Search Results - "Aust, A E"

Participation of iron and nitric oxide in the mutagenicity of asbestos in hgprt-, gpt+ Chinese hamster V79 cells by PARK, S.-H, AUST, A. E

“…Crocidolite asbestos is known to cause cellular damage, leading to asbestosis, bronchogenic carcinoma, and mesothelioma in humans. The mechanism responsible…”
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Efflux of Reduced Glutathione after Exposure of Human Lung Epithelial Cells to Crocidolite Asbestos by Golladay, Scott A., Park, Sun-Hee, Aust, Ann E.

“…This study investigated glutathione (GSH) homeostasis in human lung epithelial cells (A549) exposed to crocidolite. Exposure of A549 cells to 3 μ g/…”
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The effect of iron binding on the ability of crocidolite asbestos to catalyze DNA single-strand breaks by Hardy, J A, Aust, A E

“…Crocidolite or crocidolite pretreated with desferrioxamine-B (DF crocidolite) was exposed to ferrous chloride solutions to determine whether iron could be…”
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Iron-catalyzed reactions may be responsible for the biochemical and biological effects of asbestos by Lund, L G, Aust, A E

“…The most carcinogenic forms of asbestos contain iron to levels as high as 36% by weight and catalyze many of the same biochemical reactions that freshly…”
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Iron associated with asbestos bodies is responsible for the formation of single strand breaks in phi X174 RFI DNA by Lund, L G, Williams, M G, Dodson, R F, Aust, A E

“…The ability of amosite cored asbestos bodies isolated from human lungs to catalyse damage to phi X174 RFI DNA in vitro was measured and compared with that of…”
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Bioavailability of iron from coal fly ash: mechanisms of mobilization and of biological effects by Ball, B R, Smith, K R, Veranth, J M, Aust, A E

“…Particulate air pollution contains iron that may be involved in the pathological effects after inhalation. This article reviews work demonstrating that ambient…”
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Iron mobilization from asbestos by chelators and ascorbic acid by Lund, L G, Aust, A E

“…The ability of chelators and ascorbic acid to mobilize iron from crocidolite, amosite, medium- and short-fiber chrysotile, and tremolite was investigated…”
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Using in Vitro Iron Deposition on Asbestos To Model Asbestos Bodies Formed in Human Lung by Shen, Zhihua, Bosbach, Dirk, Hochella, Michael F, Bish, David L, Williams, M. Glenn, Dodson, Ronald F, Aust, Ann E

“…Recent studies have shown that iron is an important factor in the chemical activity of asbestos and may play a key role in its biological effects. The most…”
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Effect of long-term removal of iron from asbestos by desferrioxamine B on subsequent mobilization by other chelators and induction of DNA single-strand breaks by Chao, C C, Aust, A E

“…The long-term removal of iron from crocidolite or amosite by desferrioxamine B (DF) at pH 7.5 or 5.0 was studied. Crocidolite or amosite (1 mg/ml) was…”
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Role of Iron in the Cellular Effects of Asbestos by Aust, E. Ann, Lund, Loren G., Chao, Chien-Chung, Park, Sun-Hee, Fang, Ruihua

“…Research to understand how the physical characteristics of asbestos fibers impact the pathological effects has intensified in the past 10 years. The role that…”
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Mobilization of iron from crocidolite asbestos by certain chelators results in enhanced crocidolite-dependent oxygen consumption by Lund, L G, Aust, A E

“…The reactivity of iron on crocidolite asbestos with dioxygen was determined and compared with iron mobilized from crocidolite. Ferrozine, a strong Fe(II)…”
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Mobilization of Iron from Urban Particulates Leads to Generation of Reactive Oxygen Species in Vitro and Induction of Ferritin Synthesis in Human Lung Epithelial Cells by Smith, Kevin R, Aust, Ann E

“…Many of the biochemical effects of asbestos in cultured cells have been shown to be due to iron, which can be as high as 27% by weight. Urban air particulates…”
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Photochemical reduction of ferric iron by chelators results in DNA strand breaks by Chao, C C, Aust, A E

“…The induction of single-strand breaks (SSB) in phi X174 RFI DNA by Fe(III) chelates under cool-white fluorescent (CWF) light or in darkness was investigated…”
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Interleukin-8 Levels in Human Lung Epithelial Cells Are Increased in Response to Coal Fly Ash and Vary with the Bioavailability of Iron, as a Function of Particle Size and Source of Coal by Smith, Kevin R, Veranth, John M, Hu, Autumn A, Lighty, JoAnn S, Aust, Ann E

“…Particulate air pollution contains iron, and some of the pathological effects after inhalation may be due to radical species produced by iron-catalyzed…”
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IN VITRO EFFECTS OF COAL FLY ASHES: Hydroxyl Radical Generation, Iron Release, and DNA Damage and Toxicity in Rat Lung Epithelial Cells by van Maanen, J M, Borm, P J, Knaapen, A, van Herwijnen, M, Schilderman, P A, Smith, K R, Aust, A E, Tomatis, M, Fubini, B

“…Oxygen radical generation due to surface radicals, inflammation, and iron release has been suggested as the mechanism of adverse effects of quartz, such as…”
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Iron mobilization from crocidolite asbestos greatly enhances crocidolite-dependent formation of DNA single-strand breaks in phi X174 RFI DNA by Lund, L G, Aust, A E

“…The ability of the iron associated with asbestos to catalyze damage to phi X174 RFI DNA was determined and compared with iron mobilized from asbestos. Asbestos…”
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The Formation of Reactive Oxygen Species Catalyzed by Neutral, Aqueous Extracts of NIST Ambient Particulate Matter and Diesel Engine Particles by Ball, James C., Straccia, Ann M., Young, Willie C., Aust, Ann E.

“…It is important to characterize the chemical properties of particulate matter in order to understand how low doses, inhaled by a susceptible population, might…”
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Induction of Ferritin Synthesis in Human Lung Epithelial Cells Treated with Crocidolite Asbestos by Fang, Ruihua, Aust, Ann E.

“…Crocidolite asbestos is a known human carcinogen containing 27% iron by weight. It has previously been shown that iron was mobilized intracellularly from…”
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Participation of Nitric Oxide and Iron in the Oxidation of DNA in Asbestos-Treated Human Lung Epithelial Cells by Chao, Chien-Chung, Park, Sun-Hee, Aust, Ann E.

“…Treatment of human lung epithelial (A549) cells with crocidolite resulted in the formation of 8-hydroxy-2′-deoxyguanosine (8-OHdG) in the DNA, synthesis of…”
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Mössbauer Spectroscopy Indicates That Iron in an Aluminosilicate Glass Phase Is the Source of the Bioavailable Iron from Coal Fly Ash by Veranth, John M, Smith, Kevin R, Huggins, Frank, Hu, Autumn A, Lighty, JoAnn S, Aust, Ann E

“…Iron speciation by Mössbauer spectroscopy indicates that ferric iron in an aluminosilicate glass phase is the source of the bioavailable iron in coal fly ash…”
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