Search Results - "Avrova, N F"

The Effect of Intranasal Administration of Gangliosides on the Viability of CA1 Hippocampal Neurons in Rat Two-Vessel Occlusion Model of Forebrain Ischemia/Reperfusion Injury by Avrova, D. K., Bayunova, L. V., Avrova, N. F., Zakharova, I. O.

“…Intranasal administration of total bovine brain gangliosides (6 mg/kg) to rats protected the CA1 hippocampal neurons from the death caused by two-vessel…”
Get full text

Brain Gangliosides and Their Functions as Natural Adaptogens by Avrova, N. F.

“…This review uses gangliosides as an example to characterize various aspects of studies of vertebrate brain lipids directed by Academician E. M. Kreps and…”
Get full text

Neuroprotective Effect of Insulin on Rat Cortical Neurons in Oxidative Stress Is Mediated by Autophagy and Apoptosis Inhibition in vitro by Zakharova, I. O., Bayunova, L. V., Avrova, D. K., Avrova, N. F.

“…Although insulin is one of the most promising neuroprotectors, it is still unknown whether it is able to prevent autophagic neuronal cell death. In this work,…”
Get full text

Intranasal Insulin Administration to Rats with Forebrain Ischemia and Reperfusion Injury Reduces Autophagy and Apoptosis Intensity in the Hippocampus and Frontal Cortex, a Possible Mechanism of Action by Zakharova, I. O., Bayunova, L. V., Avrova, D. K., Avrova, N. F.

“…Rat forebrain ischemia followed by a 3-day reperfusion led to an increase in the levels of the autophagic marker LC3B-II and glial fibrillary acidic protein…”
Get full text

Intranasal Insulin and Gangliosides Correct Cognitive Impairments and Signaling Pathways in the Hippocampus of Rats with Type 2 Diabetes Mellitus by Zakharova, I. O., Bayunova, L. V., Derkach, K. V., Shpakov, A. O., Avrova, N. F.

“…Insulin controls both systemic glucose homeostasis and functional brain activity. In type 2 diabetes mellitus (DM2), insulin content and the activity of the…”
Get full text

Intranasal Insulin Decreases Autophagic and Apoptotic Death of Neurons in the Rat Hippocampal C1 Region and Frontal Cortex under Forebrain Ischemia–Reperfusion by Fokina, E. A., Zakharova, I. O., Bayunova, L. V., Avrova, D. K., Ilyasov, I. O., Avrova, N. F.

“…The development of approaches to therapy of ischemic brain injuries requires a better insight into the mechanisms that regulate both apoptotic and autophagic…”
Get full text

Protective and Antioxidant Effects of Insulin on Rat Brain Cortical Neurons in an in vitro Model of Oxygen and Glucose Deprivation by Zakharova, I. O., Zorina, I. I., Bayunova, L. V., Shpakov, A. O., Avrova, N. F.

“…Insulin is one of the most promising protectors in the treatment of neurodegenerative and other diseases associated with brain injuries. In these diseases,…”
Get full text

Effects of Intranasally Administered Insulin and Gangliosides on Metabolic Parameters and Activity of the Hepatic Insulin System in Rats with Type 2 Diabetes Mellitus by Zakharova, I. O., Bayunova, L. V., Derkach, K. V., Ilyasov, I. O., Shpakov, A. O., Avrova, N. F.

“…Insulin regulates glucose metabolism via both direct hormone interactions with its signaling system and glucose transporters in cells of peripheral tissues and…”
Get full text

Insulin and Brain Gangliosides Prevent Metabolic Disorders Caused by Activation of Free Radical Reactions after Two-Vessel Ischemia–Reperfusion Injury to the Rat Forebrain by Zakharova, I. O., Bayunova, L. V., Zorina, I. I., Shpakov, A. O., Avrova, N. F.

“…The ability of insulin and gangliosides, administered separately or jointly, to increase the viability of cultured brain cortical neurons under conditions of…”
Get full text

Phagocytic Activity of Rat Primary Astrocytes Is Regulated by Insulin and Ganglioside GM1 by Sokolova, T. V., Rychkova, M. P., Basova, N. E., Vasilev, D. S., Avrova, N. F., Yefimova, M. G.

