Search Results - "Aviño, Anna"

Site-directed cysteine coupling of disulfide-containing non-antibody carrier proteins (THIOCAPs) by Rueda, Ariana, Mendoza, Julian I., Alba-Castellon, Lorena, Parladé, Eloi, Voltà-Durán, Eric, Paez, David, Aviño, Anna, Eritja, Ramon, Vázquez, Esther, Villaverde, Antonio, Mangues, Ramón, Unzueta, Ugutz

“…The development of a new generation of non-antibody protein drug delivery systems requires site-directed conjugation strategies to produce homogeneous,…”
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Chemical Modifications in Nucleic Acids for Therapeutic and Diagnostic Applications by Fàbrega, Carme, Aviñó, Anna, Eritja, Ramon

“…The last decade has witnessed the blooming of nucleic acids for therapeutic and diagnostic applications. In the present article, we describe the most important…”
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Controlling the Reversible Assembly of Liposomes through a Multistimuli Responsive Anchored DNA by Hernández-Ainsa, Silvia, Ricci, Maria, Hilton, Lloyd, Aviñó, Anna, Eritja, Ramon, Keyser, Ulrich F

“…We present a novel approach to reversibly control the assembly of liposomes through an anchored multistimuli responsive DNA oligonucleotide decorated with an…”
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Oligonucleotides Carrying Nucleoside Antimetabolites as Potential Prodrugs by Fàbrega, Carme, Clua, Anna, Eritja, Ramon, Aviñó, Anna

“…Nucleoside and nucleobase antimetabolites are an important class of chemotherapeutic agents for the treatment of cancer as well as other diseases. In order to…”
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Quadruplex-duplex junction in LTR-III: A molecular insight into the complexes with BMH-21, namitecan and doxorubicin by Mazzini, Stefania, Borgonovo, Gigliola, Princiotto, Salvatore, Artali, Roberto, Musso, Loana, Aviñó, Anna, Eritja, Ramon, Gargallo, Raimundo, Dallavalle, Sabrina

“…Quadruplex-Duplex (Q-D) junctions are unique structural motifs garnering increasing interest as drug targets, due to their frequent occurrence in genomic…”
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Thrombin binding aptamer, more than a simple aptamer: chemically modified derivatives and biomedical applications by Avino, Anna, Fabrega, Carme, Tintore, Maria, Eritja, Ramon

“…The thrombin binding aptamer (TBA) is a well characterized chair-like, antiparallel quadruplex structure that binds specifically to thrombin at nanomolar…”
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G-quadruplex binding properties of a potent PARP-1 inhibitor derived from 7-azaindole-1-carboxamide by Dallavalle, Sabrina, Musso, Loana, Artali, Roberto, Aviñó, Anna, Scaglioni, Leonardo, Eritja, Ramon, Gargallo, Raimundo, Mazzini, Stefania

“…Poly ADP-ribose polymerases (PARP) are key proteins involved in DNA repair, maintenance as well as regulation of programmed cell death. For this reason they…”
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A pH-dependent bolt involving cytosine bases located in the lateral loops of antiparallel G-quadruplex structures within the SMARCA4 gene promotor by Benabou, Sanae, Mazzini, Stefania, Aviñó, Anna, Eritja, Ramon, Gargallo, Raimundo

“…Some lung and ovarian tumors are connected to the loss of expression of SMARCA4 gene. In its promoter region, a 44-nucleotides long guanine sequence prone to…”
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Aptamer-Drug conjugates for a targeted and synergistic anticancer Response: Exploiting T30923-5-fluoro-2′-deoxyuridine (INT-FdU) derivatives by Benigno, Daniela, Navarro, Natalia, Aviñó, Anna, Esposito, Veronica, Galeone, Aldo, Virgilio, Antonella, Fàbrega, Carme, Eritja, Ramon

“…[Display omitted] One of the most appealing approaches for cancer treatment is targeted therapy, which is based on the use of drugs able to target cancer cells…”
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Stabilization of c-KIT G-Quadruplex DNA Structures by the RNA Polymerase I Inhibitors BMH-21 and BA-41 by Mazzini, Stefania, Gargallo, Raimundo, Musso, Loana, De Santis, Francesca, Aviñó, Anna, Scaglioni, Leonardo, Eritja, Ramon, Di Nicola, Massimo, Zunino, Franco, Amatulli, Annabella, Dallavalle, Sabrina

