Search Results - "Avitabile, Concetta"
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An anti-PDGFRβ aptamer for selective delivery of small therapeutic peptide to cardiac cells
Published in PloS one (2018)“…Small therapeutic peptides represent a promising field for the treatment of pathologies such as cardiac diseases. However, the lack of proper target-selective…”
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Combination of the Systemin peptide with the beneficial fungus Trichoderma afroharzianum T22 improves plant defense responses against pests and diseases
Published in Journal of plant interactions (31-12-2022)“…Trichoderma spp. are among the most widely used plant beneficial fungi in agriculture. Its interaction with the plant triggers resistance responses by the…”
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Design, structural and functional characterization of a Temporin-1b analog active against Gram-negative bacteria
Published in Biochimica et biophysica acta (01-06-2013)“…Temporins are small antimicrobial peptides secreted by the Rana temporaria showing mainly activity against Gram-positive bacteria. However, different members…”
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γ Sulphate PNA (PNA S): highly selective DNA binding molecule showing promising antigene activity
Published in PloS one (07-05-2012)“…Peptide Nucleic Acids (PNAs), nucleic acid analogues showing high stability to enzyme degradation and strong affinity and specificity of binding toward DNA and…”
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Label-free DNA biosensing by topological light confinement
Published in Nanophotonics (Berlin, Germany) (01-12-2021)“…Large-area and transparent all-dielectric metasurfaces sustaining photonic bound states in the continuum (BICs) provide a set of fundamental advantages for…”
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Colonization of Solanum melongena and Vitis vinifera Plants by Botrytis cinerea Is Strongly Reduced by the Exogenous Application of Tomato Systemin
Published in Journal of fungi (Basel) (29-12-2020)“…Plant defense peptides are able to control immune barriers and represent a potential novel resource for crop protection. One of the best-characterized plant…”
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Tomato Plants Treated with Systemin Peptide Show Enhanced Levels of Direct and Indirect Defense Associated with Increased Expression of Defense-Related Genes
Published in Plants (Basel) (03-10-2019)“…Plant defense peptides represent an important class of compounds active against pathogens and insects. These molecules controlling immune barriers can…”
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Liquid Biopsy beyond Cancer: A miRNA Detection in Serum with Electrochemical Chip for Non‐Invasive Coeliac Disease Diagnosis
Published in Advanced NanoBiomed Research (Online) (01-09-2022)“…Coeliac disease is a very common autoimmune disease estimated to affect 1 in 100 people worldwide. It occurs in genetically predisposed people where the…”
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New perspectives for natural antimicrobial peptides: application as antinflammatory drugs in a murine model
Published in BMC immunology (17-11-2012)“…Antimicrobial peptides (AMPs) are an ancient group of defense molecules. AMPs are widely distributed in nature (being present in mammals, birds, amphibians,…”
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Circular Dichroism studies on the interactions of antimicrobial peptides with bacterial cells
Published in Scientific reports (12-03-2014)“…Studying how antimicrobial peptides interact with bacterial cells is pivotal to understand their mechanism of action. In this paper we explored the use of…”
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Paper-based electrochemical peptide nucleic acid (PNA) biosensor for detection of miRNA-492: a pancreatic ductal adenocarcinoma biomarker
Published in Biosensors & bioelectronics (01-10-2020)“…Pancreatic ductal adenocarcinoma is the predominant neoplastic disease of the pancreas and it represents the fourth most frequent cause of death in…”
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Targeting pre-miRNA by peptide nucleic acids: a new strategy to interfere in the miRNA maturation
Published in Artificial DNA, PNA & XNA (01-04-2012)“…PNAs conjugated to carrier peptides have been employed for the targeting of miRNA precursor, with the aim to develop molecules able to interfere in the…”
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Paper-based electrochemical peptide sensor for on-site detection of botulinum neurotoxin serotype A and C
Published in Biosensors & bioelectronics (01-07-2021)“…Botulinum neurotoxins (BoNTs) produced by soil bacterium Clostridium botulinum are cause of botulism and listed as biohazard agents, thus rapid screening…”
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The antimicrobial peptide Temporin L impairs E. coli cell division by interacting with FtsZ and the divisome complex
Published in Biochimica et biophysica acta. General subjects (01-07-2020)“…The comprehension of the mechanism of action of antimicrobial peptides is fundamental for the design of new antibiotics. Studies performed looking at the…”
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Diphenylalanine Motif Drives Self‐Assembling in Hybrid PNA‐Peptide Conjugates
Published in Chemistry : a European journal (13-10-2021)“…Peptides and nucleic acids can self‐assemble to give supramolecular structures that find application in different fields, ranging from the delivery of drugs to…”
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Effects of decoy molecules targeting NF-kappaB transcription factors in Cystic fibrosis IB3-1 cells: recruitment of NF-kappaB to the IL-8 gene promoter and transcription of the IL-8 gene
Published in Artificial DNA, PNA & XNA (01-04-2012)“…One of the clinical features of cystic fibrosis (CF) is a deep inflammatory process, which is characterized by production and release of cytokines and…”
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Fluorescence and Morphology of Self‐Assembled Nucleobases and Their Diphenylalanine Hybrid Aggregates
Published in Chemistry : a European journal (22-11-2019)“…Studies carried out in recent decades have revealed that the ability to self‐assemble is a widespread property among biomolecules. Small nucleic acid moieties…”
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Non-covalent strategies to functionalize polymeric nanoparticles with NGR peptides for targeting breast cancer
Published in International journal of pharmaceutics (25-02-2023)“…[Display omitted] •Polymeric NPs functionalized with NGR peptides to target breast cancer are developed.•Targeting peptides are anchored on NP surface through…”
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Oligonucleotide Analogues as Modulators of the Expression and Function of Noncoding RNAs (ncRNAs): Emerging Therapeutics Applications
Published in Journal of medicinal chemistry (26-12-2014)“…ncRNAs are emerging as key regulators of physiological and pathological processes and therefore have been identified as pharmacological targets and as markers…”
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