Search Results - "Avey, Denis"

Inferring protein expression changes from mRNA in Alzheimer’s dementia using deep neural networks by Tasaki, Shinya, Xu, Jishu, Avey, Denis R., Johnson, Lynnaun, Petyuk, Vladislav A., Dawe, Robert J., Bennett, David A., Wang, Yanling, Gaiteri, Chris

“…Identifying the molecular systems and proteins that modify the progression of Alzheimer’s disease and related dementias (ADRD) is central to drug target…”
Get full text

Single-Cell RNA-Seq Uncovers a Robust Transcriptional Response to Morphine by Glia by Avey, Denis, Sankararaman, Sumithra, Yim, Aldrin K.Y., Barve, Ruteja, Milbrandt, Jeffrey, Mitra, Robi D.

“…Molecular and behavioral responses to opioids are thought to be primarily mediated by neurons, although there is accumulating evidence that other cell types…”
Get full text

High-throughput single-cell functional elucidation of neurodevelopmental disease-associated genes reveals convergent mechanisms altering neuronal differentiation by Lalli, Matthew A, Avey, Denis, Dougherty, Joseph D, Milbrandt, Jeffrey, Mitra, Robi D

“…The overwhelming success of exome- and genome-wide association studies in discovering thousands of disease-associated genes necessitates developing novel…”
Get full text

Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia by Wang, Peter L., Yim, Aldrin K. Y., Kim, Ki-Wook, Avey, Denis, Czepielewski, Rafael S., Colonna, Marco, Milbrandt, Jeffrey, Randolph, Gwendalyn J.

“…Whereas microglia are recognized as fundamental players in central nervous system (CNS) development and function, much less is known about macrophages of the…”
Get full text

Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein by Wu, Jian-jun, Li, Wenwei, Shao, Yaming, Avey, Denis, Fu, Bishi, Gillen, Joseph, Hand, Travis, Ma, Siming, Liu, Xia, Miley, Wendell, Konrad, Andreas, Neipel, Frank, Stürzl, Michael, Whitby, Denise, Li, Hong, Zhu, Fanxiu

“…Invading viral DNA can be recognized by the host cytosolic DNA sensor, cyclic GMP-AMP (cGAMP) synthase (cGAS), resulting in production of the second messenger…”
Get full text

Phosphoproteomic Analysis of KSHV-Infected Cells Reveals Roles of ORF45-Activated RSK during Lytic Replication by Avey, Denis, Tepper, Sarah, Li, Wenwei, Turpin, Zachary, Zhu, Fanxiu

“…Kaposi's Sarcoma-Associated Herpesvirus (KSHV) is an oncogenic virus which has adapted unique mechanisms to modulate the cellular microenvironment of its human…”
Get full text

Kaposi's Sarcoma-Associated Herpesvirus Inhibitor of cGAS (KicGAS), Encoded by ORF52, Is an Abundant Tegument Protein and Is Required for Production of Infectious Progeny Viruses by Li, Wenwei, Avey, Denis, Fu, Bishi, Wu, Jian-Jun, Ma, Siming, Liu, Xia, Zhu, Fanxiu

“…Although Kaposi's sarcoma-associated herpesvirus (KSHV) ORF52 (also known as KSHV inhibitor of cGAS [KicGAS]) has been detected in purified virions, the roles…”
Get full text

SR-TWAS: leveraging multiple reference panels to improve transcriptome-wide association study power by ensemble machine learning by Parrish, Randy L., Buchman, Aron S., Tasaki, Shinya, Wang, Yanling, Avey, Denis, Xu, Jishu, De Jager, Philip L., Bennett, David A., Epstein, Michael P., Yang, Jingjing

“…Multiple reference panels of a given tissue or multiple tissues often exist, and multiple regression methods could be used for training gene expression…”
Get full text

Differential gene expression analysis based on linear mixed model corrects false positive inflation for studying quantitative traits by Tang, Shizhen, Buchman, Aron S., Wang, Yanling, Avey, Denis, Xu, Jishu, Tasaki, Shinya, Bennett, David A., Zheng, Qi, Yang, Jingjing

“…Differential gene expression (DGE) analysis has been widely employed to identify genes expressed differentially with respect to a trait of interest using RNA…”
Get full text

ORF45-Mediated Prolonged c-Fos Accumulation Accelerates Viral Transcription during the Late Stage of Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus by Li, Xiaojuan, Du, Shumin, Avey, Denis, Li, Yuqing, Zhu, Fanxiu, Kuang, Ersheng

“…Kaposi's sarcoma-associated herpesvirus (KSHV) encodes multiple viral proteins that activate extracellular signal-regulated kinase (ERK)-mitogen-activated…”
Get full text

