Genes (MRN-CSG) Involved in Breast Cancer by Singh, Jitender, Sangwan, Namrata, Chauhan, Arushi, Avti, Pramod K

“…Breast cancer, an emerging global challenge, is evidenced by recent studies of miRNAs involvement in DNA repair gene variants (MRE11, RAD50, and NBN as…”
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Dual functionality of pyrimidine and flavone in targeting genomic variants of EGFR and ER receptors to influence the differential survival rates in breast cancer patients by Avti, Pramod K, Singh, Jitender, Dahiya, Divya, Khanduja, Krishan L

“…Abstract Breast cancer ranks as one of the most prevalent forms of cancer and stands as the primary global cause of mortality among women. Overexpression of…”
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Mechanistic insights into sodium ion-mediated ligand binding affinity and modulation of 5-HT2B GPCR activity: implications for drug discovery and development by Chauhan, Arushi, Singh, Jitender, Sangwan, Namrata, Avti, Pramod K

“…The G-protein coupled receptor (GPCR) family, implicated in neurological disorders and drug targets, includes the sensitive serotonin receptor subtype, 5-HT2B…”
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Screening and identification of phytochemical drug molecules against mutant BRCA1 receptor of breast cancer using computational approaches by Singh, Jitender, Sangwan, Namrata, Chauhan, Arushi, Sarma, Phulen, Prakash, Ajay, Medhi, Bikash, Avti, Pramod K.

“…The American Cancer Society claims that breast cancer is the second most significant cause of cancer-related death, with over one million women diagnosed each…”
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Superparamagnetic iron oxide based nanoprobes for imaging and theranostics by Lam, Tina, Pouliot, Philippe, Avti, Pramod K., Lesage, Frédéric, Kakkar, Ashok K.

“…The need to target, deliver and subsequently evaluate the efficacy of therapeutics in the treatment of a disease has provided added impetus in developing novel…”
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