Search Results - "Avilés, Pablo M"

Quantitative determination of lurbinectedin, its unbound fraction and its metabolites in human plasma utilizing ultra-performance LC-MS/MS by King, Nicholas, Garcia-Martinez, Soledad, Alcaraz, Eider, Grisalena, Alba, Lubomirov, Rubin, Altares, Raquel, Fernandez-Teruel, Carlos, Francesch, Andrés M, Avilés, Pablo M, Fudio, Salvador

“…Ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) methods to quantify total lurbinectedin, its plasma protein binding to derive the…”
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Plocabulin, a novel tubulin inhibitor, has potent antitumor activity in patient-derived xenograft models of gastrointestinal stromal tumors by Wang, Yannick, Wozniak, Agnieszka, Wellens, Jasmien, Gebreyohannes, Yemarshet K., Guillén, Maria Jose, Avilés, Pablo M., Debiec-Rychter, Maria, Sciot, Raf, Schöffski, Patrick

“…The majority of patients with gastrointestinal stromal tumors (GIST) eventually become resistant with time due to secondary mutations in the driver receptor…”
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Supervised Triple Macrosynchronized Lockstep (STMLS) Architecture for Multicore Processors by Aviles, Pablo M., Belloch, Jose A., Entrena, Luis, Lindoso, Almudena

“…In various fields, such as those with high-reliability requirements, there is a growing demand for high-performance microprocessors. Whereas commercial…”
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Radiation Testing of a Multiprocessor Macrosynchronized Lockstep Architecture With FreeRTOS by Aviles, Pablo M., Lindoso, Almudena, Belloch, Jose A., Garcia-Valderas, Mario, Morilla, Yolanda, Entrena, Luis

“…Nowadays, high-performance microprocessors are demanded in many fields, including those with high-reliability requirements. Commercial microprocessors present…”
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Hardening Architectures for Multiprocessor System-on-Chip by Aviles, Pablo M., Garcia-Astudillo, Luis A., Entrena, Luis, Garcia-Valderas, Mario, Martin-Holgado, Pedro, Morilla, Yolanda, Lindoso, Almudena

“…New Space missions require a short design cycle with reduced design costs and high computational capabilities. Current terrestrial commercial off-the-shelf…”
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Hybrid Hardening Approach for a Fault-Tolerant RISC-V System-On-Chip by Santos, Douglas A., Aviles, Pablo M., Mattos, Andre M. P., Garcia-Valderas, Mario, Entrena, Luis, Lindoso, Almudena, Dilillo, Luigi

“…The New Space era has driven a wide array of applications in novel space missions with an increasing demand for processors with high computational capabilities…”
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Hybrid CPU–GPU implementation of the transformed spatial domain channel estimation algorithm for mmWave MIMO systems by Lloria, Diego, Aviles, Pablo M., Belloch, Jose A., Roger, Sandra, Botella-Mascarell, Carmen, Lindoso, Almudena

“…Hybrid platforms combining multicore central processing units (CPU) with many-core hardware accelerators such as graphic processing units (GPU) can be smartly…”
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Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus by Harlow, Matt L, Maloney, Nichole, Roland, Joseph, Guillen Navarro, Maria Jose, Easton, Matthew K, Kitchen-Goosen, Susan M, Boguslawski, Elissa A, Madaj, Zachary B, Johnson, Ben K, Bowman, Megan J, D'Incalci, Maurizio, Winn, Mary E, Turner, Lisa, Hostetter, Galen, Galmarini, Carlos María, Aviles, Pablo M, Grohar, Patrick J

“…There is a great need to develop novel approaches to target oncogenic transcription factors with small molecules. Ewing sarcoma is emblematic of this need, as…”
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Performance analysis of a millimeter wave MIMO channel estimation method in an embedded multi-core processor by Aviles, Pablo M., Lloria, Diego, Belloch, Jose A., Roger, Sandra, Lindoso, Almudena, Cobos, Maximo

“…The emerging Multi-Processor System-on-Chip (MPSoC) technology, which combines heterogeneous computing with the high performance of field programmable gate…”
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Abstract 1880: Ecubectedin and PM54 demonstrate antitumor activity in patient-derived xenograft models of soft tissue sarcoma by Gorgels, Daniël, Wozniak, Agnieszka, Wang, Chao-Chi, Avilés, Pablo M., Guillen, Maria J., Cuevas, Carmen, Schöffski, Patrick

“…Abstract Objective: Soft tissue sarcoma (STS) is a heterogenous group of rare, malignant tumors arising from mesenchymal tissue. Doxorubicin (DOX)-based…”
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Abstract 3840: Plocabulin, a tubulin inhibitor, presents antitumor activity in patient-derived xenograft (PDX) models of gastrointestinal stromal tumor (GIST) by Wozniak, Agnieszka, Wang, Yannick, Wellens, Jasmien, Gebreyohannes, Yemarshet K., Guillén, Maria Jose, Galmarini, Carlos M., Avilés, Pablo M., Debiec-Rychter, Maria, Sciot, Raf, Schöffski, Patrick

“…Abstract Introduction: Advanced GIST is commonly treated with tyrosine kinase inhibitors (TKI) [e.g. imatinib (IMA)]. With time the vast majority of patients…”
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Quantitative determination of lurbinectedin, its unbound fraction and its metabolites in human plasma utilizing ultra-performance LC–MS/MS by Nicholas King, Soledad Garcia-Martinez, Eider Alcaraz, Alba Grisalena, Rubin Lubomirov, Raquel Altares, Carlos Fernandez-Teruel, Andrés M. Francesch, Pablo M. Avilés, Salvador Fudio

