Search Results - "Austin, Mark C."

The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder by Jernigan, Courtney S., Goswami, Dharmendra B., Austin, Mark C., Iyo, Abiye H., Chandran, Agata, Stockmeier, Craig A., Karolewicz, Beata

“…Recent studies demonstrate that rapid antidepressant response to ketamine is mediated by activation of the mammalian target of rapamycin (mTOR) signaling…”
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Rational and Translational Implications of D-Amino Acids for Treatment-Resistant Schizophrenia: From Neurobiology to the Clinics by de Bartolomeis, Andrea, Vellucci, Licia, Austin, Mark C., De Simone, Giuseppe, Barone, Annarita

“…Schizophrenia has been conceptualized as a neurodevelopmental disorder with synaptic alterations and aberrant cortical–subcortical connections. Antipsychotics…”
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Mechanistic Role for a Novel Glucocorticoid-KLF11 (TIEG2) Protein Pathway in Stress-induced Monoamine Oxidase A Expression by Grunewald, Matthew, Johnson, Shakevia, Lu, Deyin, Wang, Zhe, Lomberk, Gwen, Albert, Paul R., Stockmeier, Craig A., Meyer, Jeffrey H., Urrutia, Raul, Miczek, Klaus A., Austin, Mark C., Wang, Junming, Paul, Ian A., Woolverton, William L., Seo, Seungmae, Sittman, Donald B., Ou, Xiao-Ming

“…Chronic stress is a risk factor for psychiatric illnesses, including depressive disorders, and is characterized by increased blood glucocorticoids and brain…”
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The Reduction of R1, a Novel Repressor Protein for Monoamine Oxidase A, in Major Depressive Disorder by Johnson, Shakevia, Stockmeier, Craig A, Meyer, Jeffrey H, Austin, Mark C, Albert, Paul R, Wang, Junming, May, Warren L, Rajkowska, Grazyna, Overholser, James C, Jurjus, George, Dieter, Lesa, Johnson, Chandra, Sittman, Donald B, Ou, Xiao-Ming

“…The novel transcriptional repressor protein, R1 (JPO2/CDCA7L/RAM2), inhibits monoamine oxidase A (MAO A) gene expression and influences cell proliferation and…”
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Linking Inflammation, Aberrant Glutamate-Dopamine Interaction, and Post-synaptic Changes: Translational Relevance for Schizophrenia and Antipsychotic Treatment: a Systematic Review by de Bartolomeis, Andrea, Barone, Annarita, Vellucci, Licia, Mazza, Benedetta, Austin, Mark C., Iasevoli, Felice, Ciccarelli, Mariateresa

“…Evidence from clinical, preclinical, and post-mortem studies supports the inflammatory/immune hypothesis of schizophrenia pathogenesis. Less evident is the…”
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17β-Estradiol-Induced Regulation of the Novel 5-HT1A-Related Transcription Factors NUDR and Freud-1 in SH SY5Y Cells by Adeosun, Samuel O., Albert, Paul R., Austin, Mark C., Iyo, Abiye H.

“…Nuclear deformed epidermal autoregulatory factor-1 (NUDR/Deaf-1) and five prime repressor element under dual repression (Freud-1) are novel transcriptional…”
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GABA Transporter-1 mRNA in the Prefrontal Cortex in Schizophrenia: Decreased Expression in a Subset of Neurons by Volk, David W., Austin, Mark C., Pierri, Joseph N., Sampson, Allan R., Lewis, David A.

“…OBJECTIVE: Within the prefrontal cortex of schizophrenic subjects, alterations in markers of -aminobutyric acid (GABA) neurotransmission, including decreased…”
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Reduced phosphorylation of the mTOR signaling pathway components in the amygdala of rats exposed to chronic stress by Chandran, Agata, Iyo, Abiye H., Jernigan, Courtney S., Legutko, Beata, Austin, Mark C., Karolewicz, Beata

“…The activity of the mammalian target of rapamycin (mTOR), an ubiquitously expressed serine/threonine kinase, is central to the regulation of translation…”
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Glial and glutamatergic markers in depression, alcoholism, and their comorbidity by Miguel-Hidalgo, José Javier, Waltzer, Robert, Whittom, Angela A, Austin, Mark C, Rajkowska, Grazyna, Stockmeier, Craig A

“…Abstract Background Alteration of glutamatergic neurotransmission in the prefrontal cortex (PFC) may contribute to the pathophysiology of alcoholism and major…”
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Ethanol Increases TIEG2–MAO B Cell Death Cascade in the Prefrontal Cortex of Ethanol-Preferring Rats by Ou, Xiao-Ming, Johnson, Chandra, Lu, Deyin, Johnson, Shakevia, Paul, Ian A., Austin, Mark C., Iyo, Abiye H., Miguel-Hidalgo, Jose Javier, Luo, Jia, Bell, Richard L., Grunewald, Matthew, Wang, Junming, Sittman, Donald B.

