Search Results - "Avery, Kendra N"

Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies by Donaldson, Joshua M., Zer, Cindy, Avery, Kendra N., Bzymek, Krzysztof P., Horne, David A., Williams, John C.

“…Capitalizing on their extraordinary specificity, monoclonal antibodies (mAbs) have become one of the most reengineered classes of biological molecules. A major…”
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Mechanically interlocked functionalization of monoclonal antibodies by Bzymek, Krzysztof P., Puckett, James W., Zer, Cindy, Xie, Jun, Ma, Yuelong, King, Jeremy D., Goodstein, Leah H., Avery, Kendra N., Colcher, David, Singh, Gagandeep, Horne, David A., Williams, John C.

“…Because monoclonal antibodies (mAbs) have exceptional specificity and favorable pharmacology, substantial efforts have been made to functionalize them, either…”
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Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy by Yadav, Rajbharan, Schubbert, Suzanne, Holder, Patrick G, Chiang, Eugene Y, Kiabi, Nargess, Bogaert, Liz, Leung, Irene, Rashid, Rumana, Avery, Kendra N, Bonzon, Christine, Desjarlais, John R, Sanjabi, Shomyseh, Sharma, Amy, Lepherd, Michelle, Shelton, Amy, Chan, Pam, Liu, Yanqiu, Joslyn, Louis, Hosseini, Iraj, Stefanich, Eric G, Kamath, Amrita V, Bernett, Matthew J, Shivva, Vittal

“…Interleukin 15 (IL-15) is a potential anticancer agent and numerous engineered IL-15 agonists are currently under clinical investigation. Selective targeting…”
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M13 Bacteriophage as a Biological Scaffold for Magnetically-Recoverable Metal Nanowire Catalysts: Combining Specific and Nonspecific Interactions To Design Multifunctional Nanocomposites by Avery, Kendra N, Schaak, Janell E, Schaak, Raymond E

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Using quantitative single molecule localization microscopy to optimize multivalent HER2-targeting ligands by Wakefield, Devin L, Golfetto, Ottavia, Jorand, Raphael, Biswas, Sunetra, Meyer, Kassondra, Avery, Kendra N, Zer, Cindy, Cacao, Eliedonna E, Tobin, Steven J, Talisman, Ian J, Williams, John C, Jovanovic-Talisman, Tijana

“…The progression-free survival of patients with HER2-positive metastatic breast cancer is significantly extended by a combination of two monoclonal antibodies,…”
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Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells by Küçük, Can, Jiang, Bei, Hu, Xiaozhou, Zhang, Wenyan, Chan, John K. C., Xiao, Wenming, Lack, Nathan, Alkan, Can, Williams, John C., Avery, Kendra N., Kavak, Pınar, Scuto, Anna, Sen, Emel, Gaulard, Philippe, Staudt, Lou, Iqbal, Javeed, Zhang, Weiwei, Cornish, Adam, Gong, Qiang, Yang, Qunpei, Sun, Hong, d’Amore, Francesco, Leppä, Sirpa, Liu, Weiping, Fu, Kai, de Leval, Laurence, McKeithan, Timothy, Chan, Wing C.

“…Lymphomas arising from NK or γδ-T cells are very aggressive diseases and little is known regarding their pathogenesis. Here we report frequent activating…”
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A Platform To Enhance Quantitative Single Molecule Localization Microscopy by Golfetto, Ottavia, Wakefield, Devin L, Cacao, Eliedonna E, Avery, Kendra N, Kenyon, Victor, Jorand, Raphael, Tobin, Steven J, Biswas, Sunetra, Gutierrez, Jennifer, Clinton, Ronald, Ma, Yuelong, Horne, David A, Williams, John C, Jovanović-Talisman, Tijana

“…Quantitative single molecule localization microscopy (qSMLM) is a powerful approach to study in situ protein organization. However, uncertainty regarding the…”
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Engineering a high-affinity peptide binding site into the anti-CEA mAb M5A by Zer, Cindy, Avery, Kendra N., Meyer, Kassondra, Goodstein, Leah, Bzymek, Krzysztof P., Singh, Gagandeep, Williams, John C.

“…Abstract We have previously identified a cyclic peptide called meditope which binds to the central cavity of the Fab portion of cetuximab and shown that this…”
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Development of a High Affinity, Non-covalent Biologic to Add Functionality to Fabs by Avery, Kendra N., Zer, Cindy, Bzymek, Krzysztof P., Williams, John C.

“…Functionalization of monoclonal antibodies (mAbs) requires chemical derivatization and/or genetic manipulation. Inherent in these methods are challenges with…”
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1060 Optimally engineered IL18 Fc-fusion proteins balance potency and pharmacokinetics to promote strong anti-tumor activity by Nisthal, Alex, Lee, Sung-Hyung, Bonzon, Christine, Love, Ruschelle, Avery, Kendra N, Rashid, Rumana, Lertkiatmongkol, Panida, Rodriguez, Nicole, Leung, Irene, Karki, Sher, Barlow, Norman J, Chu, Seung Y, Moore, Gregory L, Desjarlais, John R

“…BackgroundInterleukin-18 (IL18) promotes expansion, survival, and cytotoxicity of T and NK cells. Tumor-experienced T cells upregulate the heterodimeric IL18…”
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1193 Synergistic targeting of multiple activating pathways with natural killer cell engagers by Zhang, Tian, Faber, Matthew S, Pong, Erik, Liu, Ke, Kim, Nahee, Bernett, Matthew J, Bonzon, Christine, Wieler, James, Diaz, Juan E, Avery, Kendra N, Henderson, Elizabeth, Yeh, William Y, Qi, Jing, Hao, Su-Shin, Rashid, Rumana, Bahjat, Rena, Desjarlais, John R, Bykova, Katrina

“…BackgroundTumor microenvironment induced antigens present a unique opportunity to effectively target diseased tissue over normal and to modulate the immune…”
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Meditope–Fab interaction: threading the hole by Bzymek, Krzysztof P., Ma, Yuelong, Avery, Kendra N., Horne, David A., Williams, John C.

