Search Results - "Auton, Timothy R"

Randomized double-blind placebo-controlled study of an angiotensin immunotherapeutic vaccine (PMD3117) in hypertensive subjects by Brown, Morris J, Coltart, John, Gunewardena, Kulasiri, Ritter, James M, Auton, Timothy R, Glover, James F

“…Immunization against components of the renin-angiotensin system offers a potential alternative to daily medication in some patients with hypertension or heart…”
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Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes by Eldridge, M D, Murray, C W, Auton, T R, Paolini, G V, Mee, R P

“…This paper describes the development of a simple empirical scoring function designed to estimate the free energy of binding for a protein-ligand complex when…”
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Empirical scoring functions. II. The testing of an empirical scoring function for the prediction of ligand-receptor binding affinities and the use of Bayesian regression to improve the quality of the model by Murray, C W, Auton, T R, Eldridge, M D

“…This paper tests the performance of a simple empirical scoring function on a set of candidate designs produced by a de novo design package. The scoring…”
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PRO_SELECT: combining structure-based drug design and combinatorial chemistry for rapid lead discovery. 1. Technology by Murray, C W, Clark, D E, Auton, T R, Firth, M A, Li, J, Sykes, R A, Waszkowycz, B, Westhead, D R, Young, S C

“…This paper describes a novel methodology, PRO_SELECT, which combines elements of structure-based drug design and combinatorial chemistry to create a new…”
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Vehicle effects on in vitro percutaneous absorption through rat and human skin by HILTON, J, WOOLLEN, B. H, SCOTT, R. C, AUTON, T. R, TREBILCOCK, K. L, WILKS, M. F

“…We studied the effects of three vehicles (propylene glycol, octanol and ethyl decanoate) with differing polarity on the in vitro percutaneous absorption of…”
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Extended Summary: Design of active analogues of a peptide using D-optimal Design, QSAR models and a combinatorial search algorithm by Mee, Roger P., Auton, Timothy R., Eldridge, Matthew D., Brooks, Alan G.

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