“…Brain cell loss has been reported in subjects with alcoholism. However, the molecular mechanisms are unclear. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)…”
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Key role of the 5-HT1A receptor addressing protein Yif1B in serotonin neurotransmission and SSRI treatment by Martin, Vincent, Mathieu, Lionel, Diaz, Jorge, Salman, Haysam, Alterio, Jeanine, Chevarin, Caroline, Lanfumey, Laurence, Hamon, Michel, Austin, Mark C, Darmon, Michèle, Stockmeier, Craig A, Masson, Justine

“…Altered function of serotonin receptor 1A (5-HT1AR) has been consistently implicated in anxiety, major depressive disorder and resistance to antidepressants…”
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Length of axons expressing the serotonin transporter in orbitofrontal cortex is lower with age in depression by Rajkowska, Grazyna, Mahajan, Gouri, Legutko, Beata, Challagundla, Lavanya, Griswold, Michael, Albert, Paul R., Daigle, Mireille, Miguel-Hidalgo, Jose J., Austin, Mark C., Blakely, Randy D., Steffens, David C., Stockmeier, Craig A.

“…•Axons expressing the serotonin transporter are examined in orbitofrontal cortex from subjects with major depressive disorder.•There was a significant…”
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Gene expression analysis of novel genes in the prefrontal cortex of major depressive disorder subjects by Goswami, Dharmendra B., Jernigan, Courtney S., Chandran, Agata, Iyo, Abiye H., May, Warren L., Austin, Mark C., Stockmeier, Craig A., Karolewicz, Beata

“…Dysregulation of the glutamatergic system has been implicated not only in the treatment of major depressive disorder (MDD), but also in the excitotoxic effects…”
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Transcriptional expression of serotonergic regulators in laser‐captured microdissected dorsal raphe neurons of subjects with major depressive disorder: sex‐specific differences by Goswami, Dharmendra B., May, Warren L., Stockmeier, Craig A., Austin, Mark C.

“…The relationship between serotonin (5‐HT) and major depressive disorder (MDD) has been extensively studied but certain aspects are still ambiguous. Given the…”
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Human Freud-2/CC2D1B: A Novel Repressor of Postsynaptic Serotonin-1A Receptor Expression by Hadjighassem, Mahmoud R, Austin, Mark C, Szewczyk, Bernadeta, Daigle, Mireille, Stockmeier, Craig A, Albert, Paul R

“…Background Altered expression of serotonin-1A (5-HT1A) receptors, both presynaptic in the raphe nuclei and post-synaptic in limbic and cortical target areas,…”
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Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder by Szewczyk, Bernadeta, Albert, Paul R., Burns, Ariel M., Czesak, Margaret, Overholser, James C., Jurjus, George J., Meltzer, Herbert Y., Konick, Lisa C., Dieter, Lesa, Herbst, Nicole, May, Warren, Rajkowska, Grazyna, Stockmeier, Craig A., Austin, Mark C.

“…A variety of studies have documented alterations in 5-HT1A receptor binding sites in the brain of subjects with major depressive disorder (MDD). The recently…”
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A Novel Role for Glyceraldehyde-3-Phosphate Dehydrogenase and Monoamine Oxidase B Cascade in Ethanol-Induced Cellular Damage by Ou, Xiao-Ming, Stockmeier, Craig A, Meltzer, Herbert Y, Overholser, James C, Jurjus, George J, Dieter, Lesa, Chen, Kevin, Lu, Deyin, Johnson, Chandra, Youdim, Moussa B.H, Austin, Mark C, Luo, Jia, Sawa, Akira, May, Warren, Shih, Jean C

“…Background Alcoholism is a major psychiatric condition at least partly associated with ethanol (EtOH)-induced cell damage. Although brain cell loss has been…”
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Increased tryptophan hydroxylase immunoreactivity in the dorsal raphe nucleus of alcohol-dependent, depressed suicide subjects is restricted to the dorsal subnucleus by Bonkale, Willy L., Turecki, Gustavo, Austin, Mark C.

“…Considerable evidence suggests that alcoholics with co‐occurring depressive disorder are at greater risk for developing psychosocial problems particularly…”
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Decreased expression of Freud-1/CC2D1A, a transcriptional repressor of the 5-HT1A receptor, in the prefrontal cortex of subjects with major depression by Szewczyk, Bernadeta, Albert, Paul R., Rogaeva, Anastasia, Fitzgibbon, Heidi, May, Warren L., Rajkowska, Grazyna, Miguel-Hidalgo, Jose J., Stockmeier, Craig A., Woolverton, William L., Kyle, Patrick B., Wang, Zhixia, Austin, Mark C.

“…Serotonin1A (5-HT1A) receptors are reported altered in the brain of subjects with major depressive disorder (MDD). Recent studies have identified…”
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Normal levels of tryptophan hydroxylase immunoreactivity in the dorsal raphe of depressed suicide victims by Bonkale, Willy L., Murdock, Shayna, Janosky, Janine E., Austin, Mark C.

“…A variety of evidence suggests that serotonin neurotransmission is altered in the brain of suicide victims and depressed patients. While numerous post‐mortem…”
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