Search Results - "Autio, Kaija J."

Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology by Kastaniotis, Alexander J., Autio, Kaija J., Kerätär, Juha M., Monteuuis, Geoffray, Mäkelä, Anne M., Nair, Remya R., Pietikäinen, Laura P., Shvetsova, Antonina, Chen, Zhijun, Hiltunen, J. Kalervo

“…Mitochondria and fatty acids are tightly connected to a multiplicity of cellular processes that go far beyond mitochondrial fatty acid metabolism. In line with…”
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Odd Chain Fatty Acids; New Insights of the Relationship Between the Gut Microbiota, Dietary Intake, Biosynthesis and Glucose Intolerance by Jenkins, Benjamin J., Seyssel, Kevin, Chiu, Sally, Pan, Pin-Ho, Lin, Shih-Yi, Stanley, Elizabeth, Ament, Zsuzsanna, West, James A., Summerhill, Keith, Griffin, Julian L., Vetter, Walter, Autio, Kaija J., Hiltunen, Kalervo, Hazebrouck, Stéphane, Stepankova, Renata, Chen, Chun-Jung, Alligier, Maud, Laville, Martine, Moore, Mary, Kraft, Guillaume, Cherrington, Alan, King, Sarah, Krauss, Ronald M., de Schryver, Evelyn, Van Veldhoven, Paul P., Ronis, Martin, Koulman, Albert

“…Recent findings have shown an inverse association between circulating C15:0/C17:0 fatty acids with disease risk, therefore, their origin needs to be determined…”
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An engineered variant of MECR reductase reveals indispensability of long-chain acyl-ACPs for mitochondrial respiration by Rahman, M. Tanvir, Koski, M. Kristian, Panecka-Hofman, Joanna, Schmitz, Werner, Kastaniotis, Alexander J., Wade, Rebecca C., Wierenga, Rik K., Hiltunen, J. Kalervo, Autio, Kaija J.

“…Mitochondrial fatty acid synthesis (mtFAS) is essential for respiratory function. MtFAS generates the octanoic acid precursor for lipoic acid synthesis, but…”
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CoA‐dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases by Lambrechts, Roald A, Schepers, Hein, Yu, Yi, van der Zwaag, Marianne, Autio, Kaija J, Vieira‐Lara, Marcel A, Bakker, Barbara M, Tijssen, Marina A, Hayflick, Susan J, Grzeschik, Nicola A, Sibon, Ody CM

“…PKAN, CoPAN, MePAN, and PDH‐E2 deficiency share key phenotypic features but harbor defects in distinct metabolic processes. Selective damage to the globus…”
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Mitochondrial Fatty Acid Synthesis Type II: More than Just Fatty Acids by Hiltunen, J.Kalervo, Schonauer, Melissa S., Autio, Kaija J., Mittelmeier, Telsa M., Kastaniotis, Alexander J., Dieckmann, Carol L.

“…Eukaryotes harbor a highly conserved mitochondrial pathway for fatty acid synthesis (FAS), which is completely independent of the eukaryotic cytosolic FAS…”
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Mitochondrial fatty acid synthesis and respiration by Hiltunen, J. Kalervo, Autio, Kaija J., Schonauer, Melissa S., Kursu, V.A. Samuli, Dieckmann, Carol L., Kastaniotis, Alexander J.

“…Recent studies have revealed that mitochondria are able to synthesize fatty acids in a malonyl-CoA/acyl carrier protein (ACP)-dependent manner. This pathway…”
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Genetic modifications of Mecr reveal a role for mitochondrial 2-enoyl-CoA/ACP reductase in placental development in mice by Nair, Remya R, Kerätär, Juha M, Autio, Kaija J, Masud, Ali J, Finnilä, Mikko A J, Autio-Harmainen, Helena I, Miinalainen, Ilkka J, Nieminen, Pentti A, Hiltunen, J Kalervo, Kastaniotis, Alexander J

“…Mitochondrial fatty acid synthesis (mtFAS) is an underappreciated but highly conserved metabolic process, indispensable for mitochondrial respiration. It was…”
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Role of AMACR (α-methylacyl-CoA racemase) and MFE-1 (peroxisomal multifunctional enzyme-1) in bile acid synthesis in mice by Autio, Kaija J, Schmitz, Werner, Nair, Remya R, Selkälä, Eija M, Sormunen, Raija T, Miinalainen, Ilkka J, Crick, Peter J, Wang, Yuqin, Griffiths, William J, Reddy, Janardan K, Baes, Myriam, Hiltunen, J Kalervo

“…Cholesterol is catabolized to bile acids by peroxisomal β-oxidation in which the side chain of C27-bile acid intermediates is shortened by three carbon atoms…”
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Binding of Brucella protein, Bp26, to select extracellular matrix molecules by ElTahir, Yasmin, Al-Araimi, Amna, Nair, Remya R, Autio, Kaija J, Tu, Hongmin, Leo, Jack C, Al-Marzooqi, Waleed, Johnson, Eugene H

