Search Results - "Avsar, Emin"

Safety and activity of the TGFβ receptor I kinase inhibitor galunisertib plus the anti-PD-L1 antibody durvalumab in metastatic pancreatic cancer by Melisi, Davide, Oh, Do-Youn, Hollebecque, Antoine, Calvo, Emiliano, Varghese, Anna, Borazanci, Erkut, Macarulla, Teresa, Merz, Valeria, Zecchetto, Camilla, Zhao, Yumin, Gueorguieva, Ivelina, Man, Michael, Gandhi, Leena, Estrem, Shawn T, Benhadji, Karim A, Lanasa, Mark C, Avsar, Emin, Guba, Susan C, Garcia-Carbonero, Rocio

“…BackgroundWe assessed the safety, efficacy, and pharmacokinetics of the transforming growth factor beta (TGFβ) receptor inhibitor galunisertib co-administered…”
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A phase Ib/II study of galunisertib in combination with nivolumab in solid tumors and non-small cell lung cancer by Nadal, Ernest, Saleh, Mansoor, Aix, Santiago Ponce, Ochoa-de-Olza, Maria, Patel, Sandip Pravin, Antonia, Scott, Zhao, Yumin, Gueorguieva, Ivelina, Man, Michael, Estrem, Shawn T, Liu, Jiangang, Avsar, Emin, Lin, Wen Hong, Benhadji, Karim A, Gandhi, Leena, Guba, Susan C, Diaz, Inmaculada Ales

“…In this phase Ib/II open-label study, tumor immune suppression was targeted in patients with advanced refractory solid tumors and patients with…”
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Assessment of Segmentation Parameters for Object-Based Land Cover Classification Using Color-Infrared Imagery by Akcay, Ozgun, Avsar, Emin, Inalpulat, Melis, Genc, Levent, Cam, Ahmet

“…Using object-based image analysis (OBIA) techniques for land use-land cover classification (LULC) has become an area of interest due to the availability of…”
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The HSP90 inhibitor NVP-AUY922 potently inhibits non-small cell lung cancer growth by Garon, Edward B, Finn, Richard S, Hamidi, Habib, Dering, Judy, Pitts, Sharon, Kamranpour, Naeimeh, Desai, Amrita J, Hosmer, Wylie, Ide, Susan, Avsar, Emin, Jensen, Michael Rugaard, Quadt, Cornelia, Liu, Manway, Dubinett, Steven M, Slamon, Dennis J

“…Heat shock protein 90 (HSP90) is involved in protein folding and functions as a chaperone for numerous client proteins, many of which are important in…”
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Semantic Segmentation of High-Resolution Airborne Images with Dual-Stream DeepLabV3 by Akcay, Ozgun, Kinaci, Ahmet Cumhur, Avsar, Emin Ozgur, Aydar, Umut

“…In geospatial applications such as urban planning and land use management, automatic detection and classification of earth objects are essential and primary…”
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Trial Outcome and Associative Learning Signals in the Monkey Hippocampus by Wirth, Sylvia, Avsar, Emin, Chiu, Cindy C., Sharma, Varun, Smith, Anne C., Brown, Emery, Suzuki, Wendy A.

“…In tasks of associative learning, animals establish new links between unrelated items by using information about trial outcome to strengthen correct/rewarded…”
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Ganciclovir-resistant cytomegalovirus encephalitis in a hematopoietic stem cell transplant recipient by Arslan, Ferhat, Tabak, Fehmi, Av ar, Emin, Midilli, Kenan, Mert, Ali, Ozaras, Resat, Soysal, Teoman, Ozturk, Recep, Ferhanoglu, Burhan

“…We describe a 41-year-old patient, who upon receiving a bone marrow transplant in order to treat chronic myeloid leukemia, developed cytomegalovirus (CNV)…”
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Comparison of International Prognostic Index and NCCN-IPI in 324 patients with de novo diffuse large B-cell lymphoma: a multi-center retrospective analysis by Öztürk, Erman, Özbalak, Murat, Berk, Selin, Erdoğan, Işıl, Avşar, Emin, Dolgun, Anıl, Çetiner, Mustafa, Mandel, Nil Molinas, Yalnız, Fevzi Fırat, Elverdi, Tuğrul, Salihoğlu, Ayşe, Eşkazan, Ahmet Emre, Ar, Muhlis Cem, Öngören, Şeniz, Başlar, Zafer, Aydın, Yıldız, Soysal, Teoman, Ferhanoğlu, Burhan

