Search Results - "Austin, J. Christopher"

The translocator protein (TSPO): A novel target for cancer chemotherapy by Austin, Christopher J.D., Kahlert, Jan, Kassiou, Michael, Rendina, Louis M.

“…The translocator protein (TSPO) is an 18kDa transmembrane protein primarily found in the outer mitochondrial membrane where it forms a key part of the…”
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Cecostomy tubes improve bowel continence for pediatric patients with spina bifida: A retrospective analysis of outcomes from a single clinic by Taha, Asma A., Eisen, Aaron M., Abdul Rahman, Hana Q., Good, Kelsey E., Freeman, Kurt A., Kotzin, Jennifer D., Wolf, Margaret H., Azar, Najood G., Davis, Kelley R., Austin, J. Christopher

“…PURPOSE: Pediatric patients with spina bifida often experience neurogenic bowel dysfunction. Although cecostomy tubes could improve bowel continence, their…”
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Abnormal renal scans and decreased early resolution of low grade vesicoureteral reflux by Nepple, Kenneth G, Knudson, Matthew J, Austin, J Christopher, Cooper, Christopher S

“…Limited studies suggest a relationship between scarring on renal scan and failure to resolve vesicoureteral reflux. We evaluated the impact of abnormal renal…”
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The first indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors containing carborane by Austin, Christopher J D, Kahlert, Jan, Issa, Fatiah, Reed, John H, Smith, Jason R, Ioppolo, Joseph A, Ong, Jennifer A, Jamie, Joanne F, Hibbs, David, Rendina, Louis M

“…Indoleamine-2,3-dioxygenase-1 (IDO1) is a critical immunoregulatory enzyme responsible for the metabolism of tryptophan during inflammation and disease. Based…”
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Synchrotron X-ray fluorescence studies of a bromine-labelled cyclic RGD peptide interacting with individual tumor cells by Sheridan, Erin J., Austin, Christopher J. D., Aitken, Jade B., Vogt, Stefan, Jolliffe, Katrina A., Harris, Hugh H., Rendina, Louis M.

“…The first example of synchrotron X‐ray fluorescence imaging of cultured mammalian cells in cyclic peptide research is reported. The study reports the first…”
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Aristotelian essentialism: essence in the age of evolution by Austin, Christopher J.

“…The advent of contemporary evolutionary theory ushered in the eventual decline of the theory of Aristotelian Essentialism (Æ)—for it is widely assumed that…”
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Vesicoureteral Reflux: Who Benefits from Correction by Austin, J. Christopher, MD, Cooper, Christopher S., MD

“…There has been an emergence of a therapeutic nihilistic attitude about the surgical treatment of vesicoureteral reflux (VUR). Evidence-based reviews have…”
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Long-term risks of bladder augmentation in pediatric patients by Austin, J Christopher

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Organisms, activity, and being: on the substance of process ontology by Austin, Christopher J.

“…According to contemporary ‘process ontology’, organisms are best conceptualised as spatio-temporally extended entities whose mereological composition is…”
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DMSA Renal Scans and the Top-Down Approach to Urinary Tract Infection by Austin, J Christopher, Hardy, R Doug, Grose, Charles

“…Assessment of first febrile urinary tract infection in young children has usually involved 2 imaging techniquesrenal ultrasonogram and voiding…”
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Targeting key dioxygenases in tryptophan–kynurenine metabolism for immunomodulation and cancer chemotherapy by Austin, Christopher J.D., Rendina, Louis M.

“…•The mechanisms by which TDO/IDO1/IDO2 exert their immunosuppressive effects in cancer.•Active site topological features important to drug design for each…”
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Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenases IDOs from monotremes and marsupials by Yuasa, Hajime J, Ball, Helen J, Ho, Yuen Fern, Austin, Christopher J D, Whittington, Camilla M, Belov, Katherine, Maghzal, Ghassan J, Jermiin, Lars S, Hunt, Nicholas H

“…Indoleamine 2,3-dioxygenase (IDO1) and tryptophan 2,3-dioxygenase (TDO) are tryptophan-degrading enzymes that catalyze the first step in tryptophan catabolism…”
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Local thermal adaptation detected during multiple life stages across populations of Drosophila melanogaster by Austin, Christopher J., Moehring, Amanda J.

“…Thermal adaptation is typically detected by examining the tolerance of a few populations to extreme temperatures within a single life stage. However, the…”
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The ontology of organisms: Mechanistic modules or patterned processes? by Austin, Christopher J.

“…Though the realm of biology has long been under the philosophical rule of the mechanistic magisterium, recent years have seen a surprisingly steady rise in the…”
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Validation of a prognostic calculator for prediction of early vesicoureteral reflux resolution in children by Shiraishi, Koji, Matsuyama, Hideyasu, Nepple, Kenneth G, Wald, Moshe, Niederberger, Craig S, Austin, Christopher J, Cooper, Christopher S

“…Treatment of vesicoureteral reflux with observation or surgery is based on a number of clinical variables. We developed a prognostic calculator to predict…”
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Design and Methodological Considerations of the Centers for Disease Control and Prevention Urologic and Renal Protocol for the Newborn and Young Child with Spina Bifida by Routh, Jonathan C, Cheng, Earl Y, Austin, J. Christopher, Baum, Michelle A, Gargollo, Patricio C, Grady, Richard W, Herron, Adrienne R, Kim, Steven S, King, Shelly J, Koh, Chester J, Paramsothy, Pangaja, Raman, Lisa, Schechter, Michael S, Smith, Kathryn A, Tanaka, Stacy T, Thibadeau, Judy K, Walker, William O, Wallis, M. Chad, Wiener, John S, Joseph, David B

“…Purpose Care of children with spina bifida has significantly advanced in the last half century, resulting in gains in longevity and quality of life for…”
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A male murine model of partial bladder outlet obstruction reveals changes in detrusor morphology, contractility and Myosin isoform expression by Austin, J Christopher, Chacko, Samuel K, DiSanto, Michael, Canning, Douglas A, Zderic, Stephen A

“…Mice with gene deletion or targeted over expression are important for understanding the remodeling that follows partial bladder outlet obstruction (PBOO). This…”
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Evo-devo: a science of dispositions by Austin, Christopher J.

“…Evolutionary developmental biology (evo-devo) represents a paradigm shift in the understanding of the ontogenesis and evolutionary progression of the denizens…”
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Ultrasound-assisted repair of a unique case of distal vaginal agenesis by Kresowik, Jessica, B.A, Ryan, Ginny L., M.D, Austin, J. Christopher, M.D, Van Voorhis, Bradley J., M.D

“…Objective To describe a unique vaginal outlet obstruction and its ultrasound-assisted surgical correction. Design Case report. Setting An academic medical…”
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Relative value units do not adequately account for operative time in pediatric urology by Jiang, Da David, Chakiryan, Nicholas H, Gillis, Kyle A, Acevedo, Ann Martinez, Chen, Yiyi, Austin, J Christopher, Seideman, Casey A

“…Relative value units (RVUs) are the measure of value used in United States Medicare and Medicaid reimbursement. The Relative Update Committee (RUC) determines…”
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