Search Results - "Avolio, Elisa"

Cardiac pericyte reprogramming by MEK inhibition promotes arteriologenesis and angiogenesis of the ischemic heart by Avolio, Elisa, Katare, Rajesh, Thomas, Anita C, Caporali, Andrea, Schwenke, Daryl, Carrabba, Michele, Meloni, Marco, Caputo, Massimo, Madeddu, Paolo

“…Pericytes (PCs) are abundant yet remain the most enigmatic and ill-defined cell population in the heart. Here, we investigated whether PCs can be reprogrammed…”
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Perivascular cells and tissue engineering: Current applications and untapped potential by Avolio, Elisa, Alvino, Valeria V, Ghorbel, Mohamed T, Campagnolo, Paola

“…The recent development of tissue engineering provides exciting new perspectives for the replacement of failing organs and the repair of damaged tissues…”
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Transplantation of Human Pericyte Progenitor Cells Improves the Repair of Infarcted Heart Through Activation of an Angiogenic Program Involving Micro-RNA-132 by Katare, Rajesh, Riu, Federica, Mitchell, Kathryn, Gubernator, Miriam, Campagnolo, Paola, Cui, Yuxin, Fortunato, Orazio, Avolio, Elisa, Cesselli, Daniela, Beltrami, Antonio Paolo, Angelini, Gianni, Emanueli, Costanza, Madeddu, Paolo

“…RATIONALE:Pericytes are key regulators of vascular maturation, but their value for cardiac repair remains unknown. OBJECTIVE:We investigated the therapeutic…”
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Combined Intramyocardial Delivery of Human Pericytes and Cardiac Stem Cells Additively Improves the Healing of Mouse Infarcted Hearts Through Stimulation of Vascular and Muscular Repair by Avolio, Elisa, Meloni, Marco, Spencer, Helen L, Riu, Federica, Katare, Rajesh, Mangialardi, Giuseppe, Oikawa, Atsuhiko, Rodriguez-Arabaolaza, Iker, Dang, Zexu, Mitchell, Kathryn, Reni, Carlotta, Alvino, Valeria V, Rowlinson, Jonathan, Livi, Ugolini, Cesselli, Daniela, Angelini, Gianni, Emanueli, Costanza, Beltrami, Antonio P, Madeddu, Paolo

“…RATIONALE:Optimization of cell therapy for cardiac repair may require the association of different cell populations with complementary activities…”
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Author Correction: The adipokine leptin modulates adventitial pericyte functions by autocrine and paracrine signalling by Riu, Federica, Slater, Sadie C., Garcia, Eva Jover, Rodriguez-Arabaolaza, Iker, Alvino, Valeria, Avolio, Elisa, Mangialardi, Giuseppe, Cordaro, Andrea, Satchell, Simon, Zebele, Carlo, Caporali, Andrea, Angelini, Gianni, Madeddu, Paolo

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MEK inhibitors: a promising targeted therapy for cardiovascular disease by Mohammed, Khaled A K, Madeddu, Paolo, Avolio, Elisa

“…Cardiovascular disease (CVD) represents the leading cause of mortality and disability all over the world. Identifying new targeted therapeutic approaches has…”
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The tyrosine kinase inhibitor Dasatinib reduces cardiac steatosis and fibrosis in obese, type 2 diabetic mice by Gu, Yue, Avolio, Elisa, Alvino, Valeria V, Thomas, Anita C, Herman, Andrew, Miller, Poppy J, Sullivan, Niall, Faulkner, Ashton, Madeddu, Paolo

“…Cardiac steatosis is an early yet overlooked feature of diabetic cardiomyopathy. There is no available therapy to treat this condition. Tyrosine kinase…”
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Role for Substance P―Based Nociceptive Signaling in Progenitor Cell Activation and Angiogenesis During Ischemia in Mice and in Human Subjects by AMADESI, Silvia, RENI, Carlotta, ASCIONE, Raimondo, CANGIANO, Elisa, VALGIMIGLI, Marco, HUNT, Stephen P, EMANUELI, Costanza, MADEDDU, Paolo, KATARE, Rajesh, MELONI, Marco, OIKAWA, Atsuhiko, BELTRAMI, Antonio P, AVOLIO, Elisa, CESSELLI, Daniela, FORTUNATO, Orazio, SPINETTI, Gaia

