Search Results - "Avlani, Vimesh"

Allosteric Modulation of the Calcium-sensing Receptor by γ-Glutamyl Peptides: INHIBITION OF PTH SECRETION, SUPPRESSION OF INTRACELLULAR cAMP LEVELS, AND A COMMON MECHANISM OF ACTION WITH L-AMINO ACIDS by Broadhead, Geoffrey K, Mun, Hee-chang, Avlani, Vimesh A, Jourdon, Orane, Church, W. Bret, Christopoulos, Arthur, Delbridge, Leigh, Conigrave, Arthur D

“…γ-Glutamyl peptides were identified previously as novel positive allosteric modulators of Ca²⁺o-dependent intracellular Ca²⁺ mobilization in HEK-293 cells that…”
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Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands by Avlani, Vimesh A., Gregory, Karen J., Morton, Craig J., Parker, Michael W., Sexton, Patrick M., Christopoulos, Arthur

“…The second extracellular (E2) loop of G protein-coupled receptors (GPCRs) plays an essential but poorly understood role in the binding of non-peptidic small…”
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Calcium-sensing receptor-dependent activation of CREB phosphorylation in HEK293 cells and human parathyroid cells by Avlani, Vimesh A, Ma, Wenting, Mun, Hee-Chang, Leach, Katie, Delbridge, Leigh, Christopoulos, Arthur, Conigrave, Arthur D

“…In addition to its acute effects on hormone secretion, epithelial transport, and shape change, the calcium-sensing receptor (CaSR) modulates the expression of…”
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Roles of intraloops-2 and -3 and the proximal C-terminus in signalling pathway selection from the human calcium-sensing receptor by Goolam, Mahvash A., Ward, James H., Avlani, Vimesh A., Leach, Katie, Christopoulos, Arthur, Conigrave, Arthur D.

“…•Intracellular loops-2 (iL-2) and -3 (iL-3) and the proximal C-terminus support Ca2+o-stimulated signalling.•The proximal C-terminus is not required for…”
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Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors by May, Lauren T, Avlani, Vimesh A, Langmead, Christopher J, Herdon, Hugh J, Wood, Martyn D, Sexton, Patrick M, Christopoulos, Arthur

“…The M2 muscarinic acetylcholine receptor (mAChR) possesses at least one binding site for allosteric modulators that is dependent on the residues…”
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Orthosteric and allosteric modes of interaction of novel selective agonists of the M1 muscarinic acetylcholine receptor by Avlani, Vimesh A, Langmead, Christopher J, Guida, Elizabeth, Wood, Martyn D, Tehan, Ben G, Herdon, Hugh J, Watson, Jeannette M, Sexton, Patrick M, Christopoulos, Arthur

“…Recent years have witnessed the discovery of novel selective agonists of the M(1) muscarinic acetylcholine (ACh) receptor (mAChR). One mechanism invoked to…”
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The impact of orthosteric radioligand depletion on the quantification of allosteric modulator interactions by Avlani, Vimesh A, McLoughlin, David J, Sexton, Patrick M, Christopoulos, Arthur

“…Radioligand binding assays remain a common method for quantifying the effects of allosteric modulators at G protein-coupled receptors. The allosteric ternary…”
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Application of a kinetic model to the apparently complex behavior of negative and positive allosteric modulators of muscarinic acetylcholine receptors by Avlani, Vimesh, May, Lauren T, Sexton, Patrick M, Christopoulos, Arthur

“…The binding of allosteric modulators to G protein-coupled receptors (GPCRs) is often described by an equilibrium allosteric ternary complex model (ATCM). This…”
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Allosteric Modulation of the Calcium-sensing Receptor by γ-Glutamyl Peptides by Broadhead, Geoffrey K., Mun, Hee-chang, Avlani, Vimesh A., Jourdon, Orane, Church, W. Bret, Christopoulos, Arthur, Delbridge, Leigh, Conigrave, Arthur D.

“…γ-Glutamyl peptides were identified previously as novel positive allosteric modulators of Ca2+o-dependent intracellular Ca2+ mobilization in HEK-293 cells that…”
Get full text

Allosteric Modulation of the Calcium-sensing Receptor by γ-Glutamyl Peptides: INHIBITION OF PTH SECRETION, SUPPRESSION OF INTRACELLULAR cAMP LEVELS, AND A COMMON MECHANISM OF ACTION WITH by Broadhead, Geoffrey K., Mun, Hee-chang, Avlani, Vimesh A., Jourdon, Orane, Church, W. Bret, Christopoulos, Arthur, Delbridge, Leigh, Conigrave, Arthur D.

“…γ-Glutamyl peptides were identified previously as novel positive allosteric modulators of Ca 2+ o -dependent intracellular Ca 2+ mobilization in HEK-293 cells…”
Get full text