Search Results - "Austen, Belinda"

Mutation Status of the Residual ATM Allele Is an Important Determinant of the Cellular Response to Chemotherapy and Survival in Patients With Chronic Lymphocytic Leukemia Containing an 11q Deletion by Austen, Belinda, Skowronska, Anna, Baker, Claire, Powell, Judith E, Gardiner, Anne, Oscier, David, Majid, Aneela, Dyer, Martin, Siebert, Reiner, Taylor, A Malcolm, Moss, Paul A, Stankovic, Tatjana

“…The ataxia telangiectasia mutated (ATM) gene is located on chromosome 11q and loss of this region is common in B-cell chronic lymphocytic leukemia (CLL). Our…”
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ATM germline heterozygosity does not play a role in chronic lymphocytic leukemia initiation but influences rapid disease progression through loss of the remaining ATM allele by SKOWRONSKA, Anna, AUSTEN, Belinda, TAYLOR, Malcolm A, STANKOVIC, Tatjana, POWELL, Judith E, WESTON, Victoria, OSCIER, David G, DYER, Martin J. S, MATUTES, Estella, PRATT, Guy, FEGAN, Christopher, MOSS, Paul

“…Ataxia telangiectasia patients, with constitutional bi-allelic ATM mutations, have a marked risk of lymphoid tumors and ATM mutation carriers have a smaller…”
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Intestinal perforation secondary to haematopoietic stem cell transplant associated thrombotic microangiopathy by Hewamana, Saman, Austen, Belinda, Murray, James, Johnson, Sarah, Wilson, Keith

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Frequent epigenetic inactivation of the SLIT2 gene in chronic and acute lymphocytic leukemia by Dunwell, Thomas L., Dickinson, Rachel E., Stankovic, Tatjana, Dallol, Ashraf, Weston, Victoria, Austen, Belinda, Catchpoole, Daniel, Maher, Eamonn R., Latif, Farida

“…Recently a mouse model of T/natural killer acute lymphoblastic leukemia was used to assess global promoter methylation across the mouse genome using the…”
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Calreticulin mutations and their importance in splanchnic vein thrombosis by Sekhar, Mallika, Patch, David, Austen, Belinda, Howard, Joanne, Hart, Stephen

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Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers by Pepper, Chris, Lin, Thet Thet, Pratt, Guy, Hewamana, Saman, Brennan, Paul, Hiller, Louise, Hills, Robert, Ward, Rachel, Starczynski, Jane, Austen, Belinda, Hooper, Laura, Stankovic, Tatjana, Fegan, Chris

“…Bcl-2 family proteins play a critical role in the regulation of apoptosis in chronic lymphocytic leukemia (CLL). However, their association with established…”
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Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL by Austen, Belinda, Powell, Judith E., Alvi, Azra, Edwards, Ian, Hooper, Laura, Starczynski, Jane, Taylor, A. Malcolm R., Fegan, Christopher, Moss, Paul, Stankovic, Tatjana

“…The ataxia telangiectasia mutated (ATM) protein is the principal activator of the p53 protein in the response to DNA double-strand breaks. Mutations in the ATM…”
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The Target UK Study: Real-World Evidence of Molecular Response to Tyrosine Kinase Inhibitors Supports European Leukemianet 2013 Recommendations for the Management of Chronic Myeloid Leukaemia by Milojkovic, Dragana, Clark, Richard E., Byrne, Jennifer L, Huntly, Brian J.P, Raghavan, Manoj, Wandroo, Farooq A, Ali, Sahra, Austen, Belinda, Ryan, Jacqueline, Friedrich, Karsten, Cross, Nicholas C.P., Mead, Adam J

“…Introduction: Several recent studies have shown the speed and depth of response to tyrosine kinase inhibitor (TKI) treatment to be an important indicator of…”
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A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival by Alvi, Azra J., Austen, Belinda, Weston, Victoria J., Fegan, Christopher, MacCallum, David, Gianella-Borradori, Athos, Lane, David P., Hubank, Mike, Powell, Judith E., Wei, Wenbin, Taylor, A. Malcolm R., Moss, Paul A.H., Stankovic, Tatjana

“…B-cell chronic lymphocytic leukemia (B-CLL) is a clinically variable disease where mutations in DNA damage response genes ATM or TP53 affect the response to…”
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South Asian chronic lymphocytic leukaemia patients have more rapid disease progression in comparison to White patients by Gunawardana, Chaminda, Austen, Belinda, Powell, Judith E., Fegan, Christopher, Wandroo, Farooq, Jacobs, Abe, Pratt, Guy, Moss, Paul

“…Summary Ethnicity has a major impact on the prevalence of chronic lymphocytic leukaemia (CLL) and may also influence disease phenotype. We compared the…”
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Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses by Stankovic, Tatjana, Hubank, Mike, Cronin, Debbie, Stewart, Grant S., Fletcher, Danielle, Bignell, Colin R., Alvi, Azra J., Austen, Belinda, Weston, Victoria J., Fegan, Christopher, Byrd, Philip J., Moss, PaulA.H., Taylor, A. Malcolm R.

