Search Results - "Auti, Prashant"

Recent advances in the pharmacological diversification of quinazoline/quinazolinone hybrids by Auti, Prashant S, George, Ginson, Paul, Atish T

“…Due to the pharmacological activities of quinazoline and quinazolinone scaffolds, it has aroused great interest in medicinal chemists for the development of…”
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Molecular modelling, synthesis and in vitro evaluation of quinazolinone hybrid analogues as potential pancreatic lipase inhibitors by George, Ginson, Yadav, Nisha, Auti, Prashant S., Paul, Atish Tulshiram

“…Obesity is a multifactorial metabolic disorder, growing in an alarming rate across the world. Amongst the numerous targets explored for obesity management,…”
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Design, synthesis and biological evaluation of N-substituted indole-thiazolidinedione hybrid analogues as potential pancreatic lipase inhibitors by George, Ginson, Auti, Prashant S, Paul, Atish T

“…Pancreatic Lipase (PL) is a key enzyme responsible for the digestion of 50%-70% of dietary triglycerides, hence its inhibition is considered as a viable…”
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Design, Synthesis, Molecular Modelling and in Vitro Evaluation of Indolyl Ketohydrazide‐Hydrazone Analogs as Potential Pancreatic Lipase Inhibitors by Jagetiya, Sakshi, Auti, Prashant S., Paul, Atish T.

“…Inhibition of Pancreatic lipase (PL) is considered to be a promising target for the management of obesity, owing to its crucial role in the digestion of…”
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Synthesis, molecular modelling and pharmacological evaluation of novel indole-thiazolidinedione based hybrid analogues as potential pancreatic lipase inhibitors by George, Ginson, Auti, Prashant S, Sengupta, Pracheta, Yadav, Nisha, Paul, Atish T

“…A series of novel indole-thiazolidinedione hybrid analogues ( to ) were synthesised, characterised and evaluated for their potential Pancreatic Lipase (PL)…”
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Chromone Containing Hybrid Analogs: Synthesis and Applications in Medicinal Chemistry by Auti, Prashant S., Jagetiya, Sakshi, Paul, Atish T.

“…The use of privileged scaffolds has proven beneficial for generating novel bioactive scaffolds in drug discovery program. Chromone is one such privileged…”
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Design, synthesis and biological evaluation of N‐substituted indole‐thiazolidinedione analogues as potential pancreatic lipase inhibitors by George, Ginson, Auti, Prashant S., Paul, Atish T.

“…Pancreatic Lipase (PL) is a key enzyme responsible for the digestion of 50%–70% of dietary triglycerides, hence its inhibition is considered as a viable…”
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Rh(III)-Catalyzed [3 + 2] Annulation via C–H Activation: Direct Access to Trifluoromethyl-Substituted Indenamines and Aminoindanes by Chaudhary, Bharatkumar, Auti, Prashant, Shinde, Suchita Dattatray, Yakkala, Prasanna Anjaneyulu, Giri, Deepesh, Sharma, Satyasheel

“…The rhodium­(III)-catalyzed direct C–H addition and annulation of benzimidates and aldimines with β-(trifluoromethyl)-α,β-unsaturated ketones is described…”
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Discovery of thiazolidinedione-based pancreatic lipase inhibitors as anti-obesity agents: synthesis, in silico studies and pharmacological investigations by Dhiman, Prashant, Yadav, Nisha, Auti, Prashant S, Jaswal, Shalini, Singh, Gurpreet, Mehan, Sidharth, Ghosh, Balaram, Paul, Atish T, Monga, Vikramdeep

“…A series of new 2,5-disubstituted arylidene derivatives of thiazolidinedione ( ) designed using molecular hybridization approach were synthesized, structurally…”
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Systematic literature review of asthma biologic self-administration enhanced by a patient perspective by Boccaletti, Simona, Alfonso-Cristancho, Rafael, Ahmed, Waseem, Sergison, Lehanne, Eze, Adaeze, Auti, Prashant, Alleman, Cathelijne, Badgujar, Lohit, Halfpenny, Nicholas, Heldt, Dorothea

“…Several biologics for the treatment of severe asthma are available as self-administration devices. We performed a systematic literature review to understand…”
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Discovery of novel chromone and acrylate‐based pancreatic lipase inhibitors: Molecular modelling, synthesis, and in vitro evaluation for the treatment of obesity by Auti, Prashant S., Paul, Atish T.

“…By the optimization of previously established pancreatic lipase (PL) inhibitory lead, we have developed novel chromone‐containing analogues with embedded…”
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Chromone-3-acrylic acid ester analogues: Design, synthesis and biological evaluation as potential pancreatic lipase inhibitors by Auti, Prashant S., Jagetiya, Sakshi, Paul, Atish T.

“…•Exploration of chromone heterocycle for pancreatic lipase (PL) inhibition.•Molecular modeling study to check the binding of analogues at active site of…”
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Investigating the role of indole and quinazolinone-based hybrid analogues with ketoamide fragment and alkyl extension for potential PL inhibition by Nandi, Arijit, Auti, Prashant S., Jagtap, Utkarsh A., Paul, Atish T.

“…•Design of hybrid analogues with indolyl oxoacetamide & quinazolinone scaffold synthesis and in vitro PL inhibitory screening of the synthesized…”
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