Search Results - "Avagyan, Serine"

Lessons From Pediatric MDS: Approaches to Germline Predisposition to Hematologic Malignancies by Avagyan, Serine, Shimamura, Akiko

“…Pediatric myelodysplastic syndromes (MDS) often raise concern for an underlying germline predisposition to hematologic malignancies, referred to as germline…”
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Editorial: Biological aspects of bone marrow failure by Diamantopoulos, Panagiotis, Avagyan, Serine, Solomou, Elena

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ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation by Yvan-Charvet, Laurent, Pagler, Tamara, Gautier, Emmanuel L., Avagyan, Serine, Siry, Read L., Han, Seongah, Welch, Carrie L., Wang, Nan, Randolph, Gwendalyn J., Snoeck, Hans W., Tall, Alan R.

“…Elevated leukocyte cell numbers (leukocytosis), and monocytes in particular, promote atherosclerosis; however, how they become increased is poorly understood…”
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Prdm16 is a physiologic regulator of hematopoietic stem cells by Aguilo, Francesca, Avagyan, Serine, Labar, Amy, Sevilla, Ana, Lee, Dung-Fang, Kumar, Parameet, Lemischka, Ihor R., Zhou, Betty Y., Snoeck, Hans-Willem

“…Fetal liver and adult bone marrow hematopoietic stem cells (HSCs) renew or differentiate into committed progenitors to generate all blood cells. PRDM16 is…”
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Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C by Binder, Vera, Li, Wantong, Faisal, Muhammad, Oyman, Konur, Calkins, Donn L., Shaffer, Jami, Teets, Emily M., Sher, Steven, Magnotte, Andrew, Belardo, Alex, Deruelle, William, Gregory, T. Charles, Orwick, Shelley, Hagedorn, Elliott J., Perlin, Julie R., Avagyan, Serine, Lichtig, Asher, Barrett, Francesca, Ammerman, Michelle, Yang, Song, Zhou, Yi, Carson, William E., Shive, Heather R., Blachly, James S., Lapalombella, Rosa, Zon, Leonard I., Blaser, Bradley W.

“…Altered hematopoietic stem cell (HSC) fate underlies primary blood disorders but microenvironmental factors controlling this are poorly understood. Genetically…”
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Quantitative trait mapping reveals a regulatory axis involving peroxisome proliferator-activated receptors, PRDM16, transforming growth factor-β2 and FLT3 in hematopoiesis by Avagyan, Serine, Aguilo, Francesca, Kamezaki, Kenjiro, Snoeck, Hans-Willem

“…Hematopoiesis is the process whereby BM HSCs renew to maintain their number or to differentiate into committed progenitors to generate all blood cells. One…”
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Clonal hematopoiesis and inflammation – the perpetual cycle by Avagyan, Serine, Zon, Leonard I.

“…Clonal hematopoiesis (CH) is associated with elevated pro-inflammatory cytokines which act as a driving force for clonal expansion.Recurrent or chronic…”
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Asxl1-mutant Dominant Clones Have an Erythropoietic Lineage Deficiency through a Disturbed Epigenetic Landscape by Avagyan, Serine, Yang, Song, Gheller, Brandon, Zon, Leonard I.

“…Two hematologic features of red blood cells (RBCs) rank among the top three high risk factors associated with increased risk of malignant progression from…”
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To T or not to B: germline RUNX1 mutation preferences in pediatric ALL predisposition by Avagyan, Serine, Brown, Anna L

“…Germline RUNX1 variants have been identified in relation to myeloid malignancy predisposition, with lymphoid hematological malignancies present at a lower…”
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2023 – CELLULAR BARCODING OF THE LEUKEMIC NICHE REVEALS AN APELIN-MEDIATED CLONAL EXPANSION OF NICHE ENDOTHELIAL AND MESENCHYMAL STROMAL CELLS by Baron, Chloé, Avagyan, Serine, Yang, Song, McKenna, Aaron, Zon, Leonard

