Search Results - "Averbukh, Edward"
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Central Serous Chorioretinopathy Development following Cessation of Terbinafine Treatment
Published in Case reports in ophthalmology (27-10-2022)“…This report describes a case of central serous chorioretinopathy (CSCR) occurring following cessation of terbinafine treatment. A 51-year-old man presented for…”
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Six Years and Counting: Restoration of Photopic Retinal Function and Visual Behavior Following Gene Augmentation Therapy in a Sheep Model of CNGA3 Achromatopsia
Published in Human gene therapy (01-12-2018)“…Achromatopsia causes severely reduced visual acuity, photoaversion, and inability to discern colors due to cone photoreceptor dysfunction. In 2010, we reported…”
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Endogenous fungal endophthalmitis: risk factors, clinical course, and visual outcome in 13 patients
Published in International journal of ophthalmology (18-01-2021)“…To analyze the risk factors, ophthalmological features, treatment modalities and their effect on the visual outcome in patients with endogenous fungal…”
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Cortical Visual Mapping following Ocular Gene Augmentation Therapy for Achromatopsia
Published in The Journal of neuroscience (01-09-2021)“…The ability of the adult human brain to develop function following correction of congenital deafferentation is controversial. Specifically, cases of recovery…”
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Characterization of anti-AAV2 neutralizing antibody levels in sheep prior to and following intravitreal AAV2.7m8 injection
Published in Gene therapy (29-10-2024)“…Gene augmentation therapy is a promising treatment for incurable, blinding inherited retinal diseases, and intravitreal delivery is being studied as a safe…”
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Gene Augmentation Therapy Restores Retinal Function and Visual Behavior in a Sheep Model of CNGA3 Achromatopsia
Published in Molecular therapy (01-09-2015)“…Achromatopsia is a hereditary form of day blindness caused by cone photoreceptor dysfunction. Affected patients suffer from congenital color blindness,…”
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Correlation of Response between Both Eyes to First- and Second-Line Anti-VEGF Therapy in Diabetic Macular Edema
Published in Current eye research (03-04-2021)“…To evaluate the anatomical correlation between fellow eyes for bilateral second-line anti-VEGF treatment in eyes with bilateral diabetic macular edema (DME)…”
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PERSISTENT LOCULATED SUBRETINAL FLUID AFTER RHEGMATOGENOUS RETINAL DETACHMENT SURGERY
Published in Retina (Philadelphia, Pa.) (01-06-2020)“…To identify factors associated with persistent subretinal fluid (SRF) after small-gauge pars plana vitrectomy for primary rhegmatogenous retinal detachment…”
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Socioeconomic status and visual outcome in patients with neovascular age-related macular degeneration
Published in European journal of ophthalmology (01-05-2021)“…Purpose Visual outcome in patients with neovascular age-related macular degeneration is variable. We aimed to evaluate for association between socioeconomic…”
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Advanced Optical Analysis of Divergence Between the Foci of the Neodymium-Doped Yttrium Aluminum Garnet (Nd:YAG) and Aiming Beam Lasers
Published in Ophthalmology science (Online) (01-09-2024)“…To evaluate the divergence between the neodymium-doped yttrium aluminum garnet (Nd:YAG) surgical laser and the aiming diode laser beams foci. Optical analysis…”
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Characterising the phenotype and progression of sporadic adult-onset foveomacular vitelliform dystrophy
Published in British journal of ophthalmology (01-11-2016)“…Adult-onset foveomacular vitelliform dystrophy (AFVD) is a relatively common macular degeneration which might lead to substantial visual loss. Our purpose was…”
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Gene Augmentation Therapy for a Missense Substitution in the cGMP-Binding Domain of Ovine CNGA3 Gene Restores Vision in Day-Blind Sheep
Published in Investigative ophthalmology & visual science (01-03-2017)“…Applying CNGA3 gene augmentation therapy to cure a novel causative mutation underlying achromatopsia (ACHM) in sheep. Impaired vision that spontaneously…”
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Naturally-occurring myopia and loss of cone function in a sheep model of achromatopsia
Published in Scientific reports (09-11-2020)“…Achromatopsia is an inherited retinal disease characterized by loss of cone photoreceptor function. Day blind CNGA3 mutant Improved Awassi sheep provide a…”
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Consecutive unilateral recording of the two eyes affects dark-adapted ERG responses, when compared to simultaneous bilateral recording
Published in Documenta ophthalmologica (01-12-2018)“…Purpose Our aim was to compare the electroretinographic (ERG) responses of two eyes obtained by consecutive unilateral recordings to those obtained by a…”
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Evaluation of the association of single nucleotide polymorphisms in the PRPH2 gene with adult-onset foveomacular vitelliform dystrophy
Published in Ophthalmic genetics (01-09-2016)“…A minority of patients with adult-onset foveomacular vitelliform dystrophy (AFVD) carry mutations in the PRPH2 gene. This gene is highly polymorphic and it was…”
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Flicker cone function in normal and day blind sheep: a large animal model for human achromatopsia caused by CNGA3 mutation
Published in Documenta ophthalmologica (01-12-2014)“…Purpose Recently we reported on day blindness in sheep caused by a mutation in the CNGA3 gene, thus making affected sheep a naturally occurring large animal…”
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Bevacizumab treatment for neovascular age-related macular degeneration in the setting of a clinic: "real life" long-term outcome
Published in BMC ophthalmology (11-04-2015)“…To evaluate the long-term outcome of bevacizumab therapy for neovascular age related macular degeneration (NVAMD) in the setting of a clinic. Consecutive group…”
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Safety and Efficacy Evaluation of rAAV2tYF-PR1.7-hCNGA3 Vector Delivered by Subretinal Injection in CNGA3 Mutant Achromatopsia Sheep
Published in Human gene therapy. Clinical development (01-06-2017)“…Applied Genetic Technologies Corporation (AGTC) is developing a recombinant adeno-associated virus (rAAV) vector expressing the human CNGA3 gene designated…”
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A novel day blindness in sheep: Epidemiological, behavioural, electrophysiological and histopathological studies
Published in The veterinary journal (1997) (01-08-2010)“…Four genetically related Improved Awassi sheep flocks had sporadic births of lambs with congenital visual impairments that differed from other known forms of…”
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Bevacizumab for choroidal neovascularization related to inflammatory diseases
Published in Retina (Philadelphia, Pa.) (01-06-2010)“…The purpose of this study was to report our experience with intravitreal bevacizumab for inflammation-related choroidal neovascularization in two tertiary…”
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