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A Phase Ib Dose-Escalation Study of Encorafenib and Cetuximab with or without Alpelisib in Metastatic BRAF -Mutant Colorectal Cancer by van Geel, Robin M J M, Tabernero, Josep, Elez, Elena, Bendell, Johanna C, Spreafico, Anna, Schuler, Martin, Yoshino, Takayuki, Delord, Jean-Pierre, Yamada, Yasuhide, Lolkema, Martijn P, Faris, Jason E, Eskens, Ferry A L M, Sharma, Sunil, Yaeger, Rona, Lenz, Heinz-Josef, Wainberg, Zev A, Avsar, Emin, Chatterjee, Arkendu, Jaeger, Savina, Tan, Eugene, Maharry, Kati, Demuth, Tim, Schellens, Jan H M

“…Preclinical evidence suggests that concomitant BRAF and EGFR inhibition leads to sustained suppression of MAPK signaling and suppressed tumor growth in…”
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A first-in-human phase 1 study of the next-generation RET inhibitor, LOXO-260, in RET inhibitor refractory patients with RET-altered cancers (trial in progress) by Pennell, Nathan A., Wirth, Lori J., Gainor, Justin F., Rotow, Julia K, Johnson, Melissa Lynne, Bauer, Todd Michael, Kroiss, Matthias, Sukrithan, Vineeth, Kang, Hyunseok, Worden, Francis P., Bestvina, Christine M., Hadoux, Julien, Cassier, Philippe Alexandre, Italiano, Antoine, Wolf, Juergen, Brose, Marcia S., Avsar, Emin, Axelson, Michael D., Subbiah, Vivek, Drilon, Alexander E.

“…TPS8595 Background: RET fusions are found in 1-2% of lung adenocarcinomas and 10-20% of papillary thyroid carcinomas. Activating RET mutations occur in 50-60%…”
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First-In-Human Phase I Study of a Next-Generation, Oral, TGFβ Receptor 1 Inhibitor, LY3200882, in Patients with Advanced Cancer by Yap, Timothy A, Vieito, Maria, Baldini, Capucine, Sepúlveda-Sánchez, Juan Manuel, Kondo, Shunsuke, Simonelli, Matteo, Cosman, Rasha, van der Westhuizen, Andre, Atkinson, Victoria, Carpentier, Antoine F, Löhr, Mario, Redman, Rebecca, Mason, Warren, Cervantes, Andres, Le Rhun, Emilie, Ochsenreither, Sebastian, Warren, Louise, Zhao, Yumin, Callies, Sophie, Estrem, Shawn T, Man, Michael, Gandhi, Leena, Avsar, Emin, Melisi, Davide

“…A novel, selective, next-generation transforming growth factor beta (TGFβ) receptor type-1 small molecule inhibitor, LY3200882, demonstrated promising…”
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Abstract CT089: Phase Ib/II of CD40 agonistic antibody APX005M in combination with nivolumab (nivo) in subjects with metastatic melanoma (M) or non-small cell lung cancer (NSCLC) by Kluger, Harriet, Weiss, Sarah A., Olszanski, Anthony J., Schuchter, Lynn, Linette, Gerald P., Garland, Linda, Iannotti, Nicholas O., Johnson, Melissa, Avsar, Emin, Srivastava, Minu K., Trifan, Ovid C., Edelman, Martin J.

“…Abstract Background: Despite recent success with checkpoint inhibitors, the majority of patients with M or NSCLC have a transient response or no response to…”
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Ph1/2 study of Rova-T in combination with nivolumab (Nivo) ± ipilimumab (Ipi) for patients (pts) with 2L+ extensive-stage (ED) SCLC by Malhotra, Jyoti, Nikolinakos, Petros, Leal, Ticiana, Lehman, Jonathan, Morgensztern, Daniel, Patel, Jyoti D., Wrangle, John M., Curigliano, Giuseppe, Dansin, Eric, Greillier, Laurent, Johnson, Melissa Lynne, Ready, Neal, Robinet, Gilles, Lally, Satwant, Wong, Shekman, Avsar, Emin, Valenzuela, Ricardo, Scripture, Charity D., Selvaggi, Giovanni, Besse, Benjamin

