Search Results - "Aversa, Robert J"

Continuing Saga of the Marine Polyether Biotoxins by Nicolaou, K.C, Frederick, Michael O, Aversa, Robert J

“…The unprecedented structure of the marine natural product brevetoxin B was elucidated by the research group of Nakanishi and Clardy in 1981. The ladderlike…”
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Synthesis of the ABCDEFG Ring System of Maitotoxin by Nicolaou, K. C, Aversa, Robert J, Jin, Jian, Rivas, Fatima

“…Maitotoxin (1) continues to fascinate scientists not only because of its size and potent neurotoxicity but also due to its molecular architecture. To provide…”
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Synthesis of the C′D′E′F′ Domain of Maitotoxin by Nicolaou, K. C, Seo, Jae Hong, Nakamura, Tsuyoshi, Aversa, Robert J

“…A devised biomimetic strategy toward the C′D′E′F′ domain (6) of maitotoxin (1) led to hydroxy triepoxide 8 as a postulated polyepoxide precursor. However, all…”
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Chemical Synthesis of the GHIJK Ring System and Further Experimental Support for the Originally Assigned Structure of Maitotoxin by Nicolaou, K.C, Cole, Kevin P, Frederick, Michael O, Aversa, Robert J, Denton, Ross M

“…Accepting the proposal: The originally proposed structure of maitotoxin has recently come under scrutiny based on biosynthetic and computational…”
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Chemical Synthesis of the GHIJKLMNO Ring System of Maitotoxin by Nicolaou, K. C, Frederick, Michael O, Burtoloso, Antonio C. B, Denton, Ross M, Rivas, Fatima, Cole, Kevin P, Aversa, Robert J, Gibe, Romelo, Umezawa, Taiki, Suzuki, Takahiro

“…As the largest secondary metabolite to be discovered as of yet, the polyether marine neurotoxin maitotoxin constitutes a major structural and synthetic…”
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Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5‑a]pyrazines as ATR Inhibitors by Barsanti, Paul A, Aversa, Robert J, Jin, Xianming, Pan, Yue, Lu, Yipin, Elling, Robert, Jain, Rama, Knapp, Mark, Lan, Jiong, Lin, Xiaodong, Rudewicz, Patrick, Sim, Janet, Taricani, Lorena, Thomas, George, Xiao, Linda, Yue, Qin

“…A saturation strategy focused on improving the selectivity and physicochemical properties of ATR inhibitor HTS hit 1 led to a novel series of highly potent and…”
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Maitotoxin: An Inspiration for Synthesis by Nicolaou, K. C., Aversa, Robert J.

“…Maitotoxin holds a special place in the annals of natural products chemistry as the largest and most toxic secondary metabolite known to date. Its fascinating,…”
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Design and Discovery of N‑(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic by Ramurthy, Savithri, Taft, Benjamin R, Aversa, Robert J, Barsanti, Paul A, Burger, Matthew T, Lou, Yan, Nishiguchi, Gisele A, Rico, Alice, Setti, Lina, Smith, Aaron, Subramanian, Sharadha, Tamez, Victoriano, Tanner, Huw, Wan, Lifeng, Hu, Cheng, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Tellew, John E, Huang, Shenlin, Yue, Qin, Chaudhary, Apurva, Tian, Hung, Iyer, Raman, Hassan, A. Quamrul, Mathews Griner, Lesley A, La Bonte, Laura R, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Mishina, Yuji, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Sellers, William R, Lees, Emma, Shao, Wenlin, Dillon, Michael P, Stuart, Darrin D

“…Direct pharmacological inhibition of RAS has remained elusive, and efforts to target CRAF have been challenging due to the complex nature of RAF signaling,…”
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Design and Discovery of N‑(2-Methyl-5′-morpholino-6′-((tetrahydro‑2H‑pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers by Nishiguchi, Gisele A, Rico, Alice, Tanner, Huw, Aversa, Robert J, Taft, Benjamin R, Subramanian, Sharadha, Setti, Lina, Burger, Matthew T, Wan, Lifeng, Tamez, Victoriano, Smith, Aaron, Lou, Yan, Barsanti, Paul A, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Dix, Ina, Tellew, John E, Huang, Shenlin, Mathews Griner, Lesley A, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Ma, Sylvia, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Jansen, Johanna M, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Lees, Emma, Shao, Wenlin, Stuart, Darrin D, Dillon, Michael P, Ramurthy, Savithri

“…RAS oncogenes have been implicated in >30% of human cancers, all representing high unmet medical need. The exquisite dependency on CRAF kinase in KRAS mutant…”
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Synthesis of the C'D'E'F' domain of maitotoxin by Nicolaou, K C, Seo, Jae Hong, Nakamura, Tsuyoshi, Aversa, Robert J

“…A devised biomimetic strategy toward the C'D'E'F' domain (6) of maitotoxin (1) led to hydroxy triepoxide 8 as a postulated polyepoxide precursor. However, all…”
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Structure-Based Drug Design of Novel, Potent, and Selective Azabenzimidazoles (ABI) as ATR Inhibitors by Barsanti, Paul A, Pan, Yue, Lu, Yipin, Jain, Rama, Cox, Matthew, Aversa, Robert J, Dillon, Michael P, Elling, Robert, Hu, Cheng, Jin, Xianming, Knapp, Mark, Lan, Jiong, Ramurthy, Savithri, Rudewicz, Patrick, Setti, Lina, Subramanian, Sharadha, Mathur, Michelle, Taricani, Lorena, Thomas, George, Xiao, Linda, Yue, Qin

“…Compound 13 was discovered through morphing of the ATR biochemical HTS hit 1. The ABI series was potent and selective for ATR. Incorporation of a 6-azaindole…”
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Cover Picture: Maitotoxin: An Inspiration for Synthesis (Isr. J. Chem. 3-4/2011) by Nicolaou, K. C., Aversa, Robert J.

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Chemical Synthesis of the GHIJK Ring System and Further Experimental Support for the Originally Assigned Structure of Maitotoxin by Nicolaou, K. C., Cole, Kevin P., Frederick, Michael O., Aversa, Robert J., Denton, Ross M.

“…Bestätigung für einen Vorschlag: Die ursprünglich vorgeschlagene Struktur von Maitotoxin wurde kürzlich durch Erwägungen zur Biosynthese und Rechnungen infrage…”
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Cover Picture: The Continuing Saga of the Marine Polyether Biotoxins (Angew. Chem. Int. Ed. 38/2008) by Nicolaou, K. C., Frederick, Michael O., Aversa, Robert J.

“…An odyssey is described by K. C. Nicolaou et al. in their Review on page 7182 ff.: From the isolation of the first marine biotoxin with a ladder structure,…”
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Titelbild: Die Entdeckung und Synthese von marinen Polyethern (Angew. Chem. 38/2008) by Nicolaou, K. C., Frederick, Michael O., Aversa, Robert J.

“…Eine Odyssee erzählen K. C. Nicolaou et al. in ihrem Aufsatz auf S. 7292 ff. nach: Von der Isolierung von Brevetoxin B, dem ersten marinen Biotoxin mit…”
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Die Entdeckung und Synthese von marinen Polyethern by Nicolaou, K. C., Frederick, Michael O., Aversa, Robert J.

“…Die beispiellose Struktur des marinen Naturstoffs Brevetoxin B wurde 1981 von den Arbeitsgruppen um Nakanishi und Clardy aufgeklärt. Das leiterförmige…”
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Titelbild: Die Entdeckung und Synthese von marinen Polyethern (Angew. Chem. 38/2008) by Nicolaou, K. C., Frederick, Michael O., Aversa, Robert J.

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