“…Meditope, a cyclic 12‐residue peptide, binds to a unique binding side between the light and heavy chains of the cetuximab Fab. In an effort to improve the…”
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Abstract 1831: Affinity tuned XmAb®2+1 GPC3 x CD3 bispecific antibodies demonstrate selective activity in liver cancer models by Nisthal, Alex, Hassanzadeh-Kiabi, Nargess, Avery, Kendra N., Rashid, Rumana, Diaz, Juan E., Muchhal, Umesh S., Chu, Seung Y., Moore, Gregory L., Bykova, Katrina, Desjarlais, John R.

“…Abstract Bispecific T cell engagers simultaneously bind CD3 on T cells and tumor-associated antigens to promote T cell-mediated killing of tumor cells. These…”
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Abstract 5654: Affinity tuned Xmab®2+1 anti-mesothelin x anti-CD3 bispecific antibody induces selective T cell-dependent cellular cytotoxicity of human ovarian cancer cells by Zeng, Veronica G., Faber, Matthew S., Bernett, Matthew J., Avery, Kendra N., Zeytounian, John L., Rashid, Rumana, Muchhal, Umesh S., Moore, Gregory L., Desjarlais, John R., Hedvat, Michael

“…Abstract Mesothelin (MSLN) is a tumor-associated antigen highly expressed in ovarian tumors. Current treatment options for ovarian cancer have only modest…”
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Abstract 1880: PDL1-targeted CD28 costimulatory bispecific antibodies enhance T cell activation in solid tumors by Moore, Gregory L., Zeng, Veronica, Diaz, Juan, Bonzon, Christine, Avery, Kendra N., Love, Ruschelle, Dragovich, Matthew, Rashid, Rumana, Hackett, Michael, Leung, Irene W., Qi, Jing, Bakhit, Charles G., Muchhal, Umesh S., Barlow, Norman J., Desjarlais, John R., Hedvat, Michael

“…Abstract T cells in the tumor micro-environment require TCR/MHC engagement and co-stimulatory receptor engagement to achieve complete activation. Tumor cells…”
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Abstract 2286: XmAb30819, an XmAb®2+1 ENPP3 x CD3 bispecific antibody for RCC, demonstrates safety and efficacy in in vivo preclinical studies by Nisthal, Alex, Lee, Sung-Hyung, Kim, Yoon Kyung, Bonzon, Christine, Rashid, Rumana, Avery, Kendra N., Bogaert, Liz, Ardila, Connie, Leung, Irene W., Rodriguez, Nicole, Muchhal, Umesh S., Moore, Gregory L., Chu, Seung Y., Desjarlais, John R.

“…Abstract Bispecific T cell engagers simultaneously bind CD3 on T cells and tumor-associated antigens to promote T cell-mediated killing of tumor cells. While…”
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Abstract 1860: Bispecific claudin-6 x CD3 antibodies in a 2 + 1 format demonstrate selectivity and activity on human ovarian cancer cells by Faber, Matthew S., Lee, Sung-Hyung, Kim, Yoon Kyung, Qi, Jing, Avery, Kendra N., Nguyen, Duc-Hanh T., Rashid, Rumana, Eivazi, Araz, Chu, Seung Y., Diaz, Juan E., Ardila, Connie, Love, Ruschelle, Nisthal, Alex, Barlow, Norman J., Bonzon, Christine, Muchhal, Umesh S., Bernett, Matthew J., Desjarlais, John R.

“…Abstract There is a large unmet need for targeted therapies to treat ovarian cancer and other solid tumors. A promising strategy is the use of T cell engaging…”
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Abstract 2962: ASP2138, a novel 2+1 format, claudin 18.2 x CD3 bispecific antibody, demonstrates selectivity and activity in preclinical cancer models by Nakazawa, Taisuke, Tanaka, Hiroaki, Kikuchi, Aya, Rashid, Rumana, Avery, Kendra N., Qi, Jing, Nisthal, Alex, Shimazaki, Masashi, Shirasuna, Kenna

“…Abstract Claudin 18.2 (CLDN18.2) is a member of the claudin family of proteins that are involved in the formation of tight junctions in epithelia and…”
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Abstract 1595: IL15/IL15Rα heterodimeric Fc-fusions with extended half-lives by Bernett, Matthew J., Bonzon, Christine, Rashid, Rumana, Varma, Rajat, Avery, Kendra N., Leung, Irene W., Chu, Seung Y., Muchhal, Umesh S., Moore, Gregory L., Desjarlais, John R.

“…Abstract IL15 and IL2 are similar cytokines that stimulate the proliferation and differentiation of B cells, T cells, and NK cells. Both cytokines exert their…”
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Abstract 5565: Potency-reduced IL15/IL15Rα heterodimeric Fc-fusions display enhanced in vivo activity through increased exposure by Bernett, Matthew J., Varma, Rajat, Bonzon, Christine, Rashid, Rumana, Bogaert, Liz, Liu, Ke, Schubbert, Suzanne, Avery, Kendra N., Leung, Irene W., Rodriguez, Nicole, Chu, Seung Y., Muchhal, Umesh S., Moore, Gregory L., Desjarlais, John R.

“…Abstract IL15 and IL2 are two similar cytokines that stimulate the proliferation of lymphocytes, and their therapeutic potential has been well established in…”
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