Search Results - "Avila, Matías"

The EGFR signalling system in the liver: from hepatoprotection to hepatocarcinogenesis by Berasain, Carmen, Avila, Matías A.

“…The liver displays an outstanding wound healing and regenerative capacity unmatched by any other organ. This reparative response is governed by a complex…”
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Amphiregulin by Berasain, Carmen, Avila, Matías A.

“…•Amphiregulin binds EGFR and signals in juxtacrine, autocrine and paracrine manners.•Amphiregulin stimulates cell growth, survival and migration.•Amphiregulin…”
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Hydroxymethylbilane synthase (aka porphobilinogen deaminase): A novel metabolic tumor suppressor gene in hepatocellular carcinoma by Fontanellas, Antonio, Avila, Matías A.

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Regulation of hepatocyte identity and quiescence by Berasain, Carmen, Avila, Matías A

“…The liver is a highly differentiated organ with a central role in metabolism, detoxification and systemic homeostasis. To perform its multiple tasks, liver…”
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Loss of liver function in chronic liver disease: An identity crisis by Berasain, Carmen, Arechederra, Maria, Argemí, Josepmaria, Fernández-Barrena, Maite G., Avila, Matías A.

“…Adult hepatocyte identity is constructed throughout embryonic development and fine-tuned after birth. A multinodular network of transcription factors, along…”
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Inhibiting Cytokinesis in the Liver: A New Way to Reduce Tumor Development by Desdouets, Chantal, Avila, Matías A.

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Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice by Uriarte, Iker, Fernandez-Barrena, Maite G, Monte, Maria J, Latasa, Maria U, Chang, Haisul C Y, Carotti, Simone, Vespasiani-Gentilucci, Umberto, Morini, Sergio, Vicente, Eva, Concepcion, Axel R, Medina, Juan F, Marin, José Juan G, Berasain, Carmen, Prieto, Jesus, Avila, Matías A

“…Cholestasis is associated with increased liver injury and morbidity after partial hepatectomy (PH), yet bile acids (BAs) are emerging as important mediators of…”
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Porphyrins and the porphyrias by Fontanellas, Antonio, Avila, Matías A, Deybach, Jean-Charles, Badminton, Michael N

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The anticoagulant rivaroxaban lowers portal hypertension in cirrhotic rats mainly by deactivating hepatic stellate cells by Vilaseca, Marina, García‐Calderó, Héctor, Lafoz, Erica, García‐Irigoyen, Oihane, Avila, Matías A., Reverter, Joan Carles, Bosch, Jaume, Hernández‐Gea, Virginia, Gracia‐Sancho, Jordi, García‐Pagán, Joan Carles

“…In cirrhosis, increased intrahepatic vascular resistance (IHVR) is the primary factor for portal hypertension (PH) development. Hepatic stellate cells (HSCs)…”
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Epigenetic Mechanisms in Gastric Cancer: Potential New Therapeutic Opportunities by Canale, Matteo, Casadei-Gardini, Andrea, Ulivi, Paola, Arechederra, Maria, Berasain, Carmen, Lollini, Pier-Luigi, Fernández-Barrena, Maite G, Avila, Matías A

“…Gastric cancer (GC) is one of the deadliest malignancies worldwide. Complex disease heterogeneity, late diagnosis, and suboptimal therapies result in the poor…”
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Sweet dreams could be made of this: carbohydrate‐responsive element‐binding protein (ChREBP) as a target for hepatocellular carcinoma therapy by Fernández‐Barrena, Maite G., Avila, Matías A.

“…Rewiring of cellular metabolism is now fully recognized as a hallmark of cancer. Tumor cells reprogram metabolic pathways to meet the energetic and…”
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HOXD8 hypermethylation as a fully sensitive and specific biomarker for biliary tract cancer detectable in tissue and bile samples by Loi, Eleonora, Zavattari, Cesare, Tommasi, Alessandro, Moi, Loredana, Canale, Matteo, Po, Agnese, Sabato, Claudia, Vega-Benedetti, Ana Florencia, Ziranu, Pina, Puzzoni, Marco, Lai, Eleonora, Faloppi, Luca, Rullán, María, Carrascosa, Juan, Amat, Irene, Urman, Jesús M., Arechederra, Maria, Berasain, Carmen, Ferretti, Elisabetta, Casadei-Gardini, Andrea, Avila, Matías A., Alonso, Sergio, Scartozzi, Mario, Zavattari, Patrizia