Activation of p90 ribosomal S6 kinases by ORF45 of Kaposi's sarcoma-associated herpesvirus is critical for optimal production of infectious viruses by Fu, Bishi, Kuang, Ersheng, Li, Wenwei, Avey, Denis, Li, Xiaojuan, Turpin, Zachary, Valdes, Ahmed, Brulois, Kevin, Myoung, Jinjong, Zhu, Fanxiu

“…We have previously shown that ORF45, an immediate-early and tegument protein of Kaposi's sarcoma-associated herpesvirus (KSHV), causes sustained activation of…”
Get full text

Discovery of a Coregulatory Interaction between Kaposi's Sarcoma-Associated Herpesvirus ORF45 and the Viral Protein Kinase ORF36 by Avey, Denis, Tepper, Sarah, Pifer, Benjamin, Bahga, Amritpal, Williams, Hunter, Gillen, Joseph, Li, Wenwei, Ogden, Sarah, Zhu, Fanxiu

“…Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of three human malignancies. KSHV ORF36 encodes a serine/threonine viral protein kinase,…”
Get full text

ORF33 and ORF38 of Kaposi's Sarcoma-Associated Herpesvirus Interact and Are Required for Optimal Production of Infectious Progeny Viruses by Wu, Jian-Jun, Avey, Denis, Li, Wenwei, Gillen, Joseph, Fu, Bishi, Miley, Wendell, Whitby, Denise, Zhu, Fanxiu

“…We recently showed that the interaction between Kaposi's sarcoma-associated herpesvirus (KSHV) tegument proteins ORF33 and ORF45 is crucial for progeny virion…”
Get full text

Recent advances in the study of Kaposi’s sarcoma-associated herpesvirus replication and pathogenesis by Avey, Denis, Brewers, Brittany, Zhu, Fanxiu

“…It has now been over twenty years since a novel herpesviral genome was identified in Kaposi’s sarcoma biopsies. Since then, the cumulative research effort by…”
Get full text

Changes in nucleosome occupancy occur in a chromosome specific manner by Sexton, Brittany S., Druliner, Brooke R., Avey, Denis, Zhu, Fanxiu, Dennis, Jonathan H.

“…In the eukaryotic nucleus, DNA is packaged into chromatin. The fundamental subunit of chromatin is the nucleosome, DNA is wrapped 1.6 times around a histone…”
Get full text

Elucidating Cell Diversity and Functions of Human Brain Borders in Alzheimer’s Disease by Kearns, Nicola, Iatrou, Artemis, Avey, Denis, Yu, Chunjiang, Philippe, Tristan, Flood, Daniel, De Tissera, Sashini L, Mullaney, Zachary, Xu, Jishu, Gaiteri, Chris, Bennett, David A. A, Wang, Yanling

“…Background Emerging evidence shows that the brain border regions act as a functional neuro‐immune interface to conduct essential immune surveillance and immune…”
Get full text

A survey of the interactome of Kaposi's sarcoma-associated herpesvirus ORF45 revealed its binding to viral ORF33 and cellular USP7, resulting in stabilization of ORF33 that is required for production of progeny viruses by Gillen, Joseph, Li, Wenwei, Liang, Qiming, Avey, Denis, Wu, Jianjun, Wu, Fayi, Myoung, JinJong, Zhu, Fanxiu

“…The ORF45 protein of Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus-specific immediate-early tegument protein. Our previous studies have…”
Get full text

Spatial Transcriptomics of Human Postmortem Brain Tissue Uncovers Molecular Pathways Associated with Amyloid‐Beta Plaques by Avey, Denis, Ng, Bernard, Iatrou, Artemis, Vialle, Ricardo A, Lopes, Katia de Paiva, Tasaki, Shinya, Xu, Jishu, De Tissera, Sashini L, Flood, Daniel, Bennett, David A. A, Wang, Yanling

“…Background Alzheimer’s disease (AD) pathologies include extracellular amyloid‐beta (A‐beta) plaques, intracellular neurofibrillary tangles, neuronal cell loss,…”
Get full text

Phosphoproteomic Analysis of KSHV-Infected Cells Reveals Roles of ORF45-Activated RSK during Lytic Replication: e1004993 by Avey, Denis, Tepper, Sarah, Li, Wenwei, Turpin, Zachary, Zhu, Fanxiu

“…Kaposi's Sarcoma-Associated Herpesvirus (KSHV) is an oncogenic virus which has adapted unique mechanisms to modulate the cellular microenvironment of its human…”
Get full text

Correction for Avey et al., "Discovery of a Coregulatory Interaction between Kaposi's Sarcoma-Associated Herpesvirus ORF45 and the Viral Protein Kinase ORF36" by Avey, Denis, Tepper, Sarah, Pifer, Benjamin, Bahga, Amritpal, Williams, Hunter, Gillen, Joseph, Li, Wenwei, Ogden, Sarah, Zhu, Fanxiu

Get full text