“…Brucella is a facultative intracellular pathogen responsible for zoonotic disease brucellosis. Little is known about the molecular basis of Brucella adherence…”
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Correction to: Binding of Brucella protein, Bp26, to select extracellular matrix molecules by ElTahir, Yasmin, Al-Araimi, Amna, Nair, Remya R, Autio, Kaija J, Tu, Hongmin, Leo, Jack C, Al-Marzooqi, Waleed, Johnson, Eugene H

“…Following publication of the original article [1], an error was reported in the tagging of Eugene H. Johnson and Remya R. Nair in the author group…”
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Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results in severe hypoglycemia with stress intolerance and unimpaired ketogenesis by Miinalainen, Ilkka J, Schmitz, Werner, Huotari, Anne, Autio, Kaija J, Soininen, Raija, Ver Loren van Themaat, Emiel, Baes, Myriam, Herzig, Karl-Heinz, Conzelmann, Ernst, Hiltunen, J Kalervo

“…The mitochondrial beta-oxidation system is one of the central metabolic pathways of energy metabolism in mammals. Enzyme defects in this pathway cause fatty…”
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Exploration of dietary interventions to treat mitochondrial fatty acid disorders in a mouse model by Autio, Kaija J., Koivisto, Hennariikka, Schmitz, Werner, Puronurmi, Anna, Tanila, Heikki, Kastaniotis, Alexander J.

“…•A defect in mitochondrial fatty acid synthesis (mtFAS) leads to neurodegeneration.•MtFAS produces octanoate to serve lipoic acid synthesis.•Dietary octanoic…”
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Htd2p/Yhr067p is a yeast 3‐hydroxyacyl‐ACP dehydratase essential for mitochondrial function and morphology by Kastaniotis, Alexander J., Autio, Kaija J., Sormunen, Raija T., Hiltunen, J. Kalervo

“…Summary Among the recently recognized aspects of mitochondrial functions, in yeast as well as humans, is their ability to synthesize fatty acids in a…”
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Mitochondrial acyl carrier protein (ACP) at the interface of metabolic state sensing and mitochondrial function by Masud, Ali J., Kastaniotis, Alexander J., Rahman, M. Tanvir, Autio, Kaija J., Hiltunen, J. Kalervo

“…Acyl carrier protein (ACP) is a principal partner in the cytosolic and mitochondrial fatty acid synthesis (FAS) pathways. The active form holo-ACP serves as…”
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17B-hydroxysteroid dehydrogenases as acyl thioester metabolizing enzymes by Hiltunen, J. Kalervo, Kastaniotis, Alexander J., Autio, Kaija J., Jiang, Guangyu, Chen, Zhijun, Glumoff, Tuomo

“…17β-Hydroxysteroid dehydrogenases (HSD17B) catalyze the oxidation/reduction of 17β-hydroxy/keto group in position C17 in C18- and C19 steroids. Most HSD17Bs…”
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Mitochondrial Fatty Acids and Neurodegenerative Disorders by Kastaniotis, Alexander J., Autio, Kaija J., R. Nair, Remya

“…Fatty acids in mitochondria, in sensu stricto, arise either as β-oxidation substrates imported via the carnitine shuttle or through de novo synthesis by the…”
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Impaired Mitochondrial Fatty Acid Synthesis Leads to Neurodegeneration in Mice by Nair, Remya R, Koivisto, Henna, Jokivarsi, Kimmo, Miinalainen, Ilkka J, Autio, Kaija J, Manninen, Aki, Poutiainen, Pekka, Tanila, Heikki, Hiltunen, J Kalervo, Kastaniotis, Alexander J

“…There has been a growing interest toward mitochondrial fatty acid synthesis (mtFAS) since the recent discovery of a neurodegenerative human disorder termed…”
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Expression and analysis of the SAM‐dependent RNA methyltransferase Rsm22 from Saccharomyces cerevisiae by Alam, Jahangir, Rahman, Farah Tazkera, Sah-Teli, Shiv K., Venkatesan, Rajaram, Koski, M. Kristian, Autio, Kaija J., Hiltunen, J. Kalervo, Kastaniotis, Alexander J.

“…The Saccharomyces cerevisiae Rsm22 protein (Sc‐Rsm22), encoded by the nuclear RSM22 (systematic name YKL155c) gene, is a distant homologue of Rsm22 from…”
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Mitochondrial 2,4-dienoyl-CoA reductase (Decr) deficiency and impairment of thermogenesis in mouse brown adipose tissue by Mäkelä, Anne M., Hohtola, Esa, Miinalainen, Ilkka J., Autio, Joonas A., Schmitz, Werner, Niemi, Kalle J., Hiltunen, J. Kalervo, Autio, Kaija J.

“…A large number of studies have demonstrated significance of polyunsaturated fatty acids (PUFAs) for human health. However, many aspects on signals translating…”
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Phytol is lethal for Amacr-deficient mice by Selkälä, Eija M., Nair, Remya R., Schmitz, Werner, Kvist, Ari-Pekka, Baes, Myriam, Hiltunen, J. Kalervo, Autio, Kaija J.

“…α-Methylacyl-CoA racemase (Amacr) catalyzes the racemization of the 25-methyl group in C27-intermediates in bile acid synthesis and in methyl-branched fatty…”
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