Search Results - "Austin, Lauren A"

Raman technologies in cancer diagnostics by Austin, Lauren A, Osseiran, Sam, Evans, Conor L

“…Despite significant effort, cancer still remains a leading cause of death worldwide. In order to reduce its burden, the development and improvement of…”
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The optical, photothermal, and facile surface chemical properties of gold and silver nanoparticles in biodiagnostics, therapy, and drug delivery by Austin, Lauren A., Mackey, Megan A., Dreaden, Erik C., El-Sayed, Mostafa A.

“…Nanotechnology is a rapidly growing area of research in part due to its integration into many biomedical applications. Within nanotechnology, gold and silver…”
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Observing Real-Time Molecular Event Dynamics of Apoptosis in Living Cancer Cells using Nuclear-Targeted Plasmonically Enhanced Raman Nanoprobes by Kang, Bin, Austin, Lauren A, El-Sayed, Mostafa A

“…Apoptosis is a biological process that plays important roles in embryogenesis, aging, and various diseases. During the process of apoptosis, cells undergo a…”
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The Most Effective Gold Nanorod Size for Plasmonic Photothermal Therapy: Theory and In Vitro Experiments by Mackey, Megan A, Ali, Moustafa R. K, Austin, Lauren A, Near, Rachel D, El-Sayed, Mostafa A

“…The development of new and improved photothermal contrast agents for the successful treatment of cancer (or other diseases) via plasmonic photothermal therapy…”
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Size matters: gold nanoparticles in targeted cancer drug delivery by Dreaden, Erik C, Austin, Lauren A, Mackey, Megan A, El-Sayed, Mostafa A

“…Cancer is the current leading cause of death worldwide, responsible for approximately one quarter of all deaths in the USA and UK. Nanotechnologies provide…”
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Plasmonic Imaging of Human Oral Cancer Cell Communities during Programmed Cell Death by Nuclear-Targeting Silver Nanoparticles by Austin, Lauren A, Kang, Bin, Yen, Chun-Wan, El-Sayed, Mostafa A

“…Plasmonic nanoparticles (NPs) have become a useful platform in medicine for potential uses in disease diagnosis and treatment. Recently, it has been reported…”
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Real-Time Molecular Imaging throughout the Entire Cell Cycle by Targeted Plasmonic-Enhanced Rayleigh/Raman Spectroscopy by Kang, Bin, Austin, Lauren A, El-Sayed, Mostafa A

“…Due to their strong enhancement of scattered light, plasmonic nanoparticles have been utilized for various biological and medical applications. Here, we…”
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Cytotoxic effects of cytoplasmic-targeted and nuclear-targeted gold and silver nanoparticles in HSC-3 cells – A mechanistic study by Austin, Lauren A., Ahmad, Samera, Kang, Bin, Rommel, Kathryn R., Mahmoud, Mahmoud, Peek, Mary E., El-Sayed, Mostafa A.

“…[Display omitted] •Nuclear-targeted NPs showed increased uptake and cytotoxicity in HSC-3 cells.•Nuclear-targeted AuNP exposure induced a quiescent cellular…”
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Exploiting the Nanoparticle Plasmon Effect: Observing Drug Delivery Dynamics in Single Cells via Raman/Fluorescence Imaging Spectroscopy by Kang, Bin, Afifi, Marwa M, Austin, Lauren A, El-Sayed, Mostafa A

“…Drug delivery systems (DDSs) offer efficient and localized drug transportation as well as reduce associated side effects. In order to better understand DDSs,…”
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A New Nanotechnology Technique for Determining Drug Efficacy Using Targeted Plasmonically Enhanced Single Cell Imaging Spectroscopy by Austin, Lauren A, Kang, Bin, El-Sayed, Mostafa A

“…Recently, we described a new technique, targeted plasmonically enhanced single cell imaging spectroscopy (T-PESCIS), which exploits the plasmonic properties of…”
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Nuclear Targeted Silver Nanospheres Perturb the Cancer Cell Cycle Differently than Those of Nanogold by Austin, Lauren A, Kang, Bin, Yen, Chun-Wan, El-Sayed, Mostafa A

“…Plasmonic nanoparticle research has become increasingly active due to potential uses in biomedical applications. However, little is known about the…”
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Characterization of humoral and cell-mediated immunity induced by mRNA vaccines expressing influenza hemagglutinin stem and nucleoprotein in mice and nonhuman primates by Flynn, Jessica A., Weber, Teresa, Cejas, Pedro J., Cox, Kara S., Touch, Sinoeun, Austin, Lauren A., Ou, Yangsi, Citron, Michael P., Luo, Bin, Gindy, Marian E., Bahl, Kapil, Ciaramella, Giuseppe, Espeseth, Amy S., Zhang, Lan