“…The ATM/p53-dependent DNA damage response pathway plays an important role in the progression of lymphoid tumors. Inactivation of the ATM or TP53 gene is…”
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Increased Frequency of Constitutional PathogenicATM Mutations in CLL Patients Compared to Control Individuals Suggests An Aetiological Role by Stankovic, Tatjana, Austen, Belinda, Pratt, Guy, Skowronska, Anna, Oscier, David, Dyer, Martin JS, Matutes, Estella, Taylor, Malcolm, Moss, Paul

“…Abstract 1250 Poster Board I-272 The genetic cause of the inherited predisposition for the development of CLL is largely unknown. Genome wide association…”
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Pathogenic ATM mutations occur rarely in a subset of multiple myeloma patients by Austen, Belinda, Barone, Giancarlo, Reiman, Anne, Byrd, Philip J., Baker, Claire, Starczynski, Jane, Nobbs, Michael C., Murphy, Raymond P., Enright, Helen, Chaila, Elijah, Quinn, John, Stankovic, Tatjana, Pratt, Guy, Taylor, A. Malcolm R.

“…Summary Ataxia Telangiectasia (A‐T) patients have biallelic inactivation of the ATM gene and exhibit a 200‐fold‐increased frequency of lymphoid tumours. ATM…”
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Apoptotic resistance to ionizing radiation in pediatric B-precursor acute lymphoblastic leukemia frequently involves increased NF-κB survival pathway signaling by Weston, Victoria J., Austen, Belinda, Wei, Wenbin, Marston, Eliot, Alvi, Azra, Lawson, Sarah, Darbyshire, Philip J., Griffiths, Mike, Hill, Frank, Mann, Jill R., Moss, Paul A.H., Taylor, A. Malcolm R., Stankovic, Tatjana

“…To investigate possible causes of the variable response to treatment in pediatric B-precursor acute lymphoblastic leukemia (ALL) and to establish potential…”
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Chronic Lymphocytic Leukaemia Has a More Aggressive Phenotype in Asians Compared to Caucasians by Austen, Belinda, Gunawardana, Chaminda, Pratt, Guy, Wandroo, Farooq, Jacobs, Abe, Powell, Judith, Moss, Paul

“…Chronic lymphocytic leukaemia (CLL) is the commonest leukaemia in the western world with an incidence of 3 per 100,000. The precise aetiology remains obscure…”
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The Novel PARP Inhibitor, AZD2281, Targets Apoptotic Resistant ATM Mutant CLL Tumours for Cellular Killing by Weston, Victoria, Baker, Claire, Austen, Belinda, Taylor, Malcolm, Moss, Paul, Stankovic, Tanja

“…B-CLL is incurable and the development of resistance to standard chemotherapeutics remains an important problem. ATM mutations lead to chemo-resistance in a…”
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ATM Mutations Define a Subset of B-CLL Tumours That Only Partially Correlates with 11q Status and Is Associated with Impaired Patient Survival by Austen, Belinda, Fegan, Christopher, Moss, Paul, Stankovic, Tanja

“…The clinical progression of B cell chronic lymphocytic leukaemia (B-CLL) is heterogeneous and prognostic markers are important both for patient management and…”
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Stratification by DNA Damage-Induced Apoptotic and Transcriptional Responses Provides Insight into the Molecular Mechanisms Underlying Blast Clearance Rates in Paediatric B-Precursor ALL by Marston, Eliot, Weston, Victoria, Austen, Belinda, Wakelam, Michael, Lawson, Sarah, Darbyshire, Phil, Jesson, Jenny, Moss, Paul, Stankovic, Tatjana

“…Although there have been dramatic improvements in the treatment of paediatric ALL in recent years, a significant proportion of these patients still experience…”
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A Novel Functional Assay Using Etoposide Plus Nutlin 3, FISH and Mutational Analysis Detects Heterogeneity of ATM/p53 Pathway Alterations in CLL by Best, Giles, Gardiner, Anne, Ibbotson, Rachel, Majid, Aneela, Walewska, Renata, Austen, Belinda, Stankovic, Tanja, Dyer, Martin, Oscier, David Graham

“…Abnormalities of the ATM and p53 genes can be detected by interphase FISH, mutational analysis or functional assays. The latter measure up-regulation of p53 or…”
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CLL Tumours with a Deletion of 11q Form Two Functional Subgroups Based on the Mutation Status of the Remaining ATM Allele by Austen, Belinda, Podinovskaia, Maria, Almond, Claire, Fews, Graham, Gardiner, Anne, Oscier, David, Moss, Paul, Stankovic, Tanja

“…Deletions in chromosome 11q are an established prognostic marker in CLL. One copy of the ATM gene is deleted in these tumours, as detected by FISH analysis…”
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