Haemophilia A (factor VIII deficiency) in a litter of Weimaraners

Inherited coagulopathies are reported in a number of dog breeds. However, to date, there is no report of Weimaraners suffering factor VIII deficiency (haemophilia A). We report the discovery of haemophilia A in both males from a single litter of Weimaraners. Haemophilia A in human beings often resul...

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Bibliographic Details
Published in:	Journal of small animal practice Vol. 50; no. 7; pp. 357 - 359
Main Authors:	Dunning, M.D, Averis, G.F, Pattinson, H, Targett, M, Cade, S, Herrtage, M.E
Format:	Journal Article
Language:	English
Published:	Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01-07-2009 Blackwell Publishing Ltd
Subjects:	Animals blood coagulation factors dog breeds dog diseases Dog Diseases - genetics Dogs factor VIII Factor VIII - genetics genetic disorders Genetic Predisposition to Disease hemophilia Hemophilia A - genetics Hemophilia A - veterinary inheritance (genetics) litters (young animals) Male males Mutation Pedigree puppies screening stochastic mutation Weimaraner (dog breed)
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Summary:	Inherited coagulopathies are reported in a number of dog breeds. However, to date, there is no report of Weimaraners suffering factor VIII deficiency (haemophilia A). We report the discovery of haemophilia A in both males from a single litter of Weimaraners. Haemophilia A in human beings often results from a de novo stochastic mutation. We found no evidence using currently available screening tests of haemophilia A in relatives as far back as three generations making a stochastic mutation possible in this litter.
Bibliography:	http://dx.doi.org/10.1111/j.1748-5827.2009.00727.x ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0022-4510 1748-5827
DOI:	10.1111/j.1748-5827.2009.00727.x