Search Results - "Auton, T. R."

Evaluation of two carrier protein–angiotensin I conjugate vaccines to assess their future potential to control high blood pressure (hypertension) in man by Downham, M. R., Auton, T. R., Rosul, A., Sharp, H. L., Sjöström, L., Rushton, A., Richards, J. P., Mant, T. G. K., Gardiner, S. M., Bennett, T., Glover, J. F.

“…Aims  We aim to modulate the renin–angiotensin system (RAS) by active immunization against angiotensin I hormone (AI), potentially providing a novel conjugate…”
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From toxicological problem to therapeutic use: The discovery of the mode of action of 2‐(2‐nitro‐4‐trifluoromethylbenzoyl)‐1,3‐cyclohexanedione (NTBC), its toxicology and development as a drug by Lock, E. A., Ellis, M. K., Gaskin, P., Robinson, M., Auton, T. R., Provan, W. M., Smith, L. L., Prisbylla, M. P., Mutter, L. C., Lee, D. L.

“…NTBC is a triketone with herbicidal activity that has been shown to have a novel mode of action by inhibiting the enzyme 4‐hydroxyphenylpyruvate dioxygenase in…”
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Inhibition of 4-Hydroxyphenylpyruvate Dioxygenase by 2-(2-Nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione and 2-(2-Chloro-4-methanesulfonylbenzoyl)-cyclohexane-1,3-dione by Ellis, M.K., Whitfield, A.C., Gowans, L.A., Auton, T.R., Provan, W.M., Lock, E.A., Smith, L.L.

“…The administration of the compound 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane- 1,3-dione (NTBC) to rats(10 mg/ kg body wt) caused an elevation in the…”
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Thresholds in Chemical Carcinogenesis by Purchase, I.F.H., Auton, T.R.

“…It is common practice to base carcinogenic risk assessment on the view that there is no threshold for chemical carcinogenesis. In this context, the threshold…”
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Vehicle effects on in vitro percutaneous absorption through rat and human skin by HILTON, J, WOOLLEN, B. H, SCOTT, R. C, AUTON, T. R, TREBILCOCK, K. L, WILKS, M. F

“…We studied the effects of three vehicles (propylene glycol, octanol and ethyl decanoate) with differing polarity on the in vitro percutaneous absorption of…”
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Calculation of benchmark doses from teratology data by Auton, T R

“…The benchmark dose approach has several potential advantages over the no observed adverse effect level (NOAEL) as a basis for risk assessment of toxic…”
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Statistical comparison of established T-cell epitope predictors against a large database of human and murine antigens by Deavin, A.J., Auton, T.R., Greaney, P.J.

“…Identification of T-cell epitopes within a protein antigen is an important tool in vaccine design. The T-cell epitope prediction schemes often are exploited by…”
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A physiologically based mathematical model of dermal absorption in man by Auton, T R, Westhead, D R, Woollen, B H, Scott, R C, Wilks, M F

“…A sound understanding of the mechanisms determining percutaneous absorption is necessary for toxicological risk assessment of chemicals contacting the skin. As…”
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Application of benchmark dose risk assessment methodology to developmental toxicity: an industrial view by Foster, Paul M.D., Auton, Tim R.

“…The U.S. EPA first signalled its intention to use benchmark dose risk techniques in 1991. Subsequently, publication of draft Guidelines for the Risk Assessment…”
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Empirical scoring functions. II. The testing of an empirical scoring function for the prediction of ligand-receptor binding affinities and the use of Bayesian regression to improve the quality of the model by Murray, C W, Auton, T R, Eldridge, M D

“…This paper tests the performance of a simple empirical scoring function on a set of candidate designs produced by a de novo design package. The scoring…”
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Joint risk from multiple compound exposure by Auton, T R

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Retrospective appraisal of the relationship between skin irritancy and contact sensitization potential by Auton, T R, Botham, P A, Kimber, I

“…A retrospective analysis of the association between skin irritancy and the potential to cause contact sensitization has been performed employing a historical…”
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Pharmacokinetics of fluazifop-butyl in human volunteers. II: Dermal dosing by Ramsey, J D, Woollen, B H, Auton, T R, Batten, P L, Leeser, J E

“…1. The absorption of the herbicide fluazifop-butyl (f-b), has been determined from plasma and urine measurements in groups of six male volunteers following…”
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Concentration-flux relations for a multicellular biological membrane with metabolism by Auton, T R

“…A mathematical model is described for the simultaneous diffusion and metabolism of a chemical penetrating a multicellular biological membrane such as skin…”
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Human inhalation pharmacokinetics of 1,1,2-trichloro-1,2,2-trifluoroethane (FC113) by WOOLLEN, B. H, GUEST, E. A, HOWE, W, MARSH, J. R, WILSON, H. K, AUTON, T. R, BLAIN, P. G

“…Seven male volunteers were exposed to atmospheric concentrations of either 1980, 4100 or 7630 mg m-3 1,1,2-trichloro-1,2,2-trifluoroethane (FC113) for 4 h…”
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A physiologically based mathematical model for the human inhalation pharmacokinetics of 1,1,2-trichloro-1,2,2-trifluoroethane by AUTON, T. R, WOOLLEN, B. H

“…A physiologically based mathematical model is described for the human inhalation pharmacokinetics of 1,1,2-trichloro-1,2,2-trifluoroethane (FC113)…”
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Active immunization with angiotensin I peptide analogue vaccines selectively reduces the pressor effects of exogenous angiotensin I in conscious rats by Gardiner, S M, Auton, T R, Downham, M R, Sharp, H L, Kemp, P A, March, J E, Martin, H, Morgan, P J, Rushton, A, Bennett, T, Glover, J F

“…Male, Sprague‐Dawley rats were actively immunized with novel angiotensin vaccines, and their pressor responses to exogenous angiotensin I (AI) and angiotensin…”
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PRO_SELECT: combining structure-based drug design and combinatorial chemistry for rapid lead discovery. 1. Technology by Murray, C W, Clark, D E, Auton, T R, Firth, M A, Li, J, Sykes, R A, Waszkowycz, B, Westhead, D R, Young, S C

“…This paper describes a novel methodology, PRO_SELECT, which combines elements of structure-based drug design and combinatorial chemistry to create a new…”
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The predictive accuracy of in vitro measurements for the dermal absorption of a lipophilic penetrant (fluazifop-butyl) through rat and human skin by Ramsey, J D, Woollen, B H, Auton, T R, Scott, R C

“…The predictive accuracy of in vitro measurements in estimating dermal absorption has been evaluated in rat and human skin using fluazifop-butyl (FB), a…”
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Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes by Eldridge, M D, Murray, C W, Auton, T R, Paolini, G V, Mee, R P

“…This paper describes the development of a simple empirical scoring function designed to estimate the free energy of binding for a protein-ligand complex when…”
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