“…Abstract only 8516 Background: Rovalpituzumab tesirine (Rova-T™) is an antibody-drug conjugate targeting DLL3, a Notch ligand expressed in SCLC but not normal…”
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FP401EVALUATION OF RELATIONSHIP BETWEEN ANEMIA BODY COMPONENTS, NUTRITIONAL STATUSES AND QUALITY OF LIFE IN PATIENTS WITH CHRONIC KIDNEY DISEASE AT PREDIALYSIS STAGE by Avsar, Emin, Gülçiçek, Sibel, Yalın, Serkan Feyyaz, Alagöz, Selma, Oruç, Meriç, Trabulus, Sinan, Altıparmak, Mehmet Rıza, Seyahi, Nurhan

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Phase 2 results: Encorafenib (ENCO) and cetuximab (CETUX) with or without alpelisib (ALP) in patients with advanced BRAF- mutant colorectal cancer ( BRAFm CRC) by Tabernero, Josep, Geel, Robin Van, Guren, Tormod Kyrre, Yaeger, Rona D., Spreafico, Anna, Faris, Jason Edward, Yoshino, Takayuki, Yamada, Yasuhide, Kim, Tae Won, Bendell, Johanna C., Schuler, Martin H., Lenz, Heinz-Josef, Eskens, Ferry, Desai, Jayesh, Hochster, Howard S., Avsar, Emin, Demuth, Tim, Sandor, Victor, Elez, Elena, Schellens, Jan H.M.

“…Abstract only…”
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Abstract CT136: Final biomarker analysis of the phase I study of the selective BRAF V600 inhibitor encorafenib (LGX818) combined with cetuximab with or without the α-specific PI3K inhibitor alpelisib (BYL719) in patients with advanced BRAF-mutant colorectal cancer by Schellens, Jan H. M., van Geel, Robin, Bendell, Johanna C., Spreafico, Anna, Schuler, Martin, Yoshino, Takayuki, Delord, Jean-Pierre, Yamada, Yasuhide, Lolkema, Martijn P., Faris, Jason E., Eskens, Ferry A. L. M., Sharma, Sunil, Yaeger, Rona, Lenz, Heinz-Josef, Wainberg, Zev A., Avsar, Emin, Chatterjee, Arkendu, Jaeger, Savina, Demuth, Tim, Tabernero, Josep

“…Abstract Background: Although BRAF V600-mutated (BRAFm) colorectal carcinoma (CRC) does not generally respond to BRAF inhibitors, results of preclinical…”
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Adenosine acting via A1 receptors, controls the transition to status epilepticus-like behaviour in an in vitro model of epilepsy by Avsar, Emin, Empson, Ruth M

“…Adenosine has powerful inhibitory effects in the central nervous system. In this study, we aim to understand how adenosine controls the progression of…”
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Phase I study of the selective BRAF V600 inhibitor encorafenib (LGX818) combined with cetuximab and with or without the α-specific PI3K inhibitor BYL719 in patients with advanced BRAF -mutant colorectal cancer by Geel, Robin Van, Elez, Elena, Bendell, Johanna C., Faris, Jason Edward, Lolkema, Martijn P. J. K., Eskens, Ferry, Spreafico, Anna, Kavan, Petr, Delord, Jean-Pierre, Schuler, Martin H., Wainberg, Zev A., Yamada, Yasuhide, Yoshino, Takayuki, Demuth, Tim, Avsar, Emin, Chatterjee, Arkendu, Zhu, Peijuan, Bernards, Rene, Tabernero, Josep, Schellens, Jan HM

“…Abstract only…”
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Phase II study of the HSP90 inhibitor AUY922 in patients with previously treated, advanced non-small cell lung cancer (NSCLC) by Garon, Edward B., Moran, Teresa, Barlesi, Fabrice, Gandhi, Leena, Sequist, Lecia V., Kim, Sang-We, Groen, Harry J.M., Besse, Benjamin, Smit, Egbert F, Kim, Dong-Wan, Akimov, Mikhail, Avsar, Emin, Bailey, Stuart, Felip, Enriqueta

“…Abstract only 7543 Background: AUY922 is a highly potent, non-geldanamycin, HSP90 inhibitor. A Phase I study in advanced solid tumors provided a recommended…”
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Trial Outcome and Associative Learning Signals in the Monkey Hippocampus by Wirth, Sylvia, Avsar, Emin, Chiu, Cindy C, Sharma, Varun, Smith, Anne C, Brown, Emery, Suzuki, Wendy A

“…In tasks of associative learning, animals establish new links between unrelated items by using information about trial outcome to strengthen correct/rewarded…”
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