“…The stabilization of G-quadruplex DNA structures by small molecules with affinity to oncogene promoters has emerged as a promising anticancer strategy, due to…”
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Exploring the stabilizing effect on the i-motif of neighboring structural motifs and drugs by Rodriguez, Judit, Domínguez, Arnau, Aviñó, Anna, Borgonovo, Gigliola, Eritja, Ramon, Mazzini, Stefania, Gargallo, Raimundo

“…Cytosine-rich DNA sequences may fold into a structure known as i-motif, with potential in vivo modulation of gene expression. The stability of the i-motif is…”
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Detection of pyrimidine-rich DNA sequences based on the formation of parallel and antiparallel triplex DNA and fluorescent silver nanoclusters by García, Juan Fernando, Reguera, David, Valls, Andrea, Aviñó, Anna, Dominguez, Arnau, Eritja, Ramon, Gargallo, Raimundo

“…[Display omitted] •Assessment of triplex DNA by means of spectroscopy and multivariate analysis.•Development of silver nanoclusters sensors based on triplex…”
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Study of conformational transitions of i-motif DNA using time-resolved fluorescence and multivariate analysis methods by Benabou, Sanae, Ruckebusch, Cyril, Sliwa, Michel, Aviñó, Anna, Eritja, Ramon, Gargallo, Raimundo, de Juan, Anna

“…Recently, the presence of i-motif structures at C-rich sequences in human cells and their regulatory functions have been demonstrated. Despite numerous…”
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Sensitive and label-free detection of miRNA-145 by triplex formation by Aviñó, Anna, Huertas, César S, Lechuga, Laura M, Eritja, Ramon

“…The development of new strategies for detecting microRNAs (miRNAs) has become a crucial step in the diagnostic field. miRNA profiles depend greatly on the…”
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Exploring the Interaction of G-quadruplex Binders with a (3 + 1) Hybrid G-quadruplex Forming Sequence within the PARP1 Gene Promoter Region by Mazzini, Stefania, Princiotto, Salvatore, Artali, Roberto, Musso, Loana, Aviñó, Anna, Eritja, Ramon, Gargallo, Raimundo, Dallavalle, Sabrina

“…The enzyme PARP1 is an attractive target for cancer therapy, as it is involved in DNA repair processes. Several PARP1 inhibitors have been approved for…”
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Engineering ternary systems as non-viral vehicles for transporting floxuridine oligomer by Staëlen, Margaux, Espinosa, Victor, Jacquemet, Margot, Aviñó, Anna, García-Celma, María José, Eritja, Ramon, Rodriguez-Abreu, Carlos, Grijalvo, Santiago

“…[Display omitted] •PLGA NPs were prepared from nano-emulsion templates using PIC low energy methods.•FdU/CHI/PLGA ternary system was bound electrostatically…”
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Selective depletion of metastatic stem cells as therapy for human colorectal cancer by Céspedes, María Virtudes, Unzueta, Ugutz, Aviñó, Anna, Gallardo, Alberto, Álamo, Patricia, Sala, Rita, Sánchez‐Chardi, Alejandro, Casanova, Isolda, Mangues, María Antònia, Lopez‐Pousa, Antonio, Eritja, Ramón, Villaverde, Antonio, Vázquez, Esther, Mangues, Ramón

“…Selective elimination of metastatic stem cells (MetSCs) promises to block metastatic dissemination. Colorectal cancer (CRC) cells overexpressing CXCR4 display…”
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Evaluation of Floxuridine Oligonucleotide Conjugates Carrying Potential Enhancers of Cellular Uptake by Aviñó, Anna, Clua, Anna, Bleda, Maria José, Eritja, Ramon, Fàbrega, Carme

“…Conjugation of small molecules such as lipids or receptor ligands to anti-cancer drugs has been used to improve their pharmacological properties. In this work,…”
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Defined covalent attachment of three cancer drugs to DNA origami increases cytotoxicity at nanomolar concentration by Navarro, Natalia, Aviñó, Anna, Domènech, Òscar, Borrell, Jordi H, Eritja, Ramon, Fàbrega, Carme

“…DNA nanostructures have captured great interest as drug delivery vehicles for cancer therapy. Despite rapid progress in the field, some hurdles, such as low…”
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Surface decoration of PLGA nanoparticles enables efficient transport of floxuridine oligomers into mammalian cells by Barnaud, Laura, Fukuhara, Solène, Pava, Mateo, Carrasco, Marc, Aviñó, Anna, Eritja, Ramon, Rodriguez-Abreu, Carlos, Grijalvo, Santiago

“…2′-deoxy-5-fluorouridine (Floxuridine, FdU) oligomers are repeated FdU residues linked to each other through phosphate groups exhibiting anticancer properties…”
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