“…Pain triggers a homeostatic alarm reaction to injury. It remains unknown, however, whether nociceptive signaling activated by ischemia is relevant for…”
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Ex Vivo Molecular Rejuvenation Improves the Therapeutic Activity of Senescent Human Cardiac Stem Cells in a Mouse Model of Myocardial Infarction by Avolio, Elisa, Gianfranceschi, Giuseppe, Cesselli, Daniela, Caragnano, Angela, Athanasakis, Emmanouil, Katare, Rajesh, Meloni, Marco, Palma, Anita, Barchiesi, Arianna, Vascotto, Carlo, Toffoletto, Barbara, Mazzega, Elisa, Finato, Nicoletta, Aresu, Giuseppe, Livi, Ugolino, Emanueli, Costanza, Scoles, Giacinto, Beltrami, Carlo Alberto, Madeddu, Paolo, Beltrami, Antonio Paolo

“…Cardiac stem cells (CSC) from explanted decompensated hearts (E‐CSC) are, with respect to those obtained from healthy donors (D‐CSC), senescent and…”
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Boosting the pentose phosphate pathway restores cardiac progenitor cell availability in diabetes by Katare, Rajesh, Oikawa, Atsuhiko, Cesselli, Daniela, Beltrami, Antonio P, Avolio, Elisa, Muthukrishnan, Deepti, Munasinghe, Pujika Emani, Angelini, Gianni, Emanueli, Costanza, Madeddu, Paolo

“…Diabetes impinges upon mechanisms of cardiovascular repair. However, the biochemical adaptation of cardiac stem cells to sustained hyperglycaemia remains…”
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BPIFB4 and its longevity-associated haplotype protect from cardiac ischemia in humans and mice by Cattaneo, Monica, Aleksova, Aneta, Malovini, Alberto, Avolio, Elisa, Thomas, Anita, Alvino, Valeria Vincenza, Kilcooley, Michael, Pieronne-Deperrois, Marie, Ouvrard-Pascaud, Antoine, Maciag, Anna, Spinetti, Gaia, Kussauer, Sophie, Lemcke, Heiko, Skorska, Anna, Vasudevan, Praveen, Castiglione, Stefania, Raucci, Angela, David, Robert, Richard, Vincent, Beltrami, Antonio Paolo, Madeddu, Paolo, Puca, Annibale Alessandro

“…Long-living individuals (LLIs) escape age-related cardiovascular complications until the very last stage of life. Previous studies have shown that a…”
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In Vitro and In Vivo Preclinical Testing of Pericyte-Engineered Grafts for the Correction of Congenital Heart Defects by Alvino, Valeria Vincenza, Kilcooley, Michael, Thomas, Anita C, Carrabba, Michele, Fagnano, Marco, Cathery, William, Avolio, Elisa, Iacobazzi, Dominga, Ghorbel, Mohamed, Caputo, Massimo, Madeddu, Paolo

“…Background We have previously reported the possibility of using pericytes from leftovers of palliative surgery of congenital heart disease to engineer…”
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The adipokine leptin modulates adventitial pericyte functions by autocrine and paracrine signalling by Riu, Federica, Slater, Sadie C., Garcia, Eva Jover, Rodriguez-Arabaolaza, Iker, Alvino, Valeria, Avolio, Elisa, Mangialardi, Giuseppe, Cordaro, Andrea, Satchell, Simon, Zebele, Carlo, Caporali, Andrea, Angelini, Gianni, Madeddu, Paolo