“…Background Biliary tract cancers (BTC) are rare but highly aggressive tumours with poor prognosis, usually detected at advanced stages. Herein, we aimed at…”
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Overexpression of the Transcription Factor MEF2D in Hepatocellular Carcinoma Sustains Malignant Character by Suppressing G2―M Transition Genes by LEINA MA, JIA LIU, PING BIE, YOUHONG CUI, BIAN, Xiu-Wu, PRIETO, Jesus, AVILA, Matías A, CHENG QIAN, LIMEI LIU, GUANGJIE DUAN, QINGLIANG WANG, YANMIN XU, FENG XIA, JUANJUAN SHAN, JUNJIE SHEN, ZHI YANG

“…The underlying molecular pathogenesis in hepatocellular carcinoma remains poorly understood. The transcription factor MEF2D promotes survival in various cell…”
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The TGF-β Pathway: A Pharmacological Target in Hepatocellular Carcinoma? by Gonzalez-Sanchez, Ester, Vaquero, Javier, Férnandez-Barrena, Maite G., Lasarte, Juan José, Avila, Matías A., Sarobe, Pablo, Reig, María, Calvo, Mariona, Fabregat, Isabel

“…Transforming Growth Factor-beta (TGF-β) superfamily members are essential for tissue homeostasis and consequently, dysregulation of their signaling pathways…”
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Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells by CASTILLO, Josefa, ERROBA, Elena, PERUGORRIA, Maria J, SANTAMARIA, Monica, LEE, David C, PRIETO, Jesus, AVILA, Matias A, BERASAIN, Carmen

“…Hepatocellular carcinoma is a major cause of cancer-related deaths. Current treatments are not effective, and the identification of relevant pathways and novel…”
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Hepatocyte dedifferentiation profiling in alcohol-related liver disease identifies CXCR4 as a driver of cell reprogramming by Aguilar-Bravo, Beatriz, Ariño, Silvia, Blaya, Delia, Pose, Elisa, Martinez García de la Torre, Raquel A., Latasa, María U., Martínez-Sánchez, Celia, Zanatto, Laura, Sererols-Viñas, Laura, Cantallops-Vilà, Paula, Affo, Silvia, Coll, Mar, Thillen, Xavier, Dubuquoy, Laurent, Avila, Matías A., Argemi, Josepmaria, Paz, Arantza Lamas, Nevzorova, Yulia A., Cubero, Francisco Javier, Bataller, Ramon, Lozano, Juan José, Ginès, Pere, Mathurin, Philippe, Sancho-Bru, Pau

“…Loss of hepatocyte identity is associated with impaired liver function in alcohol-related hepatitis (AH). In this context, hepatocyte dedifferentiation gives…”
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Frontiers in fatty liver: recent advances in pathogenic mechanisms, assessment of patients' prognosis and pharmacotherapy by Fernández-Barrena, Maite G, Avila, Matías A

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Bile acids, FGF15/19 and liver regeneration: From mechanisms to clinical applications by Alvarez-Sola, Gloria, Uriarte, Iker, Latasa, Maria U., Jimenez, Maddalen, Barcena-Varela, Marina, Santamaría, Eva, Urtasun, Raquel, Rodriguez-Ortigosa, Carlos, Prieto, Jesús, Berraondo, Pedro, Fernandez-Barrena, Maite G., Berasain, Carmen, Avila, Matías A.

“…The liver has an extraordinary regenerative capacity rapidly triggered upon injury or resection. This response is intrinsically adjusted in its initiation and…”
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Targeting CCL2/CCR2 in Tumor-Infiltrating Macrophages: A Tool Emerging Out of the Box Against Hepatocellular Carcinoma by Avila, Matías A., BPharm, PhD, Berasain, Carmen, PhD

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Regulation of amphiregulin gene expression by β-catenin signaling in human hepatocellular carcinoma cells: a novel crosstalk between FGF19 and the EGFR system by Latasa, Maria U, Salis, Fabiana, Urtasun, Raquel, Garcia-Irigoyen, Oihane, Elizalde, Maria, Uriarte, Iker, Santamaria, Monica, Feo, Francesco, Pascale, Rosa M, Prieto, Jesús, Berasain, Carmen, Avila, Matías A

“…Hepatocellular carcinoma (HCC) is the most prevalent liver tumor and a deadly disease with limited therapeutic options. Dysregulation of cell signaling…”
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