“…In response to immune pressure, influenza viruses evolve, producing drifted variants capable of escaping immune recognition. One strategy for inducing a…”
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P-Glycoprotein-Dependent Trafficking of Nanoparticle-Drug Conjugates by Dreaden, Erik C., Raji, Idris O., Austin, Lauren A., Fathi, Shaghayegh, Mwakwari, Sandra C., Humphries IV, William H., Kang, Bin, Oyelere, Adegboyega K., El-Sayed, Mostafa A.

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Split-Dose Administration Enhances Immune Responses Elicited by a mRNA/Lipid Nanoparticle Vaccine Expressing Respiratory Syncytial Virus F Protein by Austin, Lauren A., Smith, Jeffrey S., Nahas, Debbie D., Danzinger, Andrew, Secore, Susan, O’Donnell, Gregory, Radcliffe, Scott, Hu, Shuai, Perley, Jeffrey, Bett, Andrew J., Gindy, Marian E.

“…mRNA vaccines have recently received significant attention due to their role in combating the SARS-CoV-2 pandemic. As a platform, mRNA vaccines have been shown…”
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XAV939: From a Small Inhibitor to a Potent Drug Bioconjugate When Delivered by Gold Nanoparticles by Afifi, Marwa M, Austin, Lauren A, Mackey, Megan A, El-Sayed, Mostafa A

“…Nanoparticles as potential drug delivery vectors are drawing more attention every day. Here, we used gold nanopspheres (AuNSs) to selectively target the Wnt…”
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Small Molecule-Gold Nanorod Conjugates Selectively Target and Induce Macrophage Cytotoxicity towards Breast Cancer Cells by Dreaden, Erik C., Mwakwari, Sandra C., Austin, Lauren A., Kieffer, Matthew J., Oyelere, Adegboyega K., El-Sayed, Mostafa A.

“…Gold nanoparticles are known to activate anti‐tumor potential in macrophage immune cells; however, the subsequent effects of these cells on others nearby are…”
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Longitudinal monitoring of cancer cell subpopulations in monolayers, 3D spheroids, and xenografts using the photoconvertible dye DiR by Osseiran, Sam, Austin, Lauren A., Cannon, Taylor M., Yan, Chuan, Langenau, David M., Evans, Conor L.

“…A central challenge in cancer biology is the identification, longitudinal tracking, and -omics analysis of specific cells in vivo . To this aim,…”
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Antiandrogen Gold Nanoparticles Dual-Target and Overcome Treatment Resistance in Hormone-Insensitive Prostate Cancer Cells by Dreaden, Erik C, Gryder, Berkley E, Austin, Lauren A, Tene Defo, Brice A, Hayden, Steven C, Pi, Min, Quarles, L. Darryl, Oyelere, Adegboyega K, El-Sayed, Mostafa A

“…Prostate cancer is the most commonly diagnosed cancer among men in the developed countries. One in six males in the U.S. and one in nine males in the U.K. will…”
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Determining Drug Efficacy Using Plasmonically Enhanced Imaging of the Morphological Changes of Cells upon Death by Aioub, Mena, Austin, Lauren A, El-Sayed, Mostafa A

“…Recently, we utilized the optical properties of gold nanoparticles (AuNPs) for plasmonically enhanced Rayleigh scattering imaging spectroscopy (PERSIS), a new…”
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Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections by Loughran, H. Marie, Schirripa, Kathy M., Roecker, Anthony J., Breslin, Michael J., Tong, Ling, Fillgrove, Kerry L., Kuo, Yuhsin, Bleasby, Kelly, Collier, Hannah, Altman, Michael D., Ford, Melissa C., Newman, Justin A., Drolet, Robert E., Cosden, Mali, Jinn, Sarah, Flick, Rosemarie B., Liu, Xiaomei, Minnick, Christina, Watt, Marla L., Lemaire, Wei, Burlein, Christine, Adam, Gregory C., Austin, Lauren A., Marcus, Jacob N., Smith, Sean M., Fraley, Mark E.

“…Inhibition of glucosylceramide synthase (GCS) has been proposed as a therapeutic strategy for the treatment of Parkinson’s Disease (PD), particularly in…”
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