“…Transplantation of adventitial pericytes (APCs) improves recovery from tissue ischemia in preclinical animal models by still unknown mechanisms. This study…”
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Transplantation of Allogeneic Pericytes Improves Myocardial Vascularization and Reduces Interstitial Fibrosis in a Swine Model of Reperfused Acute Myocardial Infarction by Alvino, Valeria Vincenza, Fernández‐Jiménez, Rodrigo, Rodriguez‐Arabaolaza, Iker, Slater, Sadie, Mangialardi, Giuseppe, Avolio, Elisa, Spencer, Helen, Culliford, Lucy, Hassan, Sakinah, Sueiro Ballesteros, Lorena, Herman, Andrew, Ayaon‐Albarrán, Ali, Galán‐Arriola, Carlos, Sánchez‐González, Javier, Hennessey, Helena, Delmege, Catherine, Ascione, Raimondo, Emanueli, Costanza, Angelini, Gianni Davide, Ibanez, Borja, Madeddu, Paolo

“…Background Transplantation of adventitial pericytes (APCs) promotes cardiac repair in murine models of myocardial infarction. The aim of present study was to…”
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Murine studies and expressional analyses of human cardiac pericytes reveal novel trajectories of SARS-CoV-2 Spike protein-induced microvascular damage by Avolio, Elisa, Srivastava, Prashant K., Ji, Jiahui, Carrabba, Michele, Tsang, Christopher T. W., Gu, Yue, Thomas, Anita C., Gupta, Kapil, Berger, Imre, Emanueli, Costanza, Madeddu, Paolo

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Umbilical Cord Pericytes Provide a Viable Alternative to Mesenchymal Stem Cells for Neonatal Vascular Engineering by Cathery, William, Faulkner, Ashton, Jover, Eva, Rodriguez-Arabaolaza, Iker, Thomas, Anita C, Avolio, Elisa, Caputo, Massimo, Madeddu, Paolo

“…Reconstructive surgery of congenital heart disease (CHD) remains inadequate due to the inability of prosthetic grafts to match the somatic growth of pediatric…”
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Fabrication of New Hybrid Scaffolds for in vivo Perivascular Application to Treat Limb Ischemia by Carrabba, Michele, Jover, Eva, Fagnano, Marco, Thomas, Anita C, Avolio, Elisa, Richardson, Thomas, Carter, Ben, Vozzi, Giovanni, Perriman, Adam W, Madeddu, Paolo

“…Cell therapies are emerging as a new therapeutic frontier for the treatment of ischemic disease. However, femoral occlusions can be challenging environments…”
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Personalized Cardiovascular Regenerative Medicine: Targeting the Extreme Stages of Life by Madeddu, Paolo, Avolio, Elisa, Alvino, Valeria Vincenza, Santopaolo, Marianna, Spinetti, Gaia

“…Cardiovascular regenerative medicine is an exciting new approach that promises to change the current care of million people world-wide. Major emphasis was…”
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Reconstruction of the Swine Pulmonary Artery Using a Graft Engineered With Syngeneic Cardiac Pericytes by Alvino, Valeria Vincenza, Thomas, Anita C, Ghorbel, Mohamed T, Rapetto, Filippo, Narayan, Srinivas A, Kilcooley, Michael, Iacobazzi, Dominga, Carrabba, Michele, Fagnano, Marco, Cathery, William, Avolio, Elisa, Caputo, Massimo, Madeddu, Paolo

“…The neonatal heart represents an attractive source of regenerative cells. Here, we report the results of a randomized, controlled, investigator-blinded…”
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Multi-Omics Analysis of Diabetic Heart Disease in the db/db Model Reveals Potential Targets for Treatment by a Longevity-Associated Gene by Faulkner, Ashton, Dang, Zexu, Avolio, Elisa, Thomas, Anita C, Batstone, Thomas, Lloyd, Gavin R, Weber, Ralf Jm, Najdekr, Lukáš, Jankevics, Andris, Dunn, Warwick B, Spinetti, Gaia, Vecchione, Carmine, Puca, Annibale A, Madeddu, Paolo

“…Characterisation of animal models of diabetic cardiomyopathy may help unravel new molecular targets for therapy. Long-living individuals are protected from the…”
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