“…Aims Ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) methods to quantify total lurbinectedin, its plasma protein binding to…”
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Evaluating reliability through soft error triggered exceptions at ARM Cortex-A9 microprocessor by Aviles, Pablo M., Lindoso, Almudena, Belloch, Jose A., Entrena, Luis

“…ARM Cortex-A9 is a high-end microprocessor present in multiple programmable System-on-Chip that is used in many application fields, including those with high…”
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High complexity reliable space applications in commercial microprocessors by Aviles, Pablo M., Schäfer, Laura, Lindoso, Almudena, Belloch, Jose A., Entrena, Luis

“…Reliability requirements are critical in applications used in harsh environments. Although commercial microprocessors offer a good trade-off between cost,…”
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Abstract 4472: Plitidepsin shows antitumor activity in patient-derived tumor xenografts and hematologic malignancies by Maier, Armin, Kelter, Gerhard, Vuaroquaux, Vincent, Avilés Marin, Pablo M., Cuevas, Carmen, Galmarini, Carlos M., Fiebig, Heinz H.

“…Abstract Plitidepsin is a new marine-derived anti-tumor agent, originally isolated from the tunicate Aplidium albicans that is now fully obtained by total…”
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Abstract 2542: Lurbinectedin (PM01183) synergizes in vivo the antitumor activity of doxorubicin in SCLC tumor xenografts by Guillen, Maria Jose, Cataluña, Oscar, Palomares, Mandy, Lopez, Raquel, Nuñez, Praxedes, Cuevas, Carmen, Aviles, Pablo M.

“…Abstract Background: Lurbinectedin (PM01183) is a synthetic tetrahydroisoquinoline alkaloid currently evaluated as single agent and in combination in phase I…”
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Abstract A172: PM060184 is a new tubulin binding agent that induces strong antitumor activity in xenografted tumors by Guillén, Maria José, Cataluña, Oscar, Palomares, Mandy, Aviles, Pablo M.

“…Abstract PM060184 is a new synthetic tubulin-binding agent, originally isolated from the marine sponge Lithoplocamia lithistoides. PM060184 has demonstrated to…”
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INSP-15. ITCC-P4: A sustainable platform of molecularly well-characterized PDX models of pediatric cancers for high throughput in vivo testing by Kool, Marcel, Federico, Aniello, Surdez, Didier, Gopisetty, Apurva, Saberi-Ansari, Elnaz, Saint-Charles, Alexandra, Iddir, Yasmine, Waterfall, Joshua, Wierzbinska, Justyna, Schlicker, Andreas, Bhalsankar, Jaydutt, Mack, Norman, Schwalm, Benjamin, Böttcher, Anna-Lisa, Sill, Martin, Westermann, Frank, Jones, David T W, Volckmann, Richard, Zwijnenburg, Danny, Gürgen, Dennis, Inderise, Emilie, Schulte, Johannes, Eggert, Angelika, Molenaar, Jan J, Delattre, Olivier, Colombetti, Sara, Heidenreich, Olaf, Jeremias, Irmela, Scotlandi, Katia, Manara, Maria Cristina, Gojo, Johannes, Berger, Walter, Iradier, Fatima, Geoerger, Birgit, Costa, Jenny, Schäfer, Beat, Wachtel, Marco, Chesler, Louis, Jones, Chris, Kovar, Heinrich, Carcaboso, Ángel Montero, Klusmann, Jan-Henning, Debatin, Klaus-Michael, Bomken, Simon, Guttke, Christina, Hamerlik, Petra, Hattersley, Maureen, Garcia, Michelle, Colland, Frédéric, Strougo, Ashley, Witt, Olaf, Vassal, Gilles, Caron, Hubert, Shields, David J, Stancato, Lou F, Aviles, Pablo M, Hoffmann, Jens, Cairo, Stefano, Schueler, Julia, Jäger, Natalie, Koster, Jan, Schleiermacher, Gudrun, Pfister, Stefan M

“…Abstract Thanks to state-of-the-art molecular profiling techniques we by now have a much better understanding of pediatric cancers and what is driving them. On…”
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Abstract 4534: In vivo antitumor activity of PM060184 in patient-derived xenografted tumors (avatar) by Hidalgo, Manuel, Guillén, M. José, López-Casas, Pedro Pablo, Sarno, Francesca, Cataluña, Oscar, Palomares, Mandy, Cuevas, Carmen, Aviles, Pablo M.

“…Abstract Background: PM060184 is a synthetic marine-derived compound originally isolated from the marine sponge Lithoplocamia lithistoides. PM060184 induces…”
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Abstract 4654: Plasma, tissue and tumor pharmacokinetics of PM060184 in NSCL xenograft mouse model by Pernice, Tiziana, Bishop, Alan, Cataluña, Oscar, Palomares, Mandy, Lopez, Raquel, Núñez, Práxedes, Cuevas, Carmen, Guillén, Maria José, Aviles, Pablo M.

“…Abstract Background: PM060184 is new marine derived tubulin-binding agent originally isolated from the sponge Lithoplocamia lithistoides. PM060184 has shown…”
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