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Fish to Learn: Insights into Blood Development and Blood Disorders from Zebrafish Hematopoiesis by Avagyan, Serine, Zon, Leonard I

“…Since its introduction in early 1980s, the zebrafish (Danio rerio) has become an invaluable vertebrate animal model system to study many human disorders in…”
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3009 – APELIN-MEDIATED CLONAL EXPANSION OF NICHE ENDOTHELIAL CELLS DRIVES SELECTION OF LEUKEMIC AND NORMAL HSC CLONES by Baron, Chloé, Avagyan, Serine, Mitchell, Olivia, Yang, Song, Mckenna, Aaron, Zon, Leonard

“…Hematopoietic stem and progenitor cells (HSPCs) reside in niches that provide regulatory signals for their function. HSPC clones have been examined by cellular…”
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Effect of enforced expression of cxcl8 by hematopoietic stem and progenitor cells on niche interactions and hematopoietic progenitor cells in adult zebrafish by Blaser, Bradley Wayne, Avagyan, Serine, Zon, Leonard

“…Abstract only…”
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Visualizing Clonal Hematopoiesis Associated with gata2 Deficiency in Zebrafish Using Color-Barcoding by Avagyan, Serine, Mannherz, William, Zon, Leonard I.

“…Myeloid neoplasms, such as myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), arise from abnormal hematopoietic stem and progenitor cells…”
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Early Clonal Hematopoiesis Detected in Gata2 heterozygosity By Color-Barcoding of Hematopoietic Stem Cells in Zebrafish by Avagyan, Serine, Mannherz, William P., Zon, Leonard I.

“…Germline GATA2 haploinsufficiency underlies an inherited syndrome of predisposition to myeloid malignancies. The mechanism by which GATA2 mutations lead to…”
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Loss of nr4a1 abrogates Fitness of asxl1-mutant Hematopoietic Clones by Avagyan, Serine, Henninger, Jonathan E, Mannherz, William P., Mistry, Meeta, Yang, Song, Weber, Margaret C., Moore, Jessica, Zon, Leonard I.

“…Clonal fitness of mutant hematopoietic stem and progenitor cells (HSPCs) underlies clonal hematopoiesis (CH), a state of clonal expansion associated with…”
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Understanding the regulation of vertebrate hematopoiesis and blood disorders – big lessons from a small fish by Robertson, Anne L., Avagyan, Serine, Gansner, John M., Zon, Leonard I.

“…Hematopoietic stem cells (HSCs) give rise to all differentiated blood cells. Understanding the mechanisms that regulate self‐renewal and lineage specification…”
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P23-031-23 Inhibition of Choline-Phospholipid Metabolism Prevents Clonal Hematopoiesis Progression by Gheller, Brandon, Avagyan, Serine, Gopakumar, Jayakrishnan, Jaiswal, Siddhartha, Zon, Leonard

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Mosaic Mutagenesis In Vivo Reveals Mutant Blood Stem Cells Intrinsically Resistant to Inflammatory Mediators in Clonal Hematopoiesis by Avagyan, Serine, Henninger, Jonathan E, Mannherz, William P., Mistry, Meeta, Yang, Song P., Weber, Margaret, Moore, Jessica, Zon, Leonard I.

“…Clonal hematopoiesis (CH) is a state of clonal dominance of a mutant hematopoietic stem and progenitor cell (HSPC) promoted by unknown mechanisms. To study the…”
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Cxcl8 Expands Hematopoietic Stem and Progenitor Cells and Alters Their Interaction with the Endothelial Niche by Calkins, Donn L, Shaffer, Jami L, Teets, Emily M, Belardo, Alex M, Avagyan, Serine, Zon, Leonard I, Blaser, Bradley W

“…We currently have little understanding of the mechanisms by which hematopoietic stem and progenitor cells (HSPCs) gain a selective advantage in patients with…”
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