Search Results - "Averill, Jameson R"

Mutagenic incorporation of inosine into DNA via T:I mismatch formation by human DNA polymerase eta (polη) by Averill, Jameson R, Jung, Hunmin

“…Inosine is a key intermediate in de novo purine nucleotide biosynthesis in cells. Inosine is known to be mutagenic when it is present in DNA, in place of…”
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Novel insights into the role of translesion synthesis polymerase in DNA incorporation and bypass of 5-fluorouracil in colorectal cancer by Averill, Jameson R, Lin, Jackson C, Jung, John, Jung, Hunmin

“…5-Fluorouracil (5-FU) is the first-line chemotherapeutic agent in colorectal cancer, and resistance to 5-FU easily emerges. One of the mechanisms of drug…”
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