Search Results - "Avichai Tendler"

A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks by Karin, Omer, Raz, Moriya, Tendler, Avichai, Bar, Alon, Korem Kohanim, Yael, Milo, Tomer, Alon, Uri

“…Stress activates a complex network of hormones known as the hypothalamic–pituitary–adrenal (HPA) axis. The HPA axis is dysregulated in chronic stress and…”
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Evolutionary tradeoffs, Pareto optimality and the morphology of ammonite shells by Tendler, Avichai, Mayo, Avraham, Alon, Uri

“…Organisms that need to perform multiple tasks face a fundamental tradeoff: no design can be optimal at all tasks at once. Recent theory based on Pareto…”
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Noise-precision tradeoff in predicting combinations of mutations and drugs by Tendler, Avichai, Zimmer, Anat, Mayo, Avi, Alon, Uri

“…Many biological problems involve the response to multiple perturbations. Examples include response to combinations of many drugs, and the effects of…”
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Hormone seasonality in medical records suggests circannual endocrine circuits by Tendler, Avichai, Bar, Alon, Mendelsohn-Cohen, Netta, Karin, Omer, Kohanim, Yael Korem, Maimon, Lior, Milo, Tomer, Raz, Moriya, Mayo, Avi, Tanay, Amos, Alon, Uri

“…Hormones control the major biological functions of stress response, growth, metabolism, and reproduction. In animals, these hormones show pronounced…”
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Prediction of drug cocktail effects when the number of measurements is limited by Zimmer, Anat, Tendler, Avichai, Katzir, Itay, Mayo, Avi, Alon, Uri

“…Cocktails of drugs can be more effective than single drugs, because they can potentially work at lower doses and avoid resistance. However, it is impossible to…”
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Major depressive disorder and bistability in an HPA-CNS toggle switch by Ron Mizrachi, Ben, Tendler, Avichai, Karin, Omer, Milo, Tomer, Haran, Dafna, Mayo, Avi, Alon, Uri

“…Major depressive disorder (MDD) is the most common psychiatric disorder. It has a complex and heterogeneous etiology. Most treatments take weeks to show…”
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Inferring biological tasks using Pareto analysis of high-dimensional data by Hart, Yuval, Sheftel, Hila, Hausser, Jean, Szekely, Pablo, Ben-Moshe, Noa Bossel, Korem, Yael, Tendler, Avichai, Mayo, Avraham E, Alon, Uri

“…Pareto task inference (ParTI) computes a polytype that encloses a data set and determines the enrichment of features around the vertices (archetypes) of the…”
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Creative foraging: An experimental paradigm for studying exploration and discovery by Hart, Yuval, Mayo, Avraham E, Mayo, Ruth, Rozenkrantz, Liron, Tendler, Avichai, Alon, Uri, Noy, Lior

“…Creative exploration is central to science, art and cognitive development. However, research on creative exploration is limited by a lack of high-resolution…”
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Fold-change Response of Photosynthesis to Step Increases of Light Level by Tendler, Avichai, Wolf, Bat Chen, Tiwari, Vivekanand, Alon, Uri, Danon, Avihai

“…Plants experience light intensity over several orders of magnitude. High light is stressful, and plants have several protective feedback mechanisms against…”
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Endocrine Autoimmune Disease as a Fragility of Immune Surveillance against Hypersecreting Mutants by Korem Kohanim, Yael, Tendler, Avichai, Mayo, Avi, Friedman, Nir, Alon, Uri

“…Some endocrine organs are frequent targets of autoimmune attack. Here, we addressed the origin of autoimmune disease from the viewpoint of feedback control…”
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Major depressive disorder and bistability in an HPA-CNS toggle switch by Ben Ron Mizrachi, Avichai Tendler, Omer Karin, Tomer Milo, Dafna Haran, Avi Mayo, Uri Alon

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Anxiety in the face of the first wave of the spread of COVID-19 in Israel: Psychosocial determinants of a “Panic-to-complacency-continuum” by Shahar, Golan, Ahronson-Daniel, Limor, Greenberg, David, Shalev, Hadar, Tendler, Avichai, Grotto, Itamar, Malone, Patrick, Davidovitch, Nadav

“…Based on an established ongoing prospective-longitudinal study examining anxiety in response to COVID-19, a representative sample of 1018 Jewish-Israeli adults…”
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Changes in General and Virus-Specific Anxiety During the Spread of COVID-19 in Israel: A 7-Wave Longitudinal Study by Shahar, Golan, Aharonson-Daniel, Limor, Greenberg, David, Shalev, Hadar, Malone, Patrick S, Tendler, Avichai, Grotto, Itamar, Davidovitch, Nadav

“…We compared 3 hypothetical trajectories of change in both general and coronavirus disease 2019 (COVID-19)-specific anxiety during the first wave of the spread…”
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Changes in General and Virus-Specific Anxiety during the Spread of COVID-19 In Israel: A Seven-Wave Longitudinal Study by Shahar, Golan, Aharonson-Daniel, Limor, Greenberg, David, Shalev, Hadar, Malone, Patrick S, Tendler, Avichai, Grotto, Itamar, Davidovitch, Nadav

“…We compared three hypothetical trajectories of change in both general and COVID-19-specific anxiety during the 1 st wave of the spread in the state of Israel:…”
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Continuum of Gene-Expression Profiles Provides Spatial Division of Labor within a Differentiated Cell Type by Adler, Miri, Korem Kohanim, Yael, Tendler, Avichai, Mayo, Avi, Alon, Uri

“…Single-cell gene expression reveals the diversity within a differentiated cell type. Often, cells of the same type show a continuum of gene-expression…”
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Controls for Phylogeny and Robust Analysis in Pareto Task Inference by Adler, Miri, Tendler, Avichai, Hausser, Jean, Korem, Yael, Szekely, Pablo, Bossel, Noa, Hart, Yuval, Karin, Omer, Mayo, Avi, Alon, Uri

“…Abstract Understanding the tradeoffs faced by organisms is a major goal of evolutionary biology. One of the main approaches for identifying these tradeoffs is…”
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Tradeoffs and Optimality in Biological Systems by Tendler, Avichai

“…In this work we study design principles of biological systems which face tradeoffs using mathematical tools from systems biology. We study this general problem…”
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Geometric Class Field Theory by Tendler, Avichai

“…In this paper we prove global class field theory using a purely geometric result. We first write in detail Deligne's proof to the unramified case of class…”
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Approximating Functions on Boxes by Tendler, Avichai, Alon, Uri

“…The vector space of all polynomial functions of degree $k$ on a box of dimension $n$ is of dimension ${n \choose k}$. A consequence of this fact is that a…”
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Creative Foraging: A Quantitative Paradigm for Studying Creative Exploration by Hart, Yuval, Mayo, Avraham E, Mayo, Ruth, Rozenkrantz, Liron, Tendler, Avichai, Alon, Uri, Noy, Lior

“…Creative exploration is central to science, art and cognitive development. However, research on creative exploration is limited by a lack of high-resolution…”
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