Search Results - "Austin‐Williams, Shani"

Galectin‐9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin‐dependent manner by Iqbal, Asif J., Krautter, Franziska, Blacksell, Isobel A., Wright, Rachael D., Austin‐Williams, Shani N., Voisin, Mathieu‐Benoit, Hussain, Mohammed T., Law, Hannah L., Niki, Toshiro, Hirashima, Mitsuomi, Bombardieri, Michele, Pitzalis, Costantino, Tiwari, Alok, Nash, Gerard B., Norling, Lucy V., Cooper, Dianne

“…Neutrophil trafficking is a key component of the inflammatory response. Here, we have investigated the role of the immunomodulatory lectin Galectin‐9 (Gal‐9)…”
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The Contrasting Role of Extracellular Vesicles in Vascular Inflammation and Tissue Repair by Oggero, Silvia, Austin-Williams, Shani, Norling, Lucy Victoria

“…Extracellular vesicles are a heterogeneous family of vesicles, generated from different subcellular compartments and released into the extracellular space…”
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Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation by Reglero-Real, Natalia, Pérez-Gutiérrez, Lorena, Yoshimura, Azumi, Rolas, Loïc, Garrido-Mesa, José, Barkaway, Anna, Pickworth, Catherine, Saleeb, Rebeca S., Gonzalez-Nuñez, Maria, Austin-Williams, Shani N., Cooper, Dianne, Vázquez-Martínez, Laura, Fu, Tao, De Rossi, Giulia, Golding, Matthew, Voisin, Mathieu-Benoit, Boulanger, Chantal M., Kubota, Yoshiaki, Muller, William A., Tooze, Sharon A., Nightingale, Thomas D., Collinson, Lucy, Perretti, Mauro, Aksoy, Ezra, Nourshargh, Sussan

“…The migration of neutrophils from the blood circulation to sites of infection or injury is a key immune response and requires the breaching of endothelial…”
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Molecular determinants of neutrophil extracellular vesicles that drive cartilage regeneration in inflammatory arthritis by Thomas, Bethan L, Montero-Melendez, Trinidad, Oggero, Silvia, Kaneva, Magdalena K, Chambers, David, Pinto, Andreia L, Nerviani, Alessandra, Lucchesi, Davide, Austin-Williams, Shani, Hussain, Mohammed T, Pitzalis, Costantino, Allen, Benjamin, Malcangio, Marzia, Dell'Accio, Francesco, Norling, Lucy V, Perretti, Mauro

“…This study was undertaken to establish the potential therapeutic profile of neutrophil-derived extracellular vesicles (EVs) in experimental inflammatory…”
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Mitochondria antioxidant protection against cardiovascular dysfunction programmed by early‐onset gestational hypoxia by Spiroski, Ana‐Mishel, Niu, Youguo, Nicholas, Lisa M., Austin‐Williams, Shani, Camm, Emily J., Sutherland, Megan R., Ashmore, Thomas J., Skeffington, Katie. L., Logan, Angela, Ozanne, Susan E., Murphy, Michael P., Giussani, Dino A.

“…Mitochondria‐derived oxidative stress during fetal development increases cardiovascular risk in adult offspring of pregnancies complicated by chronic fetal…”
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Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling by Bhattacharya, Purbasha, Dhawan, Umesh Kumar, Hussain, Mohammed Tayab, Singh, Praveen, Bhagat, Karran Kiran, Singhal, Aarushi, Austin-Williams, Shani, Sengupta, Shantanu, Subramanian, Manikandan

“…Macrophages release soluble mediators following efferocytic clearance of apoptotic cells to facilitate intercellular communication and promote the resolution…”
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β1-Integrin-Mediated Uptake of Chondrocyte Extracellular Vesicles Regulates Chondrocyte Homeostasis by Hussain, Mohammed Tayab, Austin-Williams, Shani, Wright, Thomas Dudley, Dhawan, Umesh Kumar, Pinto, Andreia L, Cooper, Dianne, Norling, Lucy V

“…Osteoarthritis (OA) is the most prevalent age-related degenerative disorder, which severely reduces the quality of life of those affected. Whilst management…”
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Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac Dysfunction by Chen, Jianmin, Austin-Williams, Shani, O'Riordan, Caroline Elizabeth, Claria-Ribas, Pol, Sugimoto, Michelle A, Norling, Lucy V, Thiemermann, Christoph, Perretti, Mauro

“…Abstract Using a global formyl peptide receptor (Fpr) 2 knockout mouse colony, we have reported the modulatory properties of this pro-resolving receptor in…”
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Enhancing extracellular vesicles for therapeutic treatment of arthritic joints by Austin-Williams, Shani, Hussain, Mohammed T., Oggero, Silvia, Norling, Lucy V.

“…Extracellular vesicles are small membrane-derived packages of information that are released from virtually all cell types. These nano-packages contain…”
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Placental Adaptation to Early-Onset Hypoxic Pregnancy and Mitochondria-Targeted Antioxidant Therapy in a Rodent Model by Nuzzo, Anna M., Camm, Emily J., Sferruzzi-Perri, Amanda N., Ashmore, Thomas J., Yung, Hong-wa, Cindrova-Davies, Tereza, Spiroski, Ana-Mishel, Sutherland, Megan R., Logan, Angela, Austin-Williams, Shani, Burton, Graham J., Rolfo, Alessandro, Todros, Tullia, Murphy, Michael P., Giussani, Dino A.

“…The placenta responds to adverse environmental conditions by adapting its capacity for substrate transfer to maintain fetal growth and development. Early-onset…”
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Aspirin activates resolution pathways to reprogram T cell and macrophage responses in colitis-associated colorectal cancer by De Matteis, Roberta, Flak, Magdalena B, Gonzalez-Nunez, Maria, Austin-Williams, Shani, Palmas, Francesco, Colas, Romain A, Dalli, Jesmond

“…Inflammation is linked with carcinogenesis in many types of cancer including colorectal cancer (CRC). Aspirin is recommended for the prevention of CRC,…”
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PD n-3 DPA Pathway Regulates Human Monocyte Differentiation and Macrophage Function by Pistorius, Kimberly, Souza, Patricia R, De Matteis, Roberta, Austin-Williams, Shani, Primdahl, Karoline G, Vik, Anders, Mazzacuva, Francesca, Colas, Romain A, Marques, Raquel M, Hansen, Trond V, Dalli, Jesmond

“…Macrophages are central in orchestrating the clearance of apoptotic cells and cellular debris during inflammation, with the mechanism(s) regulating this…”
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