“…A timely and efficient removal of apoptotic cells and their fragments is essential to maintain tissue homeostasis in normal and pathological conditions. Since…”
Get full text

Intranasal Administration of Insulin and Gangliosides Improves Spatial Memory in Rats with Neonatal Type 2 Diabetes Mellitus by Sukhov, I. B., Lebedeva, M. F., Zakharova, I. O., Derkach, K. V., Bayunova, L. V., Zorina, I. I., Avrova, N. F., Shpakov, A. O.

“…We analyzed the effects of intranasal administration of insulin (0.48 U/rat) and gangliosides (6 mg/kg) on spatial memory in rats with the neonatal model of…”
Get full text

Effects of Intranasally Administered Insulin and Gangliosides on Hypothalamic Signaling and Expression of Hepatic Gluconeogenesis Genes in Rats with Type 2 Diabetes Mellitus by Zakharova, I. O., Bayunova, L. V., Derkach, K. V., Ilyasov, I. O., Morina, I. Yu, Shpakov, A. O., Avrova, N. F.

“…The insulin signaling system in hypothalamic neurons plays an important role in the central regulation of glucose metabolism, feeding behavior, and tissue…”
Get full text

Insulin Administration Prevents Accumulation of Conjugated Dienes and Trienes and Inactivation of Na+, K+-ATPase in the Rat Cerebral Cortex during Two-Vessel Forebrain Ischemia and Reperfusion by Zorina, I. I., Zakharova, I. O., Bayunova, L. V., Avrova, N. F.

Get full text

Inhibition of glutamate-induced intensification of free radical reactions by gangliosides : Possible role in their protective effect in rat cerebellar granule cells and brain synaptosomes by AVROVA, N. F, VICTOROV, I. V, TYURIN, V. A, ZAKHAROVA, I. O, SOKOLOVA, T. V, ANDREEVA, N. A, STELMASCHUK, E. V, TYURINA, Y. Y, GONCHAR, V. S

“…The neurotoxic effect of exposure of rat cerebellar granule cells to glutamate (100 microM) is to a large extent prevented by incubation of neurons not only…”
Get full text

Erratum to: Phagocytic Activity of Rat Primary Astrocytes Is Regulated by Insulin and Ganglioside GM1 by Sokolova, T. V., Rychkova, M. P., Basova, N. E., Vasilev, D. S., Avrova, N. F., Yefimova, M. G.

Get full text

Phagocytosis of Apoptotic Substrates Is Accompanied by Proliferation of Cultured Rat Primary Astrocytes by Sokolova, T. V., Vasilyev, D. S., Rychkova, M. P., Avrova, N. F., Yefimova, M. G.

Get full text

Insulin Increases Viability of Neurons in Rat Cerebral Cortex and Normalizes Bax/Bcl-2 Ratio under Conditions of Oxidative Stress by Bayunova, L. V., Zorina, I. I., Zakharova, I. O., Avrova, N. F.

“…We studied the protective effect of insulin in various concentrations and its effect on the Bax/ Bcl-2 ratio in neurons of rat cerebral cortex under conditions…”
Get full text

Gangliosides GM1 and GD1a normalize respiratory rates of rat brain mitochondria reduced by tert-butyl hydroperoxide by Korotkov, S. M., Sokolova, T. V., Avrova, N. F.

“…The rate of oxygen consumption by glutamate- and malate-energized rat brain mitochondria, which was stimulated by an uncoupler 2,4-dinitrophenol (DNP),…”
Get full text

Role of tyrosine kinase of Trk-Receptors in realization of antioxidant effect of ganglioside GM1 in PC12 cells by Vlasova, Yu. A, Zakharova, I. O, Sokolova, T. I, Furaev, V. V, Rychkova, M. P, Avrova, N. F

“…Ganglioside GM1 has been shown to increase viability of PC12 cells at their induction of oxidative stress by hydrogen peroxide. However, in the presence of…”
Get full text

Protective Effect of Insulin on Rat Cortical Neurons in Oxidative Stress and Its Dependence on Modulation of Protein Kinase B (Akt) Activity by Zakharova, I. O., Sokolova, T. V., Zorina, I. I., Bayunova, L. V., Rychkova, M. P., Avrova, N. F.

“…Clinical trials of insulin and experiments on its intranasal administration to animals suggest that this hormone can be efficient in treating human…”
Get full text