Production of Vitamin B2 (Riboflavin) by Microorganisms: An Overview

Riboflavin is a crucial micronutrient that is a precursor to coenzymes flavin mononucleotide and flavin adenine dinucleotide, and it is required for biochemical reactions in all living cells. For decades, one of the most important applications of riboflavin has been its global use as an animal and h...

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Bibliographic Details
Published in:	Frontiers in bioengineering and biotechnology Vol. 8
Main Authors:	Averianova, Liudmila A., Balabanova, Larissa A., Son, Oksana M., Podvolotskaya, Anna B., Tekutyeva, Liudmila A.
Format:	Journal Article
Language:	English
Published:	Frontiers Media S.A 12-11-2020
Subjects:	Bioengineering and Biotechnology food/feed additive genetically modified microorganisms metabolic engineering riboflavin vitamin B2
Online Access:	Get full text
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Summary:	Riboflavin is a crucial micronutrient that is a precursor to coenzymes flavin mononucleotide and flavin adenine dinucleotide, and it is required for biochemical reactions in all living cells. For decades, one of the most important applications of riboflavin has been its global use as an animal and human nutritional supplement. Being well-informed of the latest research on riboflavin production via the fermentation process is necessary for the development of new and improved microbial strains using biotechnology and metabolic engineering techniques to increase vitamin B2 yield. In this review, we describe well-known industrial microbial producers, namely, Ashbya gossypii , Bacillus subtilis , and Candida spp. and summarize their biosynthetic pathway optimizations through genetic and metabolic engineering, combined with random chemical mutagenesis and rational medium components to increase riboflavin production.
Bibliography:	Edited by: Chettiyappan Visvanathan, Asian Institute of Technology, Thailand Reviewed by: Xiaowei Li, Chalmers University of Technology, Sweden; Shepo Shi, Beijing University of Chinese Medicine, China This article was submitted to Industrial Biotechnology, a section of the journal Frontiers in Bioengineering and Biotechnology
ISSN:	2296-4185 2296-4185
DOI:	10.3389/fbioe.2020.570828