Search Results - "Avrutsky, Maria I."

Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease by Avrutsky, Maria I., Troy, Carol M.

“…Caspase-9, a cysteine-aspartic protease known for its role as an initiator of intrinsic apoptosis, regulates physiological cell death and pathological tissue…”
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Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion by Avrutsky, Maria I., Ortiz, Crystal Colón, Johnson, Kendra V., Potenski, Anna M., Chen, Claire W., Lawson, Jacqueline M., White, Alexandra J., Yuen, Stephanie K., Morales, Fatima N., Canepa, Elisa, Snipas, Scott, Salvesen, Guy S., Jean, Ying Y., Troy, Carol M.

“…Central nervous system ischemic injury features neuronal dysfunction, inflammation and breakdown of vascular integrity. Here we show that activation of…”
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Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline by Colón Ortiz, Crystal, Neal, Albertine M., Avrutsky, Maria I., Choi, Monica, Smart, Jade, Lawson, Jacqueline, Troy, Carol M.

“…Retinal neurovascular injuries are a leading cause of vision loss in young adults presenting unmet therapeutic needs. Neurovascular injuries damage homeostatic…”
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Caspase-9 inhibition confers stronger neuronal and vascular protection compared to VEGF neutralization in a mouse model of retinal vein occlusion by Avrutsky, Maria I, Chen, Claire W, Lawson, Jacqueline M, Snipas, Scott J, Salvesen, Guy S, Troy, Carol M

“…Retinal vein occlusion (RVO) is a sight-threatening condition typically treated with intravitreal injection of vascular endothelial growth factor (VEGF)…”
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Correction: Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline by Colón Ortiz, Crystal, Neal, Albertine M., Avrutsky, Maria I., Choi, Monica, Smart, Jade, Lawson, Jacqueline, Troy, Carol M.

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Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant by Di Donato, Nataliya, Jean, Ying Y., Maga, A. Murat, Krewson, Briana D., Shupp, Alison B., Avrutsky, Maria I., Roy, Achira, Collins, Sarah, Olds, Carissa, Willert, Rebecca A., Czaja, Agnieszka M., Johnson, Rachel, Stover, Jessi A., Gottlieb, Steven, Bartholdi, Deborah, Rauch, Anita, Goldstein, Amy, Boyd-Kyle, Victoria, Aldinger, Kimberly A., Mirzaa, Ghayda M., Nissen, Anke, Brigatti, Karlla W., Puffenberger, Erik G., Millen, Kathleen J., Strauss, Kevin A., Dobyns, William B., Troy, Carol M., Jinks, Robert N.

“…Lissencephaly is a malformation of cortical development typically caused by deficient neuronal migration resulting in cortical thickening and reduced gyration…”
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A cross‐sectional study comparing the inflammatory profile of menstrual effluent vs. peripheral blood by Naseri, Sara, Rosenberg‐Hasson, Yael, Maecker, Holden T., Avrutsky, Maria I., Blumenthal, Paul D.

“…Background and Aims Cytokine profiles of peripheral blood and other bodily fluids provide diagnostic indicators for assessing inflammatory processes. Menstrual…”
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Author Correction: Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion by Avrutsky, Maria I., Ortiz, Crystal Colón, Johnson, Kendra V., Potenski, Anna M., Chen, Claire W., Lawson, Jacqueline M., White, Alexandra J., Yuen, Stephanie K., Morales, Fatima N., Canepa, Elisa, Snipas, Scott, Salvesen, Guy S., Jean, Ying Y., Troy, Carol M.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Independent chromatin binding of ARGONAUTE4 and SPT5L/KTF1 mediates transcriptional gene silencing by Rowley, M Jordan, Avrutsky, Maria I, Sifuentes, Christopher J, Pereira, Ligia, Wierzbicki, Andrzej T

“…Eukaryotic genomes contain significant amounts of transposons and repetitive DNA elements, which, if transcribed, can be detrimental to the organism…”
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Concordance of hemoglobin A1c and reproductive hormone levels in menstrual and venous blood by Naseri, Sara, Avrutsky, Maria I., Capati, Carlo, Desai, Khevna, Alvero, Ruben, Blumenthal, Paul D.

“…To explore whether menstrual blood collected via a modified menstrual pad is a surrogate for venous blood drawn in analyzing hemoglobin A1c (HbA1c) and…”
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In vivo Vascular Injury Readouts in Mouse Retina to Promote Reproducibility by Chen, Claire W, Potenski, Anna M, Colón Ortiz, Crystal K, Avrutsky, Maria I, Troy, Carol M

“…Advancements in ophthalmic imaging tools offer an unprecedented level of access to researchers working with animal models of neurovascular injury. To properly…”
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Noninvasive Ophthalmic Imaging Measures Retinal Degeneration and Vision Deficits in Ndufs4 −/− Mouse Model of Mitochondrial Complex I Deficiency by Avrutsky, Maria I., Lawson, Jacqueline M., Smart, Jade E., Chen, Claire W., Troy, Carol M.

“…PurposeTo characterize postnatal ocular pathology in a Ndufs4-/- mouse model of complex I deficiency using noninvasive retinal imaging and visual testing…”
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Endothelial Caspase-9 Activity Exacerbates Edema and Neuronal Dysfunction after Retinal Vein Occlusion by Avrutsky, Maria I

“…The retina is one of the most metabolically active tissue in the body, rendering it sensitive to vascular dysfunction. Consequently, diseases that disrupt…”
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Independent Chromatin Binding of ARGONAUTE4 and SPT5L/KTF1 Mediates Transcriptional Gene Silencing: e1002120 by Rowley, M Jordan, Avrutsky, Maria I, Sifuentes, Christopher J, Pereira, Ligia, Wierzbicki, Andrzej T

“…Eukaryotic genomes contain significant amounts of transposons and repetitive DNA elements, which, if transcribed, can be detrimental to the organism…”
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